Endothelial Cell News Volume 7.07 | Mar 7 2022

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    2022-03-07 | ENDOCN 7.07


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.07 – 7 March, 2022
    TOP STORY

    PAI-1 Is a Vascular Cell–Specific HIF-2–Dependent Angiogenic Factor That Promotes Retinal Neovascularization in Diabetic Patients

    Researchers performed multiplex ELISA angiogenesis arrays on aqueous fluid from proliferative diabetic retinopathy patients who responded inadequately to anti-VEGF therapy and/or pan-retinal laser photocoagulation and identified plasminogen activator inhibitor-1 (PAI-1).
    [Science Advances]

    Full Article
    Explore tools and resources for your return to the lab
    PUBLICATIONSRanked by the impact factor of the journal

    Endothelial Unc5B Controls Blood-Brain Barrier Integrity

    Scientists showed that the endothelial Unc5B receptor controlled blood-brain barrier integrity by maintaining Wnt/β-catenin signaling.
    [Nature Communications]

    Full Article

    Necroptosis Triggers Spatially Restricted Neutrophil-Mediated Vascular Damage during Lung Ischemia Reperfusion Injury

    The authors found that TLR4 signaling in vascular endothelial cells and downstream NADPH oxidase 4 expression mediated the arrest of neutrophils, a step upstream of their extravasation.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Upregulation of Endothelial DKK1 (Dickkopf 1) Promotes the Development of Pulmonary Hypertension through the Sp1 (Specificity Protein 1)/SHMT2 (Serine Hydroxymethyltransferase 2) Pathway

    Investigators found endothelial DKK1 expression was upregulated in serum and lung tissues obtained from patients with pulmonary hypertension (PH), mice with hypoxia-induced PH, and human pulmonary artery endothelial cells cultured under hypoxic conditions.
    [Hypertension]

    Abstract

    The Fibrillin-1/VEGFR2/STAT2 Signaling Axis Promotes Chemoresistance via Modulating Glycolysis and Angiogenesis in Ovarian Cancer Organoids and Cells

    RNA sequencing of cisplatin-resistant and -sensitive ovarian cancer organoids was performed, followed by detection of the expression level of fibrillin-1 in organoids and clinical specimens of ovarian cancer.
    [Cancer Communications]

    Full Article

    Hydrostatic Pressure Stimulates the Osteogenesis and Angiogenesis of MSCs/HUVECs Co-Culture on Porous PLGA Scaffolds

    Rat bone marrow derived mesenchymal stem cells (MSCs) and HUVECs were co-cultured onto scaffolds fabricated by the authors to enhance vascularization for bone tissue regeneration.
    [Colloids and Surfaces B-Biointerfaces]

    AbstractGraphical Abstract

    SIRT6 Mediates MRTF-A Deacetylation in Vascular Endothelial Cells to Antagonize oxLDL-Induced ICAM-1 Transcription

    Investigators unveiled a novel DNA methyltransferase 1-SIRT6 axis that contributed to the regulation of myocardin-related transcription factor A (MRTF-A) acetylation and ICAM-1 transactivation in endothelial cells.
    [Cell Death Discovery]

    Full Article

    Ghrelin Pretreatment Enhanced the Protective Effect of Bone Marrow-Derived Mesenchymal Stem Cell-Conditioned Medium on Lipopolysaccharide-Induced Endothelial Cell Injury

    The authors investigated if ghrelin pretreatment enhanced the protective effect of bone marrow-derived mesenchymal stem cells-conditioned medium on lipopolysaccharide-induced endothelial cell injury.
    [Molecular and Cellular Endocrinology]

    Abstract

    Shuxuetong Injection and Its Peptides Enhance Angiogenesis after Hindlimb Ischemia by Activating the MYPT1/LIMK1/Cofilin Pathway

    Shuxuetong injection promoted angiogenesis and improved function recovery in hindlimb ischemia mice by regulation of VEGF-A/platelet-derived growth factor.
    [Journal of Ethnopharmacology]

    AbstractGraphical Abstract

    Nintedanib Ameliorates Oxidized Low-Density Lipoprotein-Induced Inflammation and Cellular Senescence in Vascular Endothelial Cells

    Scientists found that in oxidized low-density lipoprotein-treated HUVECs, the increased production of total cholesterol, free cholesterol, and pro-inflammatory cytokines were observed, reversed by 10 μM and 25 μM Nintedanib.
    [Bioengineered]

    Full ArticleGraphical Abstract
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    REVIEWS

    Dispatch and Delivery at the ER – Golgi Interface: How Endothelial Cells Tune Their Hemostatic Response

    The authors summarize recent evidence that modulation of the early secretory pathway has great impact on the biogenesis and release of Weibel-Palade bodies.
    [FEBS Journal]

    AbstractFull Article

    Endothelial Cells: Potential Novel Regulators of Renal Inflammation

    Scientists consider in-depth mechanisms of endothelial activation and the novel mechanism of endothelial antigen presentation.
    [American Journal of Physiology-Renal Physiology]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Elpiscience Announces First Patient Dosed in Phase I/II Clinical Study of ES104 for Treatment of Colorectal Cancer

    Elpiscience Biopharmaceuticals, Inc. announced that the first patient has been dosed in a Phase I/II clinical study, evaluating the safety, tolerability, preliminary anti-tumor efficacy and pharmacokinetics of ES104, a bispecific antibody that simultaneously blocks the DLL4 and VEGF-A signaling pathways.
    [Elpiscience Biopharmaceuticals, Inc.]

    Press Release

    HUTCHMED Receives Approval to Commercialize ELUNATE® in Macau

    HUTCHMED Limited announced that it has received approval to market ELUNATE®, a selective and potent oral inhibitor of VEGFR 1, 2 and 3, in the Macau Special Administrative Region.
    [HUTCHMED Limited]

    Press Release
    FEATURED EVENT

    13th Online Dutch Stem Cell Meeting

    April 16, 2022
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Vascular Biology

    Johns Hopkins School of Medicine – Saint Petersburg, Florida, United States

    Postdoctoral Position – Tissue Engineering and Epigenetics

    University of Lausanne – Lausanne, Switzerland

    Postdoctoral Position – Cardiovascular Physiology

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Postdoctoral Scientist – Tissue Engineering, and Stem Cell Biology

    Yale University – New Haven, Connecticut, United States

    Postdoctoral Positions – Atherosclerosis

    Columbia University – New York, New York, United States

    > See All Jobs

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