Endothelial Cell News Volume 6.35 | Oct 18 2021

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    Justin.choi
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    2021-10-18 | ENDOCN 6.35


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.35 – 18 October, 2021
    TOP STORY

    Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity

    HUVECs were exposed to either laminar flow or oscillating disturbed flow for 24 hours in a cone-and-plate device.
    [Circulation Research]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Hexokinase 2-Driven Glycolysis in Pericytes Activates Their Contractility Leading to Tumor Blood Vessel Abnormalities

    The authors developed a method that combined magnetic beads and flow cytometry cell sorting to isolate pericytes from tumors and normal adjacent tissues from patients with non-small cell lung cancer and hepatocellular carcinoma.
    [Nature Communications]

    Full Article

    MARCO+ Lymphatic Endothelial Cells Sequester Arthritogenic Alphaviruses to Limit Viremia and Viral Dissemination

    Following subcutaneous inoculation, arthritogenic alphavirus particles drained via the lymph and were rapidly captured by MARCO+ lymphatic endothelial cells in the draining lymph node, limiting viral spread to the bloodstream.
    [EMBO Journal]

    AbstractGraphical Abstract

    Small Molecule Compound M12 Reduces Vascular Permeability in Obese Mice via Blocking Endothelial TRPV4–Nox2 Interaction

    Investigators showed that interrupting TRPV4–Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.
    [Acta Pharmacologica Sinica]

    Abstract

    Functional Characterization of a Bioengineered Liver after Heterotopic Implantation in Pigs

    Scientists reported a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver scaffold previously reendothelialized with human umbilical vein endothelial cells.
    [Communications Biology]

    Full Article

    Endothelial Cell-Derived Pro-Fibrotic Factors Increase TGF-β1 Expression by Smooth Muscle Cells in Response to Cycles of Hypoxia-Hyperoxia

    Researchers investigated the mechanisms by which pathological changes in the microvasculature direct fibrosis in the context of ischemia-reperfusion.
    [Biochimica Et Biophysica Acta-Molecular Basis of Disease]

    Full Article

    Brain Microvasculature Endothelial Cell Orientation on Micropatterned Hydrogels Is Affected by Glucose Level Variations

    The authors reported on an effort to decipher the alignment of brain microvasculature endothelial cells to physical constrains generated via adhesion control on hydrogel surfaces and explored the corresponding responses upon glucose level variations emulating the hypo- and hyperglycemic effects in diabetes.
    [Scientific Reports]

    Full Article

    sFlt-1 and CA 15.3 Are Indicators of Endothelial Damage and Pulmonary Fibrosis in SARS-CoV-2 Infection

    Scientists investigated the association of sFLT-1 and CA 15.3 with endothelial damage and pulmonary fibrosis.
    [Scientific Reports]

    Full Article

    Propranolol Inhibits the Angiogenic Capacity of Hemangioma Endothelia via Blocking β-Adrenoceptor in Mast Cell

    Hemangioma endothelial cells were co-cultured with propranolol-treated HMC-1s supernatants, and their proliferation and apoptosis were investigated.
    [Pediatric Research]

    Abstract

    SDF-1 Secreted by Mesenchymal Stem Cells Promotes the Migration of Endothelial Progenitor Cells via CXCR4/PI3K/AKT Pathway

    The authors investigated whether stromal cell-derived factor (SDF)-1 secreted by mesenchymal stem cells contributed to endothelial progenitor cell migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases/protein kinase B signaling pathway.
    [Journal of Molecular Histology]

    Abstract

    Calcium-Channel-Blockers Exhibit Divergent Regulation of Cancer Extravasation through the Mechanical Properties of Cancer Cells and Underlying Vascular Endothelial Cells

    Researchers examined the role of calcium-channel blocking drugs on mechanics of extravasating cancer cells, choosing two clinically-approved calcium-channel blockers as model antihypertensive drugs to simultaneously target cancer cells and an underlying monolayer of endothelial cells.
    [Cell Biochemistry and Biophysics]

    Abstract

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    REVIEWS

    3D Tumor Angiogenesis Models: Recent Advances and Challenges

    Scientists summarize recent advancements of 3D tumor vascular model systems which include tissue engineering-based tumor models; vascular organoid models, and organ-on-chips and their importance in replicating the tumor angiogenesis along with the associated challenges to design improved models.
    [Journal of Cancer Research and Clinical Oncology]

    Full Article

    Nutraceuticals and Their Role in Tumor Angiogenesis

    The literature concerning the pro-angiogenic and/or anti-angiogenic nutraceuticals and the possible activated pathways in cancer and other non-neoplastic diseases by in vivo and in vitro experiments are reviewed.
    [Experimental Cell Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    Merck and Eisai Receive Positive EU CHMP Opinions for KEYTRUDA® (Pembrolizumab) Plus LENVIMA® (Lenvatinib) in Two Different Types of Cancer

    Merck announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted positive opinions recommending approval of the combination of KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, for two different indications.
    [Merck (BusinessWire, Inc.)]

    Press Release

    Algernon Pharmaceuticals Files US FDA Pre-IND Meeting Request for Ifenprodil Chronic Cough Phase II Study

    Algernon Pharmaceuticals, Inc. announced that it has filed a pre-IND meeting request with the US FDA for its investigation of NP-120 for a planned Phase II study for the treatment of refractory chronic cough.
    [Algernon Pharmaceuticals, Inc.]

    Press Release

    FEATURED EVENT

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    JOB OPPORTUNITIES

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    Radboud University Medical Centre – Nijmegen, Netherlands

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    The University of New Mexico – Albuquerque, New Mexico, United State

    Faculty and Leadership Positions – Cancer-Focused Target and Drug Discovery

    The University of New Mexico – Albuquerque, New Mexico, United States

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