| Vol. 6.26 – 26 July, 2021 |
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| S-nitrosylation of guanine nucleotide-binding protein G(i) subunit alpha-2 acted by coupling with CXCR5 to dephosphorylate the Hippo pathway kinase LATS1, thereby leading to nuclear translocation of YAP and promoting an inflammatory response in endothelial cells. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported that 3-hydroxy-L-kynurenamine was a biogenic amine produced via an alternative pathway of tryptophan metabolism. [Nature Communications] |
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| Scientists immortalized HUVECs and fibroblasts (FBs) by exogenously expressing human telomerase reverse transcriptase to obtain stable endothelial cell and FB sources for microvascular networks formation in vitro. [Biomaterials] |
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| Nineteen extracellular vesicle surface antigens were differentially expressed in patients with primary aldosteronism compared with patients with essential hypertension or normotensive controls, including markers of activated platelets, endothelial and immune/inflammatory cells. [Hypertension] |
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| Scientists showed that heme oxygenase-1 (HO-1) was accumulated in the nuclei of stress-induced senescent endothelial cells, and conferred protection against endothelial senescence independent of its enzymatic activity. [Cell Death & Disease] |
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| Scientists found that L-SIGN was highly expressed on human liver sinusoidal endothelial cells and lymph node lymphatic endothelial cells but not on blood endothelial cells. [JCI Insight] |
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| FAM149A was found to be highly expressed in corneal endothelium, and up-regulated upon oxidative stress. [Free Radical Biology and Medicine] |
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| Primary podocytes were isolated and subjected to analysis of Wnt signaling and fatty acid metabolism. Conditioned media from primary podocytes was transferred to glomerular endothelial cells. [Journal of the American Heart Association] |
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| Researchers characterized primary coagulation factor VIII (FVIII)-producing organ and cell species using genetically engineered mice, in which enhanced green fluorescent protein was expressed instead of the F8 gene. [Scientific Reports] |
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| The angiogenesis of the films was tested in human umbilical vein endothelial cells by cell migration, tube formation, and VEGF quantification in vitro, and by a chicken embryo chorioallantoic membrane assay in vivo. [Biomedical Microdevices] |
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| The authors summarize the biogenesis, characteristics and functions of circular RNAs with a focus on their roles in the pathogenesis of atherosclerosis. [Vascular Pharmacology] |
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| The authors provide an overview of the features, process, function, and mechanisms of ferroptosis, and its increasingly connected relevance to oxidative stress, inflammation, and cardiovascular diseases. [Cell Death Discovery] |
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| Merck announced that the European Commission has granted marketing authorization in the European Union for soluble guanylate cyclase stimulator VERQUVO®, indicated for the treatment of symptomatic chronic heart failure in adult patients with reduced ejection fraction. [Merck] |
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| February 14 – 17, 2022 Puerto Vallarta, Mexico |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| Albert Einstein College of Medicine – New York, New York, United States |
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| Stanford University – Palo Alto, California, United States |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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