| Vol. 7.06 – 28 February, 2022 |
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| Mouse models of atherosclerosis in endothelial cell-specific-Bach1 knockout mice were used to study the role of BTB and CNC homology 1 (BACH1) in the regulation of atherogenesis and the underlying mechanisms. [Circulation Research] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Together with information from genome-wide association studies for vascular disease traits, scientists tested the ability of 34,344 variants to perturb enhancer function in endothelial cells using the highly multiplexed STARR-seq assay. [Genome Research] |
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| Glutathione peroxidase 2 (GPx2) loss stimulated malignant progression due to reactive oxygen species/hypoxia inducible factor-α (HIF1α)/VEGFA signaling, causing poor perfusion and hypoxia, which were reversed by GPx2 reexpression or HIF1α inhibition. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists reported that high-level mitochondrial respiration and constitutive low-level glycolysis supported liver sinusoidal endothelial cells scavenger and sentinel functions. [Cell Reports] |
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| Researchers hypothesized that endothelial glycocalyx damage in the coronary microcirculation contributed to increased microvascular permeability and hence to cardiac dysfunction. [Diabetologia] |
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| The authors’ findings supported a direct role for SARS-CoV-2 in mediating endothelial inflammation in an ACE2-dependent or -independent manner. [Stem Cell Reports] |
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| Investigators suggested that scutellarin reduced triple-negative breast cancer metastasis by suppressing tumor necrosis factor-α (TNFα)-initiated vascular endothelial barrier breakdown. [Acta Pharmacologica Sinica] |
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| The authors investigated the effects of trimetazidine on myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice. [Acta Pharmacologica Sinica] |
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| Researchers determined the effect and potential mechanism of heparanase on glomerular endothelial cells phenotype under high-glucose conditions. [Cell Death Discovery] |
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| In a co-culture system of HUVECs and acute lymphoblastic leukemia (ALL) cells, serine protease inhibitor Kazal type 1 (SPINK1) exposure resulted in enhanced endothelial cell motility and ALL cells trans-endothelial migration. [Scientific Reports] |
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| The effects of the ferroptosis inhibitor ferrostatin-1 on endothelial cell ferroptosis and pulmonary vascular remodelling in monocrotaline-induced rats were studied in vitro and in vivo. [Scientific Reports] |
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| Researchers investigated the effects of miR-29b-3p on the inflammation injury of HUVECs induced by lipopolysaccharide and explored the underlying mechanisms. [Biochemical Genetics] |
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| Scientists summarize recent advances in our understanding of the molecular mechanisms and clinical findings that impact the management of VEGFR inhibitor-induced hypertension. [Current Oncology Reports] |
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| The authors evaluate the relationship between VEGF and the prognosis of intrahepatic cholangiocarcinoma by meta-analysis. [World Journal of Surgical Oncology] |
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| Alkem Laboratories Limited has signed a license agreement with Harvard University’s Office of Technology Development enabling Alkem to develop and commercialize a novel technology that may help meet the dire need for effective treatment of diabetic neuropathy, foot ulcers, and peripheral arterial disease. [Alkem Laboratories Limited] |
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| Samsara Vision announced the first three successful clinical cases in Italy using its SING IMTâ„¢ (Smaller-Incision New-Generation Implantable Miniature Telescope) for people living with late-stage, age-related macular degeneration. [Samsara Vision (Businesswire, Inc.)] |
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| April 8 – 13, 2022 New Orleans, Louisiana, United States |
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| University of Lausanne – Lausanne, Switzerland |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| Yale University – New Haven, Connecticut, United States |
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| Columbia University – New York, New York, United States |
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| Ksilink – Strasbourg, France |
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