Endothelial Cell News Volume 7.00 | Jan 10 2022

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    2022-01-10 | ENDOCN 7.00


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.00 – 10 January, 2022
    TOP STORY

    FSAP Aggravated Endothelial Dysfunction and Neurological Deficits in Acute Ischemic Stroke Due to Large Vessel Occlusion

    To screen the potential biomarkers of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), proteomic analysis was performed to identify those distinct plasma protein profiles in AIS due to LVO with different collateral status.
    [Signal Transduction and Targeted Therapy]

    Full Article
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    miR-125a-5p Attenuates Macrophage-Mediated Vascular Dysfunction by Targeting Ninjurin1

    Researchers investigated the role of Ninj1 in physiological and pathological conditions and developed a strategy to regulate Ninj1 using specific miRNAs under pathological conditions.
    [Cell Death & Differentiation]

    Full Article

    Engineered Human Blood–Brain Barrier Microfluidic Model for Vascular Permeability Analysis

    The authors described an in vitro model of the human blood–brain barrier self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes.
    [Nature Protocols]

    Full Article

    Topical Application of TAK1 Inhibitor Encapsulated by Gelatin Particle Alleviates Corneal Neovascularization

    Scientists demonstrated that transforming growth factor-β-activated kinase 1 (TAK1) played an important role in the pathogenesis of corneal neovascularization.
    [Theranostics]

    Full ArticleGraphical Abstract

    Non-Invasive Longitudinal Imaging of VEGF-Induced Microvascular Alterations in Skin Wounds

    Researchers reported on non-invasive longitudinal imaging of the wound healing process in transgenic mice overexpressing VEGF A in keratinocytes by means of large-scale optoacoustic microscopy.
    [Theranostics]

    Full ArticleGraphical Abstract

    CXCL4 Drives Fibrosis by Promoting Several Key Cellular and Molecular Processes

    Investigators confirmed that CXCL4 directly induced myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Robust Genome Editing in Adult Vascular Endothelium by Nanoparticle Delivery of CRISPR-Cas9 Plasmid DNA

    A single intravenous administration of mixture of nanoparticles and plasmid DNA expressing Cas9 controlled by CDH5 promoter and guide RNA induced highly efficient genome editing in endothelial cells of the vasculatures, including lung, heart, aorta, and peripheral vessels in adult mice.
    [Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract

    CU06-1004 Enhances Vascular Integrity and Improves Cardiac Remodeling by Suppressing Edema and Inflammation in Myocardial Ischemia–Reperfusion Injury

    Investigators found that CU06-1004, as a vascular leakage blocker, could improve cardiac function by inhibiting cardiac microvascular endothelial cells’ hyperpermeability and subsequently reducing the neutrophil’s plugging and infiltration in infarcted hearts.
    [Experimental and Molecular Medicine]

    Full Article

    High Content Image Analysis to Study Phenotypic Heterogeneity in Endothelial Cell Monolayers

    Scientists developed an endothelial cell (EC) profiling tool (ECPT) to examine individual cells within intact monolayers. They used ECPT to characterize different phenotypes in arterial, venous and microvascular EC populations.
    [Journal of Cell Science]

    Abstract

    Deep Models of Integrated Multiscale Molecular Data Decipher the Endothelial Cell Response to Ionizing Radiation

    Researchers captured the kinetics of multi-omics layers, such as miRNome, targeted transcriptome, proteome, and metabolome, in irradiated primary human endothelial cells cultured in vitro.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Endothelial-Derived Extracellular MicroRNA-92a Promotes Arterial Stiffness by Regulating Phenotype Changes of Vascular Smooth Muscle Cells

    The authors investigated the role of endothelial-derived extracellular microRNA-92a in promoting arterial stiffness by regulating endothelial cell–vascular smooth muscle cell communication.
    [Scientific Reports]

    Full Article

    Lysosomal Acid Lipase Promotes Endothelial Proliferation in Cold-Activated Adipose Tissue

    Investigators provided in vivo evidence that lysosomal acid lipase-deficiency impaired the proliferation of endothelial cells in thermogenic adipose tissue.
    [Adipocyte]

    Full Article
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    REVIEWS

    Large-Vessel Vasculitis

    Scientists highlight the substantial heterogeneity present within large-vessel vasculitis and the importance of an individualized therapeutic approach.
    [Nature Reviews Disease Primers]

    Abstract

    Vasculopathy in COVID-19

    The authors address the vasculopathy of COVID-19 with a focus on the role of the endothelium in orchestrating the systemic response to SARS-CoV-2 infection.
    [Blood]

    Abstract
    INDUSTRY AND POLICY NEWS

    Researchers Awarded Grant to Study New Method of Islet Transplantation

    Weill Cornell Medicine researchers have received a two-year $500,000 grant from JDRF to evaluate an innovative approach to islet cell transplantation, an experimental treatment for difficult-to-control type 1 diabetes.
    [Weill Cornell Medicine]

    Press Release
    FEATURED EVENT

    Nature Conference – Breaking Barriers for Gender Equity Through LEAP

    8 March, 2022
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Technician – Vascular Development

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Research Group Leader – Therapy Resistance

    German Cancer Research Center – Frankfurt, Germany

    Postdoctoral Fellows – Hypertension and Cardiorenal Diseases

    University of Mississippi Medical Center – Jackson, Mississippi, United States

    MD/PhD Students – Inflammatory & Cellular Stress Signaling

    University Hospital of Cologne – Cologne, Germany

    Researcher – Cell Biologist

    Accession Therapeutics – Oxford, England, United Kingdom

    > See All Jobs

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