 | | Vol. 7.02 – 24 January, 2022 |
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| The healthy human neutrophil secretome generated under normoxic or hypoxic conditions was characterized by quantitative mass spectrometry, and the capacity for neutrophil-mediated endothelial damage assessed.
[American Journal of Respiratory and Critical Care Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors provided experimental evidence demonstrating a previously unidentified causal role of disturbed flow-induced endothelial thioredoxin domain containing 5 (TXNDC5) in atherosclerosis.
[Science Advances] |
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| Transient recombinase system treatment of endothelial cells, differentiated from patient-derived induced pluripotent stem cells of a hemophilic donor, resulted in 12% correction of the inversion and restored Factor VIII mRNA expression.
[Nature Communications] |
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| Researchers showed that vascular regression induced by VEGFR2 deletion in postnatal and adult mice was aggravated by additional deletion of VEGFR1 or VEGFR3 in the intestine, kidney, and pancreas, but not in the liver or kidney glomeruli.
[Journal of Experimental Medicine] |
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| Scientists reported that VEGF signaling at the luminal side of the brain microvasculature played an integral role in the capillary stalling phenomenon of the APP/PS1 mouse model.
[Brain] |
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| Investigators demonstrated that human central memory cytotoxic T lymphocytes (CTLs) crossed the endothelium in a predominantly paracellular fashion, whereas effector and effector memory CTLs crossed the endothelium preferably in a transcellular fashion.
[Cell Reports] |
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| The authors explored the role of cancer cell-derived amphoterin-induced gene and open reading frame 2 (AMIGO2)-containing extracellular vesicles in the adhesion of cancer cells to human hepatic sinusoidal endothelial cells.
[Scientific Reports] |
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| Scientists investigated the role of maternally expressed gene 8 (MEG8) specifically in endothelial function as well as the underlying mechanism, hypothesizing that it plays an important role in cardiovascular disease via epigenetic regulation of gene expression.
[Scientific Reports] |
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| Investigators found that communication network factor 2 (CCN2) induced phosphorylation of ERK in primary cultured lymphatic endothelial cells, which was almost completely inhibited by the blockade of integrin αvβ5 and partially decreased by the blockade of integrin αvβ3.
[Scientific Reports] |
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| The authors summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.
[Acta Pharmacologica Sinica] |
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| Scientists discuss the recent works regarding the use of cell therapy to improve allograft outcomes.
[Biomedical Journal] |
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| Vasomune Therapeutics, Inc. announced it has dosed the first patient in the Phase IIa clinical study to evaluate AV-001 in patients hospitalized with severe COVID-19 disease.
[Vasomune Therapeutics, Inc.] |
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| Compass Therapeutics, Inc. announced that the FDA has cleared its IND application for CTX-009, enabling the company to initiate a global Phase II clinical trial for CTX-009 in patients who have advanced Biliary Tract Cancers in the United States and South Korea.
[Compass Therapeutics, Inc.] |
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| March 9 – 11, 2022
Melbourne, Victoria, Australia |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Columbia University – New York, New York, United States |
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| Ksilink – Strasbourg, France |
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| | Howard Hughes Medical Institute – Dallas, Texas, United States |
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| | University Hospital of Cologne – Cologne, Germany |
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