 | | Vol. 7.03 – 31 January, 2022 |
| |
|
|
| Investigators profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity.
[Science] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists constructed the single-cell transcriptomic landscape of vascular endothelial cells during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos.
[Cell Research] |
|
|
|
| The authors showed that toll/interleukin-1 receptor domain containing adaptor protein (TIRAP) was overexpressed in various types of myelodysplastic syndromes and suppressed all three major hematopoietic lineages.
[Journal of Experimental Medicine] |
|
|
|
| Investigators described the identification of vimentin, an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Researchers isolated endothelial progenitor cells derived from the human kidney and surveyed microRNA target transcripts. They used a genetic knockout model to evaluate the effect of deleting endogenous expression of miR-218 specifically in angioblasts.
[Journal of the American Society of Nephrology] |
|
|
|
| Scientists investigated the effect of reduced complement factor H (FH) levels in the choroid to determine whether increasing local FH could protect choroidal endothelial cells from membrane attack complex deposition.
[Journal of Pathology] |
|
|
|
| In this in vitro study scientists assessed the cytotoxic effects of nickel oxide nanoparticles (NiONPs) on human pulmonary artery endothelial cells.
[Nanotoxicology] |
|
|
|
| Oxidized low-density lipoprotein was used to treat HUVECs to construct a cell injury model. The expression level of circCHMP5, miR-532-5p, and Rho-associated protein kinase 2 was measured using quantitative real-time PCR.
[Cardiovascular Drugs and Therapy] |
|
|
|
| Researchers used global gene expression in human coronary artery endothelial cells to identify gene pathways and cellular processes in response to chemical hypoxia, oxidized lipids, IL-1β induced inflammation, oscillatory flow, and these combined stimuli.
[Scientific Reports] |
|  |
|
|
|
| The authors examine endothelial cell bone morphogenetic protein (BMP) signaling in vitro and in vivo and discuss the paradox of BMP signals that both destabilize and stabilize endothelial cell behaviors.
[Cellular and Molecular Life Sciences] |
|
|
|
|
| Idorsia Ltd and Idorsia Pharmaceuticals Japan announced that the Japanese Pharmaceuticals and Medical Devices Agency has approved PIVLAZâ„¢ 150mg, a selective endothelin A receptor antagonist, for the prevention of cerebral vasospasm, vasospasm-related cerebral infarction and cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.
[Idorsia Ltd. (GlobeNewswire, Inc.)] |
|
|
|
| ​The US FDA has approved the use of Genentech (Roche)’s Vabysmo for the treatment of wet age-related macular degeneration and diabetic macular edema.
[BioSpace, Inc.] |
|
|
|
|
| April 6 – 9, 2022
Heidelberg, Germany |
|
|
|
|
|
| Helmholtz Centre for Infection Research – Braunschweig, Germany |
|
|
|
| | University of Southern Denmark – Odense M, Denmark |
|
|
|
| | Columbia University – New York, New York, United States |
|
|
|
| Ksilink – Strasbourg, France |
|
|
|
| | Howard Hughes Medical Institute – Dallas, Texas, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
