Endothelial Cell News Volume 6.38 | Nov 8 2021

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    2021-11-08 | ENDO 6.38


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.38 – 8 November, 2021
    TOP STORY

    Anti-Angiogenic Nanomicelles For the Topical Delivery of Aflibercept to Treat Retinal Neovascular Disease

    Scientists reported a nanomicelle drug delivery system made of a co-polymer endothelial progenitor cells, which was capable of delivering aflibercept to the posterior segment topically through corneal-scleral routes.
    [Advanced Materials]

    Abstract


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    PUBLICATIONSRanked by the impact factor of the journal

    The RNA Helicase Ddx21 Controls Vegfc-Driven Developmental Lymphangiogenesis by Balancing Endothelial Cell Ribosome Biogenesis and p53 Function

    Scientists showed that Ddx21 was enriched in sprouting venous endothelial cells in response to Vegfc–Flt4 signalling. Ddx21 function was essential for Vegfc–Flt4-driven endothelial cell proliferation.
    [Nature Cell Biology]

    Abstract

    Endothelial Deletion of SHP2 Suppresses Tumor Angiogenesis and Promotes Vascular Normalization

    Investigators showed that SHP2 was activated in tumor endothelia. Shp2 deletion and pharmacological inhibition reduced tumor growth and microvascular density in multiple mouse tumor models.
    [Nature Communications]

    Full Article

    Functional Delivery of lncRNA TUG1 by Endothelial Progenitor Cells Derived Extracellular Vesicles Confers Anti-inflammatory Macrophage Polarization in Sepsis via Impairing miR-9-5p-Targeted SIRT1 Inhibition

    Researchers explored the role of endothelial progenitor cells derived extracellular vesicles transmitting taurine upregulated gene 1 (TUG1) in macrophage polarization and macrophage-mediated inflammation in a cecal ligation and puncture-induced sepsis mouse model.
    [Cell Death & Disease]

    Full Article

    Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis

    Scientists defined for the first time an unexpected role of endothelial PHD2 deficiency in inducing cardiac hypertrophy and fibrosis in an HIF‐2α–dependent manner.
    [Journal of the American Heart Association]

    Full Article

    Endothelial Repair by Stem and Progenitor Cells

    By administration of new techniques, including genetic cell lineage tracing and single cell RNA sequencing, more solid data were obtained that support the concept of stem/progenitor cells for regenerating damaged endothelium.
    [Journal of Molecular and Cellular Cardiology]

    Abstract

    Vascularization of iNSC Spheroid in a 3D Spheroid-on-a-Chip Platform Enhances Neural Maturation

    Investigators created a 3D model of vascularized spheroid cells using an injection-molded microfluidic chip. Gene expression analysis and immunostaining revealed that the vascular network greatly enhanced spheroid differentiation and reduced apoptosis.
    [Biotechnology and Bioengineering]

    Full Article

    Human Endothelial Cells and Fibroblasts Express and Produce the Coagulation Proteins Necessary for Thrombin Generation

    Researchers described experiments that detailed the expression and production in endothelial cells (EC) and fibroblasts of the clotting proteins necessary for formation of active prothrombinase complexes to produce thrombin on EC and fibroblast surfaces.
    [Scientific Reports]

    Full Article

    PEDF Is an Endogenous Inhibitor of VEGF-R2 Angiogenesis Signaling in Endothelial Cells

    Scientists showed that pigment epithelium derived factor (PEDF) prevented early mitogenic signals of vascular endothelial growth factor in primate retinal endothelial cells, blocking proliferation, migration and tube formation.
    [Experimental Eye Research]

    Abstract

    Bone Mesenchymal Stem Cells-Derived miR-223-3p-Containing Exosomes Ameliorate Lipopolysaccharide-Induced Acute Uterine Injury via Interacting with Endothelial Progenitor Cells

    Lipopolysaccharide was used to induce intrauterine adhesion in mice models and endothelial progenitor cells to mimic the realistic pathogenesis of intrauterine adhesion in vivo and in vitro.
    [Bioengineered]

    Full Article

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    REVIEWS

    Opening the Window for Endothelial-to-Hematopoietic Transition

    Scientists highlight interesting parallels between endothelial-to-hematopoietic transition and endothelial-to-mesenchymal transition, which occurs during cardiac development.
    [Genes & Development]

    Abstract

    INDUSTRY AND POLICY NEWS

    Cardiovascular Systems, Inc. Announces First In-Human Experience with Coronary Everolimus Drug Coated Balloon

    Cardiovascular Systems, Inc. announced the start of enrollment in a first-in-human trial of the coronary everolimus drug-coated balloon being developed by Chansu Vascular Technologies, LLC.
    [Cardiovascular Systems, Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Biological Assemblies: Phase Transitions

    November 1 – 3, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Endothelial Cell Migration

    University of California Los Angeles – Los Angeles, California, United States

    Scientist – iPSC Derived Cardiac Tissues

    Columbia University – New York, New York, United States

    Research Technician – Retina-on-Chip

    Radboud University Medical Center – Nijmegen, The Netherlands

    Associate Professor – Translational Skin Cancer

    Columbia University Medical Center – New York, New York, United States

    Postdoctoral Research Fellow – iPSC Reprogramming

    Northwestern University – Chicago, Illinois, United States

    > See All Jobs

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