Endothelial Cell News Volume 7.06 | Feb 28 2022

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    2022-02-28 | ENDOCN 7.06


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.06 – 28 February, 2022
    TOP STORY

    Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation

    Mouse models of atherosclerosis in endothelial cell-specific-Bach1 knockout mice were used to study the role of BTB and CNC homology 1 (BACH1) in the regulation of atherogenesis and the underlying mechanisms.
    [Circulation Research]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Functional Noncoding SNPs in Human Endothelial Cells Fine-Map Vascular Trait Associations

    Together with information from genome-wide association studies for vascular disease traits, scientists tested the ability of 34,344 variants to perturb enhancer function in endothelial cells using the highly multiplexed STARR-seq assay.
    [Genome Research]

    Abstract

    Redox Signaling by Glutathione Peroxidase 2 Links Vascular Modulation to Metabolic Plasticity of Breast Cancer

    Glutathione peroxidase 2 (GPx2) loss stimulated malignant progression due to reactive oxygen species/hypoxia inducible factor-α (HIF1α)/VEGFA signaling, causing poor perfusion and hypoxia, which were reversed by GPx2 reexpression or HIF1α inhibition.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    IL-6-Induced FOXO1 Activity Determines the Dynamics of Metabolism in CD8 T Cells Cross-Primed by Liver Sinusoidal Endothelial Cells

    Scientists reported that high-level mitochondrial respiration and constitutive low-level glycolysis supported liver sinusoidal endothelial cells scavenger and sentinel functions.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Endothelial Glycocalyx Is Damaged in Diabetic Cardiomyopathy: Angiopoietin 1 Restores Glycocalyx and Improves Diastolic Function in Mice

    Researchers hypothesized that endothelial glycocalyx damage in the coronary microcirculation contributed to increased microvascular permeability and hence to cardiac dysfunction.
    [Diabetologia]

    Full ArticleGraphical Abstract

    A Human Pluripotent Stem Cell-Based Model of SARS-CoV-2 Infection Reveals an ACE2-Independent Inflammatory Activation of Vascular Endothelial Cells through TLR4

    The authors’ findings supported a direct role for SARS-CoV-2 in mediating endothelial inflammation in an ACE2-dependent or -independent manner.
    [Stem Cell Reports]

    Full Article

    Scutellarin Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting TNFα-Induced Vascular Endothelial Barrier Breakdown

    Investigators suggested that scutellarin reduced triple-negative breast cancer metastasis by suppressing tumor necrosis factor-α (TNFα)-initiated vascular endothelial barrier breakdown.
    [Acta Pharmacologica Sinica]

    Abstract

    Trimetazidine Enhances Myocardial Angiogenesis in Pressure Overload-Induced Cardiac Hypertrophy Mice through Directly Activating Akt and Promoting the Binding of HSF1 to VEGF-A Promoter

    The authors investigated the effects of trimetazidine on myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice.
    [Acta Pharmacologica Sinica]

    Full Article

    Heparanase Promotes Endothelial-to-Mesenchymal Transition in Diabetic Glomerular Endothelial Cells through Mediating ERK Signaling

    Researchers determined the effect and potential mechanism of heparanase on glomerular endothelial cells phenotype under high-glucose conditions.
    [Cell Death Discovery]

    Full Article

    Raised SPINK1 Levels Play a Role in Angiogenesis and the Transendothelial Migration of ALL Cells

    In a co-culture system of HUVECs and acute lymphoblastic leukemia (ALL) cells, serine protease inhibitor Kazal type 1 (SPINK1) exposure resulted in enhanced endothelial cell motility and ALL cells trans-endothelial migration.
    [Scientific Reports]

    Full Article

    Endothelial Cell Ferroptosis Mediates Monocrotaline-Induced Pulmonary Hypertension in Rats by Modulating NLRP3 Inflammasome Activation

    The effects of the ferroptosis inhibitor ferrostatin-1 on endothelial cell ferroptosis and pulmonary vascular remodelling in monocrotaline-induced rats were studied in vitro and in vivo.
    [Scientific Reports]

    Full Article

    MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A

    Researchers investigated the effects of miR-29b-3p on the inflammation injury of HUVECs induced by lipopolysaccharide and explored the underlying mechanisms.
    [Biochemical Genetics]

    Abstract
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    REVIEWS

    VEGF Receptor Inhibitor-Induced Hypertension: Emerging Mechanisms and Clinical Implications

    Scientists summarize recent advances in our understanding of the molecular mechanisms and clinical findings that impact the management of VEGFR inhibitor-induced hypertension.
    [Current Oncology Reports]

    Abstract

    The VEGF Expression Associated with Prognosis in Patients with Intrahepatic Cholangiocarcinoma: A Systematic Review and Meta-Analysis

    The authors evaluate the relationship between VEGF and the prognosis of intrahepatic cholangiocarcinoma by meta-analysis.
    [World Journal of Surgical Oncology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Alkem Licenses Technology from Harvard University, Aiming to Treat Ischemic Injury and Vascular Diseases

    Alkem Laboratories Limited has signed a license agreement with Harvard University’s Office of Technology Development enabling Alkem to develop and commercialize a novel technology that may help meet the dire need for effective treatment of diabetic neuropathy, foot ulcers, and peripheral arterial disease.
    [Alkem Laboratories Limited]

    Press Release

    Italian Patients Receive Samsara Vision’s SING IMT™, a New Technology for Age-Related Macular Degeneration

    Samsara Vision announced the first three successful clinical cases in Italy using its SING IMTâ„¢ (Smaller-Incision New-Generation Implantable Miniature Telescope) for people living with late-stage, age-related macular degeneration.
    [Samsara Vision (Businesswire, Inc.)]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2022

    April 8 – 13, 2022
    New Orleans, Louisiana, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Tissue Engineering and Epigenetics

    University of Lausanne – Lausanne, Switzerland

    Postdoctoral Position – Cardiovascular Physiology

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Postdoctoral Scientist – Tissue Engineering, and Stem Cell Biology

    Yale University – New Haven, Connecticut, United States

    Postdoctoral Positions – Atherosclerosis

    Columbia University – New York, New York, United States

    Research Scientist – Cardiobiology

    Ksilink – Strasbourg, France

    > See All Jobs

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