Endothelial Cell News Volume 6.26 | Jul 26 2021

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    2021-07-26 | ENDOCN 6.26


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.26 – 26 July, 2021
    TOP STORY

    S-Nitrosylation-Mediated Coupling of G-Protein Alpha-2 with CXCR5 Induces Hippo/YAP-Dependent Diabetes-Accelerated Atherosclerosis

    S-nitrosylation of guanine nucleotide-binding protein G(i) subunit alpha-2 acted by coupling with CXCR5 to dephosphorylate the Hippo pathway kinase LATS1, thereby leading to nuclear translocation of YAP and promoting an inflammatory response in endothelial cells.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    3-Hydroxy-L-Kynurenamine Is an Immunomodulatory Biogenic Amine

    The authors reported that 3-hydroxy-L-kynurenamine was a biogenic amine produced via an alternative pathway of tryptophan metabolism.
    [Nature Communications]

    Full Article

    A Robust Vasculogenic Microfluidic Model Using Human Immortalized Endothelial Cells and Thy1 Positive Fibroblasts

    Scientists immortalized HUVECs and fibroblasts (FBs) by exogenously expressing human telomerase reverse transcriptase to obtain stable endothelial cell and FB sources for microvascular networks formation in vitro.
    [Biomaterials]

    Abstract

    Characterization of Circulating Extracellular Vesicle Surface Antigens in Patients with Primary Aldosteronism

    Nineteen extracellular vesicle surface antigens were differentially expressed in patients with primary aldosteronism compared with patients with essential hypertension or normotensive controls, including markers of activated platelets, endothelial and immune/inflammatory cells.
    [Hypertension]

    Abstract

    HO-1 Nuclear Accumulation and Interaction with NPM1 Protect against Stress-Induced Endothelial Senescence Independent of Its Enzymatic Activity

    Scientists showed that heme oxygenase-1 (HO-1) was accumulated in the nuclei of stress-induced senescent endothelial cells, and conferred protection against endothelial senescence independent of its enzymatic activity.
    [Cell Death & Disease]

    Full Article

    L-SIGN Is a Receptor on Liver Sinusoidal Endothelial Cells for SARS-CoV-2 Virus

    Scientists found that L-SIGN was highly expressed on human liver sinusoidal endothelial cells and lymph node lymphatic endothelial cells but not on blood endothelial cells.
    [JCI Insight]

    Full ArticleGraphical Abstract

    Whole Exome Sequencing Identified FAM149A as a Plausible Causative Gene for Congenital Hereditary Endothelial Dystrophy, Affecting Nrf2-Antioxidant Signaling upon Oxidative Stress

    FAM149A was found to be highly expressed in corneal endothelium, and up-regulated upon oxidative stress.
    [Free Radical Biology and Medicine]

    AbstractGraphical Abstract

    Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus

    Primary podocytes were isolated and subjected to analysis of Wnt signaling and fatty acid metabolism. Conditioned media from primary podocytes was transferred to glomerular endothelial cells.
    [Journal of the American Heart Association]

    Full Article

    Characterization and Visualization of Murine Coagulation Factor VIII-Producing Cells In Vivo

    Researchers characterized primary coagulation factor VIII (FVIII)-producing organ and cell species using genetically engineered mice, in which enhanced green fluorescent protein was expressed instead of the F8 gene.
    [Scientific Reports]

    Full Article

    Copper Coating Formed by Micro-Arc Oxidation on Pure Mg Improved Antibacterial Activity, Osteogenesis, and Angiogenesis In Vivo and In Vitro

    The angiogenesis of the films was tested in human umbilical vein endothelial cells by cell migration, tube formation, and VEGF quantification in vitro, and by a chicken embryo chorioallantoic membrane assay in vivo.
    [Biomedical Microdevices]

    Abstract

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    REVIEWS

    Exploring the Regulatory Roles of Circular RNAs in the Pathogenesis of Atherosclerosis

    The authors summarize the biogenesis, characteristics and functions of circular RNAs with a focus on their roles in the pathogenesis of atherosclerosis.
    [Vascular Pharmacology]

    Abstract

    Ferroptosis: A Cell Death Connecting Oxidative Stress, Inflammation and Cardiovascular Diseases

    The authors provide an overview of the features, process, function, and mechanisms of ferroptosis, and its increasingly connected relevance to oxidative stress, inflammation, and cardiovascular diseases.
    [Cell Death Discovery]

    Full Article

    INDUSTRY AND POLICY NEWS

    VERQUVO® (Vericiguat) Approved in the European Union

    Merck announced that the European Commission has granted marketing authorization in the European Union for soluble guanylate cyclase stimulator VERQUVO®, indicated for the treatment of symptomatic chronic heart failure in adult patients with reduced ejection fraction.
    [Merck]

    Full Article

    FEATURED EVENT

    2nd Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference

    February 14 – 17, 2022
    Puerto Vallarta, Mexico

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    JOB OPPORTUNITIES

    Research Assistant II – Lung Cancers

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Researcher – Stem Cells, Organoids, and Systems Biology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Fellow – Retinal Differentiation

    Albert Einstein College of Medicine – New York, New York, United States

    Assistant, Associate, or Full Professor – Stem Cell Biology and Regenerative/Restorative Medicine

    Stanford University – Palo Alto, California, United States

    Postdoctoral Fellow – Modeling of Cardiac Disease

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    > See All Jobs

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