 | | Vol. 7.10 – 28 March, 2022 |
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| Investigators developed in vitro methods using a kidney decellularized extracellular matrix hydrogel to culture human pluripotent stem cell-derived kidney organoids, which had extensive vascular network and their own endothelial cells.
[Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| LCL/ZnO could selectively regulate tumor-derived endothelial cells (TECs) and specifically kill tumor cells, by responding to different H2O2 gradients in TECs and tumor cells.
[Small] |
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| The authors established the relevance of interclonal cross-talk between MYC-driven and non-MYC-driven medulloblastoma cells.
[Neuro-Oncology] |
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| Scientists found that exosomes from primary brain tumors could upregulate the expression of lipocalin-2 in bEnd.3 brain microvascular endothelial cells.
[Journal of Controlled Release] |
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| Researchers investigated the therapeutic potential of bevacizumab in angiogenesis during osteosarcoma and the related mechanisms.
[Cell Death & Disease] |
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| Engineered microvessels were lined with human endothelial cells, cultured under flow, and activated to release Von Willebrand factor (VWF) and formed transluminal VWF fibers.
[Journal of Thrombosis and Haemostasis] |
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| Researchers examined the role of interleukin-6 (IL-6) in defective angiogenesis mediated by leucine-rich α-2-glycoprotein 1 (LRG1). IL-6 treatment induced LRG1 expression in endothelial cells and ex vivo angiogenesis cultures and promoted vascular growth with reduced mural cell coverage.
[Scientific Reports] |
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| Enforced expression of Lyve1 in RAW264.7 cells resulted in increased mRNA expression of matrix metalloproteinase 2 (Mmp2), Mmp9, and VEGF A. Lyve1-expressing macrophages promoted the migration and tube formation of HUVECs.
[Scientific Reports] |
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| Investigators analyzed the carcinogenetic potential of exposure to GHRH of a nontumor human prostate epithelial cell line (RWPE-1) as well as its transforming effect in a xenograft model.
[Prostate] |
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| Scientists provide a comprehensive overview of how hyperglycemia in type 2 diabetes reprograms endothelial epigenome and lead to functional consequences in the pathogenesis of vascular complications.
[Life Sciences] |
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| The authors comprehensively review the role of high-mobility group box 1 (HMGB1), hypoxia-inducible factor-1α (HIF-1α), and VEGF in doxorubicin-induced cardiovascular disease and its molecular mechanisms.
[Annals of Medicine] |
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| Under a CRADA, the National Eye Institute and Curative Biotechnology, Inc. will collaborate to evaluate Curative’s proprietary ocular metformin formulation in clinical studies for the treatment of intermediate and late-stage age-related macular degeneration disease.
[Curative Biotechnology, Inc.] |
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| RIBOMIC, Inc. announced the results from the investigator sponsored trial , TEMPURA, along with updated data from its TOFU and RAMEN studies with RBM-007, an investigational anti-fibroblast growth factor-2 aptamer, in wet age-related macular degeneration.
[RIBOMIC, Inc.] |
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| May 12 – 14, 2022
San Francisco, California, United States
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Thorax Institute – Nantes, France |
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| Babraham Institute – Cambridgeshire, England, United Kingdom |
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| | Johns Hopkins School of Medicine – Saint Petersburg, Florida, United States |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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