Endothelial Cell News Volume 6.36 | Oct 25 2021

May 12, 2022

2021-10-25 | ENDOCN 6.36

Endothelial Cell News by STEMCELL Technologies

Vol. 6.36 – 25 October, 2021

TOP STORY

Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation

In a model of genetically driven closure of choroid plexus endothelial cells, the authors observed a deficit in short-term memory and anxiety-like behavior, suggesting that choroid plexus closure might correlate with mental deficits.
[Science]

Abstract

Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.

PUBLICATIONSRanked by the impact factor of the journal

The SARS-CoV-2 Main Protease M^pro Causes Microvascular Brain Pathology by Cleaving NEMO in Brain Endothelial Cells

In brains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals and animal models, scientists found an increased number of empty basement membrane tubes, so-called string vessels representing remnants of lost capillaries.
[Nature Neuroscience]

Full Article

Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell–Fibroblast Crosstalk

Investigators proposed that IL-13 decreased TSPAN12, likely contributing to the chronicity of eosinophilic esophagitis by promoting tissue remodeling through fibroblast-endothelial cell crosstalk.
[Gastroenterology]

Abstract Graphical Abstract

Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Oxidative Stress-Induced Senescence in Endothelial Cells via Regulation of miR-146a/Src

In vitro results showed that MSC-small extracellular vesicles reduced senescent biomarkers, decreased senescence-associated secretory phenotype, rescued angiogenesis, migration and other dysfunctions in senescent endothelial cell induced by oxidative stress.
[Signal Transduction and Targeted Therapy]

Full Article

Inhibition of Mevalonate Metabolism by Statins Augments the Immunoregulatory Phenotype of Vascular Endothelial Cells and Inhibits the Costimulation of CD4⁺ T Cells

Researchers performed full transcriptomic RNA sequencing and qPCR to evaluate the effects of mevalonate on the immunoregulatory phenotype of endothelial cells.
[American Journal of Transplantation]

Full Article

Natriuretic Peptide Receptor a Promotes Gastric Malignancy through Angiogenesis Process

Natriuretic peptide receptor A protected HIF-1α from proteolysis by binding to HIF-1α, increased the expression of HIF-1α, and promoted gastric cancer angiogenesis.
[Cell Death & Disease]

Full Article

Inhibition of Hypoxia-Induced Mucin 1 Alters the Proteomic Composition of Human Osteoblast-Produced Extracellular Matrix, Leading to Reduced Osteogenic and Angiogenic Potential

Investigators assessed the Mucin 1-mediated effect of hypoxia on the proteomic composition of human osteoblast-derived extracellular matrices (ECM) and characterized their osteogenic and angiogenic potentials in the produced ECMs.
[Journal of Cellular Physiology]

Full Article

REDD1 Is a Determinant of Low-Dose Metronomic Doxorubicin-Elicited Endothelial Cell Dysfunction through Downregulation of VEGFR-2/3 Expression

Researchers examined the functional role of regulated in development and DNA damage responses 1 (REDD1), an inhibitor of mammalian target of rapamycin complex 1, in low-dose metronomic chemotherapy-mediated endothelial cell dysfunction.
[Experimental and Molecular Medicine]

Full Article

Mitigating the Non-Specific Uptake of Immunomagnetic Microparticles Enables the Extraction of Endothelium from Human Fat

The authors investigated the challenges underlying the overgrowth of human adipose tissue-derived microvascular endothelial cells by stromal cells to facilitate the development of a reliable method for their acquisition.
[Communications Biology]

Full Article

Antiangiogenic Antibody BD0801 Combined with Immune Checkpoint Inhibitors Achieves Synergistic Antitumor Activity and Affects the Tumor Microenvironment

The anti-cancer activities of BD0801 and its potential synergistic anti-tumor effects when combined with different immunotherapies were assessed by using in vitro assays and in vivo tumor models.
[BMC Cancer]

Full Article

Five tips for returning to the lab after time off

REVIEWS

Renal Microvascular Endothelial Cell Responses in Sepsis-Induced Acute Kidney Injury

Comprehensive studies are needed to investigate the relationships between segment-specific changes in the microvasculature and kidney function loss in sepsis-induced acute kidney injury.
[Nature Reviews Nephrology]

Abstract

INDUSTRY AND POLICY NEWS

FDA Approves Genentech’s New Treatment for Wet Age-Related Macular Degeneration (AMD)

The US FDA approved Susvimo^™ for intravitreal use via ocular implant for the treatment of people with wet, or neovascular, AMD who have previously responded to at least two anti-VEGF injections.
[Genentech]

Press Release

Servier
Announces Outcome from the Primary Analysis of the Phase III SOLSTICE Trial Assessing LONSURF^® (Trifluridine/Tipiracil) + Bevacizumab in a first Line Setting for Patients with Unresectable mCRC Non-Eligible for Intensive Therapy

Servier announced that the primary objective of the Phase III SOLSTICE trial has not been met. SOLSTICE was designed to evaluate the superiority of LONSURF^® + bevacizumab over capecitabine + bevacizumab in first line unresectable metastatic colorectal cancer (mCRC).
[Servier (Business Wire, Inc.)]

Press Release

FEATURED EVENT

Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation

The SARS-CoV-2 Main Protease M^pro Causes Microvascular Brain Pathology by Cleaving NEMO in Brain Endothelial Cells

Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell–Fibroblast Crosstalk

Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Oxidative Stress-Induced Senescence in Endothelial Cells via Regulation of miR-146a/Src

Inhibition of Mevalonate Metabolism by Statins Augments the Immunoregulatory Phenotype of Vascular Endothelial Cells and Inhibits the Costimulation of CD4⁺ T Cells

Natriuretic Peptide Receptor a Promotes Gastric Malignancy through Angiogenesis Process

Inhibition of Hypoxia-Induced Mucin 1 Alters the Proteomic Composition of Human Osteoblast-Produced Extracellular Matrix, Leading to Reduced Osteogenic and Angiogenic Potential

REDD1 Is a Determinant of Low-Dose Metronomic Doxorubicin-Elicited Endothelial Cell Dysfunction through Downregulation of VEGFR-2/3 Expression

Mitigating the Non-Specific Uptake of Immunomagnetic Microparticles Enables the Extraction of Endothelium from Human Fat

Antiangiogenic Antibody BD0801 Combined with Immune Checkpoint Inhibitors Achieves Synergistic Antitumor Activity and Affects the Tumor Microenvironment

Renal Microvascular Endothelial Cell Responses in Sepsis-Induced Acute Kidney Injury

FDA Approves Genentech’s New Treatment for Wet Age-Related Macular Degeneration (AMD)

Servier
Announces Outcome from the Primary Analysis of the Phase III SOLSTICE Trial Assessing LONSURF^® (Trifluridine/Tipiracil) + Bevacizumab in a first Line Setting for Patients with Unresectable mCRC Non-Eligible for Intensive Therapy

Cerebral Small Vessel Disease and Alzheimer’s Disease

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Research Technician – Retina-on-Chip

Postdoctoral Scientist – Translational Cancer Biology and Therapeutics

Postdoctoral Research Fellow – iPSC Reprogramming

Postdoctoral Position – Stem Cells and Disease Modeling

Postdoctoral Fellow – Biology of the Blood-Brain Barrier

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