| Vol. 6.38 – 8 November, 2021 |
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| Scientists reported a nanomicelle drug delivery system made of a co-polymer endothelial progenitor cells, which was capable of delivering aflibercept to the posterior segment topically through corneal-scleral routes. [Advanced Materials] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that Ddx21 was enriched in sprouting venous endothelial cells in response to Vegfc–Flt4 signalling. Ddx21 function was essential for Vegfc–Flt4-driven endothelial cell proliferation. [Nature Cell Biology] |
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| Investigators showed that SHP2 was activated in tumor endothelia. Shp2 deletion and pharmacological inhibition reduced tumor growth and microvascular density in multiple mouse tumor models. [Nature Communications] |
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| Researchers explored the role of endothelial progenitor cells derived extracellular vesicles transmitting taurine upregulated gene 1 (TUG1) in macrophage polarization and macrophage-mediated inflammation in a cecal ligation and puncture-induced sepsis mouse model. [Cell Death & Disease] |
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| Scientists defined for the first time an unexpected role of endothelial PHD2 deficiency in inducing cardiac hypertrophy and fibrosis in an HIF‐2α–dependent manner. [Journal of the American Heart Association] |
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| By administration of new techniques, including genetic cell lineage tracing and single cell RNA sequencing, more solid data were obtained that support the concept of stem/progenitor cells for regenerating damaged endothelium. [Journal of Molecular and Cellular Cardiology] |
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| Investigators created a 3D model of vascularized spheroid cells using an injection-molded microfluidic chip. Gene expression analysis and immunostaining revealed that the vascular network greatly enhanced spheroid differentiation and reduced apoptosis. [Biotechnology and Bioengineering] |
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| Researchers described experiments that detailed the expression and production in endothelial cells (EC) and fibroblasts of the clotting proteins necessary for formation of active prothrombinase complexes to produce thrombin on EC and fibroblast surfaces. [Scientific Reports] |
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| Scientists showed that pigment epithelium derived factor (PEDF) prevented early mitogenic signals of vascular endothelial growth factor in primate retinal endothelial cells, blocking proliferation, migration and tube formation. [Experimental Eye Research] |
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| Lipopolysaccharide was used to induce intrauterine adhesion in mice models and endothelial progenitor cells to mimic the realistic pathogenesis of intrauterine adhesion in vivo and in vitro. [Bioengineered] |
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| Scientists highlight interesting parallels between endothelial-to-hematopoietic transition and endothelial-to-mesenchymal transition, which occurs during cardiac development. [Genes & Development] |
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| Cardiovascular Systems, Inc. announced the start of enrollment in a first-in-human trial of the coronary everolimus drug-coated balloon being developed by Chansu Vascular Technologies, LLC. [Cardiovascular Systems, Inc. (BusinessWire, Inc.)] |
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| November 1 – 3, 2021 Virtual |
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| University of California Los Angeles – Los Angeles, California, United States |
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| Columbia University – New York, New York, United States |
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| Radboud University Medical Center – Nijmegen, The Netherlands |
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| Columbia University Medical Center – New York, New York, United States |
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| Northwestern University – Chicago, Illinois, United States |
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