Endothelial Cell News Volume 7.01 | Jan 17 2022

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    2022-01-17 | ENDOCN 7.01


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.01 – 17 January, 2022
    TOP STORY

    Cysteine Oxidation of Copper Transporter CTR1 Drives VEGFR2 Signaling and Angiogenesis

    Oxidation of CTR1 at Cys189 promoted VEGFR2 internalization and signaling to enhance angiogenesis. Scientists uncovered an important mechanism for sensing reactive oxygen species through CTR1 to drive neovascularization.
    [Nature Cell Biology]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Pre-Configuring Chromatin Architecture with Histone Modifications Guides Hematopoietic Stem Cell Formation in Mouse Embryos

    The authors performed multi-omics dissection of the hematopoietic stem cell (HSC) ontogeny trajectory across early arterial endothelial cells (ECs), hemogenic ECs, pre-HSCs and long-term HSCs in mouse embryos.
    [Nature Communications]

    Full Article

    Eukaryotic Initiation Factor 6 Regulates Mechanical Responses in Endothelial Cells

    Researchers showed that eukaryotic initiation factor 6 (eIF6) was required for the correct spatial mechanoactivation of ERK1/2 via stabilization of an eIF6–RACK1–ERK1/2–FAK mechanocomplex
    [Journal of Cell Biology]

    Full Article

    Angiogenesis Depends upon EPHB4-Mediated Export of Collagen IV from Vascular Endothelial Cells

    Investigators showed that induced endothelial cell (EC)-specific disruption of Ephb4 in mice resulted in accumulation of collagen IV in the EC endoplasmic reticulum leading to EC apoptotic death and defective developmental, neonatal and pathological angiogenesis.
    [JCI Insight]

    AbstractFull Article

    Endothelial Thrombomodulin Downregulation Caused by Hypoxia Contributes to Severe Infiltration and Coagulopathy in COVID-19 Patient Lungs

    Pulmonary endothelial cells become dysfunctional during COVID-19, showing a loss of thrombomodulin expression related to severe thrombosis and infiltration, and endothelial cell dysfunction might be caused by a pathologic condition in COVID-19 patient lungs rather than a direct infection with SARS-CoV-2.
    [Ebiomedicine]

    Full Article

    Thymosin Beta-4 Improves Endothelial Function and Reparative Potency of Diabetic Endothelial Cells Differentiated from Patient Induced Pluripotent Stem Cells

    Scientists assessed the role of thymosin β-4 on endothelial function using diabetic human induced pluripotent stem cells derived endothelial cells as disease model of endothelial dysfunction.
    [Stem Cell Research & Therapy]

    Full Article

    AMIGO2 Contained in Cancer Cell-Derived Extracellular Vesicles Enhances the Adhesion of Liver Endothelial Cells to Cancer Cells

    Researchers explored the role of cancer cell-derived amphoterin-induced gene and open reading frame 2 (AMIGO2)-containing extracellular vesicles in the adhesion of cancer cells to human hepatic sinusoidal endothelial cells.
    [Scientific Reports]

    Full Article

    miR-548j-5p Regulates Angiogenesis in Peripheral Artery Disease

    The effects of specific miRNAs on angiogenesis were evaluated by assessing the in vitro angiogenic function of endothelial progenitor cells, performing an in vivo angiogenesis assay, and employing a mouse hindlimb ischemic model.
    [Scientific Reports]

    Full Article

    Liraglutide Prevents High Glucose Induced HUVECs Dysfunction via Inhibition of PINK1/Parkin-Dependent Mitophagy

    Investigators characterized the potential effects of liraglutide, a glucagon-like peptide-1 receptor agonist, on preventing high glucose-induced endothelial dysfunction and excessive mitophagic response.
    [Molecular and Cellular Endocrinology]

    Full Article

    Dapagliflozin Exerts Anti-Inflammatory Effects via Inhibition of LPS-Induced TLR-4 Overexpression and NF-κB Activation in Human Endothelial Cells and Differentiated Macrophages

    Researchers assessed the direct anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors dapagliflozin on two cell types involved in the process of atherogenesis.
    [European Journal of Pharmacology]

    AbstractGraphical Abstract

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    REVIEWS

    Tumors Resurrect an Embryonic Vascular Program to Escape Immunity

    It is assumed that angiogenesis-induced suppression of adhesion molecules is a regulatory function to provide an embryo with immune-privileged conditions and allow uninterrupted growth and development. It is becoming clear that similar conditions are used by tumors to evade the immune system.
    [Science Immunology]

    Abstract

    Cardiovascular Ramifications of Therapy-Induced Endothelial Cell Senescence in Cancer Survivors

    The authors discuss the mechanisms of cancer therapy-induced senescence, focusing on endothelial cell senescence since it has been shown to be a key player in numerous cardiovascular complications.
    [Biochimica Et Biophysica Acta-Molecular Basis of Disease]

    Abstract

    INDUSTRY AND POLICY NEWS

    Exact Sciences and OncXerna Announce Licensing Agreement to Help Predict Immunotherapy Response for More Patients

    Exact Sciences Corp. and OncXerna Therapeutics, Inc. announced they have entered an exclusive license agreement to bring OncXerna’s Xerna tumor microenvironment (TME) Panel lab services to more US patients.
    [Exact Sciences Corporation]

    Press Release

    REGENXBIO Announces Initiation of Second Pivotal Trial in RGX-314 Clinical Program for the Treatment of Wet AMD Using Subretinal Delivery

    REGENXBIO, Inc. announced the initiation of ASCENTTM, the second of two Phase III pivotal trials to evaluate the efficacy and safety of subretinal delivery of RGX-314 in patients with wet age-related macular degeneration (wet AMD).
    [REGENXBIO, Inc.]

    Press Release

    FEATURED EVENT

    Keystone Symposia – Oncology of Infectious Diseases

    February 6 – 10, 2022
    Banff, Alberta, Canada

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    JOB OPPORTUNITIES

    Research Scientist – Cardiobiology

    Ksilink – Strasbourg, France

    Research Assistant – Regenerative Medicine

    Howard Hughes Medical Institute – Dallas, Texas, United States

    MD/PhD Students – Inflammatory & Cellular Stress Signaling

    University Hospital of Cologne – Cologne, Germany

    Research Group Leader – Therapy Resistance

    German Cancer Research Center – Frankfurt, Germany

    Postdoctoral Fellows – Hypertension and Cardiorenal Diseases

    University of Mississippi Medical Center – Jackson, Mississippi, United States

    > See All Jobs

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