Endothelial Cell News Volume 6.30 | Aug 30 2021

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    Justin.choi
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    2021-08-30 | ENDOCN 6.30


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.30 – 30 August, 2021
    TOP STORY

    Selective Thrombosis of Tumor for Enhanced Hypoxia-Activated Prodrug Therapy

    By encapsulating coagulation-inducing protease thrombin and a hypoxia-activated prodrug tirapazamine into metal–organic framework nanoparticles with a tumor-homing ligand, the obtained nanoplatform selectively activated platelet aggregation at the tumor to induce thrombosis and vascular obstruction therapy by the exposed thrombin.
    [Advanced Materials]

    Abstract
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    Fetal Hematopoietic Stem Cell Homing Is Controlled by VEGF Regulating the Integrity and Oxidative Status of the Stromal-Vascular Bone Marrow Niches

    By studying physiological homing of fetal hematopoietic stem and progenitor cells (HSPCs), scientists showed the critical requirement of balanced local crosstalk within the skeletal niche for successful HSPC settlement in bone marrow.
    [Cell Reports]

    Full ArticleGraphical Abstract

    The Amot/Integrin Protein Complex Transmits Mechanical Forces Required for Vascular Expansion

    Investigators showed that deletion of the scaffold protein Angiomotin (Amot) inhibited migration and expansion of the physiological and pathological vascular network
    [Cell Reports]

    Full ArticleGraphical Abstract

    EPAS1 (Endothelial PAS Domain Protein 1) Orchestrates Transactivation of Endothelial ICAM1 (Intercellular Adhesion Molecule 1) by Small Nucleolar RNA Host Gene 5 (SNHG5 ) to Promote Hypoxic Pulmonary Hypertension

    Scientists confirmed that EPAS1-specific inhibitor PT2385 ameliorated HPH features, as demonstrated by right ventricle hypertrophy, right ventricular systolic pressure, and pulmonary vascular remodeling.
    [Hypertension]

    Abstract

    Role of Aneuploid Circulating Tumor Cells and CD31+ Circulating Tumor Endothelial Cells in Predicting and Monitoring Anti-angiogenic Therapy Efficacy in Advanced NSCLC

    Co-detection and comprehensive phenotypic and karyotypic molecular characterization of aneuploid circulating tumor cells and circulating tumor endothelial cells were conducted on non-small cell lung cancer patients receiving bevacizumab plus chemotherapy.
    [Molecular Oncology]

    Abstract

    C1q/Tumor Necrosis Factor-Related Protein-3 Improves Microvascular Endothelial Function in Diabetes through the AMPK/eNOS/NO· Signaling Pathway

    Investigators demonstrated that the C1q-like globular domain of C1q/tumor necrosis factor-related protein (CTRP)3, CTRP5, and CTRP9 exerted a vasorelaxant effect on the microvasculature, of which gCTRP3 was the most powerful one.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract

    KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression

    Utilizing stasis-induced murine deep vein thrombosis model and cultured endothelial cells, the authors identified an increase of KLF11 expression under prothrombotic conditions both in vivo and in vitro.
    [Thrombosis and Haemostasis]

    Abstract

    p300/Sp1-Mediated High Expression of p16 Promotes Endothelial Progenitor Cell Senescence Leading to the Occurrence of Chronic Obstructive Pulmonary Disease

    Peripheral blood endothelial progenitor cells were isolated from nonsmoking non-chronic obstructive pulmonary disease (COPD), smoking non-COPD, and smoking COPD patients. The expressions of p16, p300, and senescence-related genes were detected by RT-PCR and Western Blot.
    [Mediators of Inflammation]

    Full Article

    Irisin Enhances Angiogenesis of Mesenchymal Stem Cells to Promote Cardiac Function in Myocardial Infarction via PI3k/Akt Activation

    Researchers investigated the potential role of irisin in the angiogenesis of bone-marrow mesenchymal stem cells (BMSCs). In vivo, irisin-treated BMSCs were transplanted into an myocardial infarction mouse model.
    [International Journal of Stem Cells]

    Abstract
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    REVIEWS

    Putting Function Back in Dysfunction: Endothelial Diseases and Current Therapies in Hematopoietic Stem Cell Transplantation and Cellular Therapies

    Scientists summarize the current knowledge about statins and other agents used as endothelial protectants. They propose further studies using statins for prophylaxis and prevention of end-organ damage related to extensive endothelial dysfunction in hematopoietic stem cell transplantation and chimeric antigen receptor-T cells.
    [Blood Reviews]

    Abstract

    Targeting Senescent Cells for Vascular Aging and Related Diseases

    To emphasize the relationship between senescent cells and vascular aging, investigators summarize the roles of senescent vascular cells in the vascular aging process and inducers that contribute to cellular senescence.
    [Journal of Molecular and Cellular Cardiology]

    AbstractGraphical Abstract

    Building New Cardiac Vasculature and Myocardium

    The authors describe the latest advances in cell therapy, biomaterials and 3D bioprinting for the treatment of cardiovascular disease.
    [Current Opinion in Cardiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    HUTCHMED Initiates a Phase Ib/II Trial of Fruquintinib in Combination with Tislelizumab in Advanced Triple Negative Breast Cancer or Advanced Endometrial Cancer

    HUTCHMED initiated a Phase Ib/II study of fruquintinib in combination with BeiGene’s tislelizumab in patients with advanced triple negative breast cancer or advanced endometrial cancer in the US. This trial is to explore the potential for the addition of a highly selective vascular endothelial growth factor receptor inhibitor, fruquintinib, to anti-programmed death-1 antibody tislelizumab in inducing activity to immune checkpoint inhibitors.
    [HUTCHMED]

    Press Release

    FEATURED EVENT

    Brain Cancer

    October 21 – 24, 2021
    Portland, Oregon, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Biology of the Blood-Brain Barrier

    McGovern Medical School – Houston, Texas, United States

    Research Fellow – Microfluidic Models of Microvasculature

    University College London – London, England, United Kingdom

    Postdoctoral Research Fellow – Cardiac and Endothelial Cell Function

    Stanford University – La Jolla, California, United States

    Senior Scientist – Immuno-Oncology

    Epitopea – Cambridge, England, United Kingdom

    Development Engineer – Cell Therapies and Regenerative Medicine

    Danaher – Toronto, Ontario, Canada

    > See All Jobs

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