Endothelial Cell News Volume 6.40 | Nov 22 2021

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    2021-11-22 | ENDOCN 6.40


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.40 – 22 November, 2021
    TOP STORY

    Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells during Cardiac Fibrosis

    Genetic fate mapping results revealed that a subset of cardiac endothelial cells transiently expressed αSMA and Zeb1 during embryonic valve formation and transdifferentiated into mesenchymal cells through EndoMT.
    [Circulation]

    AbstractFull Article

    Watch 'collaborating to accelerate COVID-19 research'
    PUBLICATIONSRanked by the impact factor of the journal

    Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses

    The authors identified the protein syndesmos to specifically interact with cZNF292 in endothelial cells by RNA affinity purification and subsequent mass spectrometry analysis.
    [Circulation Research]

    AbstractFull Article

    VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling

    VE-cadherin was an essential scaffolding protein to maintain pro-lymphangiogenic signaling nodes at the plasma membrane, which was required for the development and adult maintenance of cardiac lymphatics, but not for cardiac function basally or after injury.
    [Circulation Research]

    Abstract

    Mapping Protein Carboxymethylation Sites Provides Insights into Their Role in Proteostasis and Cell Proliferation

    In primary endothelial cells, investigators showed that glyoxal induced cell cycle perturbation and that carboxymethyllysine modification reduced acetylation of tubulins and impaired microtubule dynamics.
    [Nature Communications]

    Full Article

    Multimodal On-Chip Nanoscopy and Quantitative Phase Imaging Reveals the Nanoscale Morphology of Liver Sinusoidal Endothelial Cells

    Researchers presented an integrated chip-based optical nanoscopy combined with quantitative phase microscopy to obtain 3D morphology of liver sinusoidal endothelial cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    LIF, a Mitogen for Choroidal Endothelial Cells, Protects the Choriocapillaris: Implications for Prevention of Geographic Atrophy

    Scientists identified leukemia inhibitory factor (LIF) as a mitogen for bovine choroidal endothelial cell (EC), although LIF had been mainly characterized as an EC growth inhibitor and an anti-angiogenic molecule.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Combination of Human Endothelial Colony-Forming Cells and Mesenchymal Stromal Cells Exert Neuroprotective Effects in the Growth-Restricted Newborn

    The authors examined whether pure fetal mesenchymal stromal cells and endothelial colony-forming cells from the human term placenta were neuroprotective through modulating neuroinflammation and supporting the brain vasculature.
    [NPJ Regenerative Medicine]

    Full Article

    VEGF-A, PDGF-BB and HB-EGF Engineered for Promiscuous Super Affinity to the Extracellular Matrix Improve Wound Healing in a Model of Type 1 Diabetes

    In the type 1 diabetic NOD mouse model, engineered growth factors improved both re-epithelialization and granulation tissue formation.
    [NPJ Regenerative Medicine]

    Full Article

    Perfluorooctane Sulfonic Acid (PFOS) Inhibits Vessel Formation in a Human 3D Co-Culture Angiogenesis Model (NCFs/HUVECs)

    Investigators found that in terms of metabolic activity, endothelial cells were much more sensitive to PFOS than fibroblasts or epithelial cells, and concluded that PFOS possesses antiangiogenic properties.
    [Environmental Pollution]

    AbstractGraphical Abstract

    Perivascular Adipose Tissue-Derived Nitric Oxide Compensates Endothelial Dysfunction in Aged Pre-Atherosclerotic Apolipoprotein E-Deficient Rats

    Scientists captured a novel mechanism by which inflammatory perivascular adipose tissue compensated severe endothelial dysfunction by contributing nitric oxide upon cholinergic stimulation.
    [Vascular Pharmacology]

    Abstract

    Modulation of Cell Signaling and Sulfation in Cardiovascular Development and Disease

    Immunocytochemical analysis confirmed SULF1/SULF2 expression in endothelial cell lining of blood vessels and in developing cardiomyocytes, but not in the adult cardiomyocytes despite persisting at reduced levels in the adult endothelial cells.
    [Scientific Reports]

    Full Article

    Developing a Pro-Angiogenic Placenta Derived Amniochorionic Scaffold with Two Exposed Basement Membranes as Substrates for Cultivating Endothelial Cells

    An optimized combination of enzymatic solutions with mechanical scrapping was used to remove the amniotic epithelium and chorion trophoblastic layer of a placenta membrane, which resulted in exposing the basement membranes of both sides without their separation and subsequent damages to the in-between spongy layer.
    [Scientific Reports]

    Full Article

    The Effect of Endocrine Disrupting Chemicals on the Vitronectin-Receptor (Integrin αvβ3)-Mediated Cell Adhesion of Human Umbilical Vein Endothelial Cells

    Vitronectin receptor (VTNR)-expressing HUVECs were used to determine the effects of endocrine disrupting chemicals and endogenous hormones on cell adhesion to vitronectin-coated surfaces, and on VTNR activation.
    [Toxicology in Vitro]

    Abstract

    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    A Fresh Look at Coronary Microembolization

    The authors characterize the features and mechanisms of coronary microembolization and discuss the clinical trials of drugs and devices for prevention and treatment.
    [Nature Reviews Cardiology]

    Full Article

    Developmental Angiocrine Diversification of Endothelial Cells for Organotypic Regeneration

    Scientists describe how microenvironmental tissue-specific biophysical, biochemical, immune, and inflammatory cues dictate the specialization of endothelial cells with zonated functions.
    [Developmental Cell]

    Abstract

    Developmental Angiocrine Diversification of Endothelial Cells for Organotypic Regeneration

    Investigators describe how microenvironmental tissue-specific biophysical, biochemical, immune, and inflammatory cues dictate the specialization of endothelial cells with zonated functions.
    [Developmental Cell]

    Abstract

    INDUSTRY AND POLICY NEWS

    Denali Therapeutics Announces Strategic Partner Takeda Exercises Option to Co-Develop and Co-Commercialize DNL593 (PTV:PGRN)

    Denali Therapeutics, Inc. announced that its strategic partner Takeda Pharmaceutical Company Limited has exercised an option to co-develop and co-commercialize DNL593, an investigational, brain-penetrant progranulin replacement therapy for the potential treatment of frontotemporal dementia-granulin.
    [Denali Therapeutics, Inc.]

    Press Release

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    January 16 – 20, 2022
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    JOB OPPORTUNITIES

    Researcher – Cell Biologist

    Accession Therapeutics – Oxford, England, United Kingdom

    Postdoctoral Researcher – Endothelial Cell Migration

    University of California Los Angeles – Los Angeles, California, United States

    Lecturer – Biomaterials and Tissue Engineering

    The University of Sheffield – Sheffield, England, United Kingdom

    Postdoctoral Research Fellow – Mammalian Synthetic Biology and Organoid Engineering

    The University of British Columbia – Vancouver, British Columbia, Canada

    Scientist – iPSC Derived Cardiac Tissues

    Columbia University – New York, New York, United States

    > See All Jobs

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