Endothelial Cell News Volume 6.31 | Sep 13 2021

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    Justin.choi
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    2021-09-13 | ENDOCN 6.31


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.31 – 13 September, 2021
    TOP STORY

    Microvessels Support Engraftment and Functionality of Human Islets and hESC-Derived Pancreatic Progenitors in Diabetes Models

    Scientists enhanced subcutaneous engraftment by employing a unique vascularization strategy based on ready-made microvessels isolated from the adipose tissue.
    [Cell Stem Cell]

    Abstract

    Explore virtual support and resources to stay productive and connected with your field.
    PUBLICATIONSRanked by the impact factor of the journal

    Perinatal Angiogenesis from Pre-Existing Coronary Vessels via DLL4–NOTCH1 Signaling

    Scientists showed that, in late fetal development, the embryonic coronary plexus at the inner myocardium of the ventricles expressed the angiogenic signaling factors VEGFR3 and DLL4 and generated new coronary vessels in neonates.
    [Nature Cell Biology]

    Abstract

    Heat Shock Protein 27 Activity Is Linked to Endothelial Barrier Recovery after Proinflammatory GPCR-Induced Disruption

    Through mass spectrometry phosphoproteomics, researchers identified heat shock protein 2, which exists as a large oligomer that binds to actin, as a promising candidate for the p38-mediated regulation of barrier integrity.
    [Science Signaling]

    Abstract

    Antihypertensive Drug Treatment and Susceptibility to SARS-CoV-2 Infection in Human PSC-Derived Cardiomyocytes and Primary Endothelial Cells

    Exposure of human pluripotent stem cell-derived cardiomyocytes and primary endothelial cells to SARS-CoV-2 identified significant differences in protein coding genes involved in immunity, viral response, and cardiomyocyte/endothelial structure.
    [Stem Cell Reports]

    AbstractFull Article

    Engineered 3D Vessel-on-Chip Using hiPSC-Derived Endothelial- and Vascular Smooth Muscle Cells

    The authors developed a robust multi-cell type 3D vessel-on-chip model based entirely on human induced pluripotent stem cells (hiPSCs). Within a fibrin hydrogel microenvironment, the hiPSC-derived vascular cells self-organized to form stable microvascular networks reproducibly, in which the vessels were lumenized and functional, responding as expected to vasoactive stimulation.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Potential Role of Epicardial Adipose Tissue in Coronary Artery Endothelial Cell Dysfunction in Type 2 Diabetes

    To simulate type 2 diabetes-associated metabolic and inflammatory status in an ex vivo tissue culture model, human epicardial adipose tissue (EAT) samples were treated with a cocktail composed of high glucose, high palmitate, and lipopolysaccharide and were compared with control EAT.
    [FASEB Journal]

    Abstract

    Effect of Endothelial Progenitor Cell-Derived Extracellular Vesicles on Endothelial Cell Ferroptosis and Atherosclerotic Vascular Endothelial Injury

    Researchers focused on the role of endothelial progenitor cell-secreted extracellular vesicles in atherosclerosis.
    [Cell Death Discovery]

    Full Article

    Tumor-Derived Exosomal miR-3157-3p Promotes Angiogenesis, Vascular Permeability and Metastasis by Targeting TIMP/KLF2 in Non-small Cell Lung Cancer

    Scientists found that miR-3157-3p could be transferred from non-small cell lung carcinoma cells to vascular endothelial cells through exosomes.
    [Cell Death Discovery]

    Full Article

    Construction of Transplantable Artificial Vascular Tissue Based on Adipose Tissue-Derived Mesenchymal Stromal Cells by a Cell Coating and Cryopreservation Technique

    The authors constructed an artificial vascular tissue constructed by human adipose tissue-derived stromal cells and HUVECs by a modified technique with cryopreservation.
    [Scientific Reports]

    Full Article

    Glutamine Metabolism Regulates Endothelial to Hematopoietic Transition and Hematopoietic Lineage Specification

    Researchers showed that glutamine was a crucial regulator of endothelial to hematopoietic transition and a rate limiting metabolite in the hematopoietic differentiation of hemogenic endothelial cells.
    [Scientific Reports]

    Full Article

    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Targeting Senescent Cells for Vascular Aging and Related Diseases

    To emphasize the relationship between senescent cells and vascular aging, scientists summarize the roles of senescent vascular cells in the vascular aging process and inducers that contribute to cellular senescence.
    [Journal of Molecular and Cellular Cardiology]

    AbstractGraphical Abstract

    Building New Cardiac Vasculature and Myocardium

    The authors describe the latest advances in cell therapy, biomaterials and 3D bioprinting for the treatment of cardiovascular disease.
    [Current Opinion in Cardiology]

    Abstract

    INDUSTRY AND POLICY NEWS

    BioRestorative Therapies Receives Patent in Australia Related to its Off-the-Shelf ThermoStem® Program

    BioRestorative Therapies, Inc. announced that the Australian Patent Office has issued the company a patent related to its metabolic ThermoStem® Program.
    [BioRestorative Therapies, Inc. (GlobeNewswire, Inc.)]

    Press Release

    HUTCHMED and AstraZeneca Initiate SANOVO Phase III Trial of ORPATHYS® and TAGRISSO® Combination as a First-Line Therapy for Certain Lung Cancer Patients in China

    HUTCHMED Limited and AstraZeneca PLChave initiated SANOVO, a China Phase III study of ORPATHYS®, an oral, potent, and highly selective MET tyrosine kinase inhibitor, in combination with AstraZeneca’s third-generation, irreversible epidermal growth factor receptor (EGFR) TKI, TAGRISSO® as a first-line treatment in certain non-small cell lung cancer patients whose tumors harbor EGFR mutation and overexpress MET.
    [HUTCHMED, Ltd.]

    Press Release

    FEATURED EVENT

    CRISPR and Beyond: Perturbations at Scale to Understand Genomes

    September 22 – 25, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Cardiovascular Research

    Queen’s University Belfast – Belfast, Ireland

    PhD Studentship – Lung Metastatic Niche

    CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom

    Postdoctoral Associate – Cardiovascular Biology and Disease Modeling

    Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States

    Postdoctoral Research Fellow – Cardiac and Endothelial Cell Function

    Stanford University – La Jolla, California, United States

    Senior Scientist – Immuno-Oncology

    Epitopea – Cambridge, England, United Kingdom

    > See All Jobs

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