 | | Vol. 6.25 – 19 July, 2021 |
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| Researchers reported that inactivation of the mechanosensitive transcription factor Foxc2 in adult lymphatic endothelium led to a stepwise intestine-to-lung systemic failure.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated whether a gridded 3D bioprinted construct would allow ingrowth of blood vessels and thus proved a functional concept for vascularization of bioengineered tissue.
[Biomaterials] |
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| Endothelial deletion of TGF-β receptor I (Alk5) inhibited D-tip cell identity acquisition and deep vascular plexus formation. Loss of endothelial ALK5, but not of the canonical SMAD effectors, led to aberrant contractile pericyte differentiation and hemorrhagic vascular malformations.
[Developmental Cell] |
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| GPR35 is a poorly characterized receptor that has garnered increased interest as a therapeutic target through its implications in a range of inflammatory and cardiovascular diseases. Scientists evaluated the effect of GPR35 on endothelial cell functions and hemodynamic homeostasis.
[Hypertension] |
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| In vitro experiments revealed that perfluorohexane @polylactic acid-glycolic acid/ manganese ferrite 4-ramucirumab nanoparticles (NPs) actively accumulated in rabbit aortic endothelial cells, and NP-mediated photothermal therapy promoted endothelial cell apoptosis while inhibiting their proliferation, migration, and tubulogenesis.
[Biomaterials Science] |
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| Researchers investigated the role of FOXA1 in the interactions between prostate cancer cells and endothelial cells.
[Journal of Cancer Research and Clinical Oncology] |
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| The authors provided a detailed proteomic comparison between functional and dysfunctional endothelial colony‐forming cells.
[Journal of the American Heart Association] |
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| Single-cell RNA sequencing technology was used to decipher the cellular heterogeneity among pulmonary arterial endothelial cells in the human pulmonary arteries isolated from explanted lungs from three patients with pulmonary arterial hypertension undergoing lung transplantation and three healthy donor lungs not utilized for transplantation.
[Scientific Reports] |
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| Researchers proposed a novel method to create three-layered tissue engineered vascular grafts on biocompatible glass fiber scaffolds starting from flat sheet state into tubular shape and to train the resulting tissue using their developed bioreactor system.
[Scientific Reports] |
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| Scientists showed that TNF-α significantly reduced the expression of sirtuin 6 (SIRT6) protein and mRNA in a concentration- and time-dependent manner and increased the expression of monocyte chemotactic protein 1, interleukin (IL) -6 and IL-1β in HUVECs.
[International Immunopharmacology] |
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| The authors proposed a meshless-based model capable of mimicking the angiogenic response to several VEGF concentrations.
[Computers in Biology and Medicine] |
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| Using a tube formation assay between HTR8/SVneo cells and HUVECs, scientists found that T cell immunoglobulin mucin-3 (Tim-3) pathway blockade inhibited tube formation and reversed by addition of recombinant IL-4 and/or IL-10.
[Reproductive Sciences] |
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| The authors delineate the role of the endothelium in severe complications after allogeneic hematopoietic stem cell transplantation and describe the current status of search for biomarkers predicting endothelial complications, including markers of endothelial vulnerability and markers of endothelial injury.
[Bone Marrow Transplantation] |
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| Arch Biopartners, Inc. announced that the Government of Canada has awarded a contribution of up to $6.7 million to support the Phase II development of Metablok, the company’s therapeutic drug candidate to prevent organ inflammation and injury in patients hospitalized with COVID-19.
[Arch Biopartners, Inc. (Globe Newswire, Inc.)] |
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| September 1 – 3, 2021
Virtual |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Stanford University – Palo Alto, California, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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