| Vol. 7.07 – 7 March, 2022 |
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| Researchers performed multiplex ELISA angiogenesis arrays on aqueous fluid from proliferative diabetic retinopathy patients who responded inadequately to anti-VEGF therapy and/or pan-retinal laser photocoagulation and identified plasminogen activator inhibitor-1 (PAI-1). [Science Advances] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that the endothelial Unc5B receptor controlled blood-brain barrier integrity by maintaining Wnt/β-catenin signaling. [Nature Communications] |
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| The authors found that TLR4 signaling in vascular endothelial cells and downstream NADPH oxidase 4 expression mediated the arrest of neutrophils, a step upstream of their extravasation. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators found endothelial DKK1 expression was upregulated in serum and lung tissues obtained from patients with pulmonary hypertension (PH), mice with hypoxia-induced PH, and human pulmonary artery endothelial cells cultured under hypoxic conditions. [Hypertension] |
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| RNA sequencing of cisplatin-resistant and -sensitive ovarian cancer organoids was performed, followed by detection of the expression level of fibrillin-1 in organoids and clinical specimens of ovarian cancer. [Cancer Communications] |
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| Rat bone marrow derived mesenchymal stem cells (MSCs) and HUVECs were co-cultured onto scaffolds fabricated by the authors to enhance vascularization for bone tissue regeneration. [Colloids and Surfaces B-Biointerfaces] |
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| Investigators unveiled a novel DNA methyltransferase 1-SIRT6 axis that contributed to the regulation of myocardin-related transcription factor A (MRTF-A) acetylation and ICAM-1 transactivation in endothelial cells. [Cell Death Discovery] |
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| The authors investigated if ghrelin pretreatment enhanced the protective effect of bone marrow-derived mesenchymal stem cells-conditioned medium on lipopolysaccharide-induced endothelial cell injury. [Molecular and Cellular Endocrinology] |
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| Shuxuetong injection promoted angiogenesis and improved function recovery in hindlimb ischemia mice by regulation of VEGF-A/platelet-derived growth factor. [Journal of Ethnopharmacology] |
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| Scientists found that in oxidized low-density lipoprotein-treated HUVECs, the increased production of total cholesterol, free cholesterol, and pro-inflammatory cytokines were observed, reversed by 10 μM and 25 μM Nintedanib. [Bioengineered] |
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| The authors summarize recent evidence that modulation of the early secretory pathway has great impact on the biogenesis and release of Weibel-Palade bodies. [FEBS Journal] |
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| Scientists consider in-depth mechanisms of endothelial activation and the novel mechanism of endothelial antigen presentation. [American Journal of Physiology-Renal Physiology] |
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| Elpiscience Biopharmaceuticals, Inc. announced that the first patient has been dosed in a Phase I/II clinical study, evaluating the safety, tolerability, preliminary anti-tumor efficacy and pharmacokinetics of ES104, a bispecific antibody that simultaneously blocks the DLL4 and VEGF-A signaling pathways. [Elpiscience Biopharmaceuticals, Inc.] |
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| HUTCHMED Limited announced that it has received approval to market ELUNATE®, a selective and potent oral inhibitor of VEGFR 1, 2 and 3, in the Macau Special Administrative Region. [HUTCHMED Limited] |
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| Johns Hopkins School of Medicine – Saint Petersburg, Florida, United States |
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| University of Lausanne – Lausanne, Switzerland |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| Yale University – New Haven, Connecticut, United States |
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| Columbia University – New York, New York, United States |
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