| Vol. 7.01 – 17 January, 2022 |
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| Oxidation of CTR1 at Cys189 promoted VEGFR2 internalization and signaling to enhance angiogenesis. Scientists uncovered an important mechanism for sensing reactive oxygen species through CTR1 to drive neovascularization. [Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors performed multi-omics dissection of the hematopoietic stem cell (HSC) ontogeny trajectory across early arterial endothelial cells (ECs), hemogenic ECs, pre-HSCs and long-term HSCs in mouse embryos. [Nature Communications] |
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| Researchers showed that eukaryotic initiation factor 6 (eIF6) was required for the correct spatial mechanoactivation of ERK1/2 via stabilization of an eIF6–RACK1–ERK1/2–FAK mechanocomplex [Journal of Cell Biology] |
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| Investigators showed that induced endothelial cell (EC)-specific disruption of Ephb4 in mice resulted in accumulation of collagen IV in the EC endoplasmic reticulum leading to EC apoptotic death and defective developmental, neonatal and pathological angiogenesis. [JCI Insight] |
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| Pulmonary endothelial cells become dysfunctional during COVID-19, showing a loss of thrombomodulin expression related to severe thrombosis and infiltration, and endothelial cell dysfunction might be caused by a pathologic condition in COVID-19 patient lungs rather than a direct infection with SARS-CoV-2. [Ebiomedicine] |
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| Scientists assessed the role of thymosin β-4 on endothelial function using diabetic human induced pluripotent stem cells derived endothelial cells as disease model of endothelial dysfunction. [Stem Cell Research & Therapy] |
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| Researchers explored the role of cancer cell-derived amphoterin-induced gene and open reading frame 2 (AMIGO2)-containing extracellular vesicles in the adhesion of cancer cells to human hepatic sinusoidal endothelial cells. [Scientific Reports] |
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| The effects of specific miRNAs on angiogenesis were evaluated by assessing the in vitro angiogenic function of endothelial progenitor cells, performing an in vivo angiogenesis assay, and employing a mouse hindlimb ischemic model. [Scientific Reports] |
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| Investigators characterized the potential effects of liraglutide, a glucagon-like peptide-1 receptor agonist, on preventing high glucose-induced endothelial dysfunction and excessive mitophagic response. [Molecular and Cellular Endocrinology] |
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| Researchers assessed the direct anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors dapagliflozin on two cell types involved in the process of atherogenesis. [European Journal of Pharmacology] |
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| It is assumed that angiogenesis-induced suppression of adhesion molecules is a regulatory function to provide an embryo with immune-privileged conditions and allow uninterrupted growth and development. It is becoming clear that similar conditions are used by tumors to evade the immune system. [Science Immunology] |
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| The authors discuss the mechanisms of cancer therapy-induced senescence, focusing on endothelial cell senescence since it has been shown to be a key player in numerous cardiovascular complications. [Biochimica Et Biophysica Acta-Molecular Basis of Disease] |
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| Exact Sciences Corp. and OncXerna Therapeutics, Inc. announced they have entered an exclusive license agreement to bring OncXerna’s Xerna tumor microenvironment (TME) Panel lab services to more US patients. [Exact Sciences Corporation] |
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| REGENXBIO, Inc. announced the initiation of ASCENTTM, the second of two Phase III pivotal trials to evaluate the efficacy and safety of subretinal delivery of RGX-314 in patients with wet age-related macular degeneration (wet AMD). [REGENXBIO, Inc.] |
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| February 6 – 10, 2022 Banff, Alberta, Canada |
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| Ksilink – Strasbourg, France |
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| Howard Hughes Medical Institute – Dallas, Texas, United States |
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| University Hospital of Cologne – Cologne, Germany |
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| German Cancer Research Center – Frankfurt, Germany |
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| University of Mississippi Medical Center – Jackson, Mississippi, United States |
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