Endothelial Cell News Volume 7.12 | Apr 11 2022

May 12, 2022

2022-04-11 | ENDOCN 7.12

Endothelial Cell News by STEMCELL Technologies

Vol. 7.12 – 11 April, 2022

TOP STORY

Specification of Fetal Liver Endothelial Progenitors to Functional Zonated Adult Sinusoids Requires C-Maf Induction

Scientists studied the heterogeneity of hepatic vascular cells during mouse development through functional and single-cell RNA-sequencing.
[Cell Stem Cell]

Abstract Graphical Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries

Electrophysiological analyses confirmed expression and function of Piezo1 channels in brain cortical and retinal capillaries. Activation of Piezo1 channels evoked currents that were sensitive to endothelial cell–specific Piezo1 deletion.
[Circulation Research]

Abstract Graphical Abstract

Astrocyte Plasticity in Mice Ensures Continued Endfoot Coverage of Cerebral Blood Vessels Following Injury and Declines with Age

The authors investigated if focal ablation of astrocytes was sufficient to disrupt the blood-brain barrier in mice. Targeted two-photon chemical apoptotic ablation of astrocytes induced a plasticity response whereby surrounding astrocytes extended processes to cover vascular vacancies.
[Nature Communications]

Full Article

Therapeutic Correction of Hemophilia A by Transplantation of hPSC-Derived Liver Sinusoidal Endothelial Cell Progenitors

Researchers developed an efficient and scalable protocol to produce human pluripotent stem cell (hPSC)-derived liver sinusoidal endothelial cells progenitors characterized as venous endothelial cells from different mesoderm subpopulations.
[Cell Reports]

Full Article Graphical Abstract

Rapid Shear Stress-Dependent ENaC Membrane Insertion Is Mediated by the Endothelial Glycocalyx and the Mineralocorticoid Receptor

Endothelial epithelial Na⁺ channel (ENaC), together with the glycocalyx, was identified as an important shear stress sensor and mediator of endothelium-dependent vasodilation.
[Cellular and Molecular Life Sciences]

Full Article

MicroRNA-22 Coordinates Vascular and Motor Neuronal Pathfinding via sema4 during Zebrafish Development

Scientists showed that the deficiency of miRNA-22a, an endothelial-enriched miRNA, caused dramatic pathfinding defects both in intersegmental vessels and primary motor neurons in zebrafish embryos.
[Open Biology]

Full Article

Exosomal HMGA2 Protein from EBV-Positive NPC Cells Destroys Vascular Endothelial Barriers and Induces Endothelial-to-Mesenchymal Transition to Promote Metastasis

Investigators showed that exosomes from Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) cells, but not exosomes from EBV-negative NPC cells, destroyed endothelial cell tight junction proteins and promoted endothelial-to-mesenchymal transition in endothelial cells.
[Cancer Gene Therapy]

Full Article

Single-Cell Transcriptome Analysis Reveals Aberrant Stromal Cells and Heterogeneous Endothelial Cells in Alcohol-Induced Osteonecrosis of the Femoral Head

The authors used single-cell RNA sequencing to explore the transcriptomic landscape of mid- and advanced-stage alcohol-induced osteonecrosis of the femoral head.
[Communications Biology]

Full Article

High miR203a-3p and miR-375 Expression in the Airways of Smokers with and without COPD

Researchers elucidated the overall smoking-induced miRNA changes and those specific to chronic obstructive pulmonary disease (COPD).They investigated the downstream effects on regulatory gene expression and the correlation to cellular composition.
[Scientific Reports]

Full Article

Identification of Lamprey Variable Lymphocyte Receptors That Target the Brain Vasculature

Investigators describe an innovative screening platform for the identification of new blood-brain barrier targeting molecules from a class of lamprey antigen-recognition proteins known as variable lymphocyte receptors.
[Scientific Reports]

Full Article

Small Conductance Calcium-Activated Potassium Channels and Nitric Oxide/cGMP Pathway Mediate Cardioprotective Effects of Croton urucurana Baill. In Hypertensive Rats

Researchers investigated the cardiovascular effects of the Croton urucurana extract in spontaneously hypertensive rats.
[Journal of Ethnopharmacology]

Abstract Graphical Abstract

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REVIEWS

Endothelial Function and Endothelial Progenitor Cells in Systemic Lupus Erythematosus

Scientists discuss factors that contribute to cardiovascular disease in systemic lupus erythematosus (SLE), with particular focus on how endothelial function and endothelial progenitor cells (EPCs) are evaluated currently, and how EPCs are quantitatively and functionally altered in patients with SLE.
[Nature Reviews Rheumatology]

Abstract

INDUSTRY AND POLICY NEWS

PEI Regulatory Approval Received for Government Funded (€7.4 Million) Clinical Trial Investigating Adrenomed’s Adrecizumab in Treating Endothelial Barrier Dysfunction in Hospitalized COVID-19 Patients

Adrenomed AG announced that its proprietary sepsis drug candidate Adrecizumab received a funding commitment of €7.4 million from the German Federal Ministry of Education and Research as part of the German funding initiatives for the clinical development of COVID-19 drugs.
[Adrenomed AG]

Press Release

Acer Therapeutics’ EDSIVO™ (celiprolol) Granted FDA Breakthrough Therapy Designation for Vascular Ehlers-Danlos Syndrome

Acer Therapeutics, Inc. announced the FDA has granted celiprolol breakthrough therapy designation in the US for the treatment of patients with COL3A1-positive vascular Ehlers-Danlos syndrome.
[Acer Therapeutics, Inc.]

Press Release

FEATURED EVENT

Specification of Fetal Liver Endothelial Progenitors to Functional Zonated Adult Sinusoids Requires C-Maf Induction

Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries

Astrocyte Plasticity in Mice Ensures Continued Endfoot Coverage of Cerebral Blood Vessels Following Injury and Declines with Age

Therapeutic Correction of Hemophilia A by Transplantation of hPSC-Derived Liver Sinusoidal Endothelial Cell Progenitors

Rapid Shear Stress-Dependent ENaC Membrane Insertion Is Mediated by the Endothelial Glycocalyx and the Mineralocorticoid Receptor

MicroRNA-22 Coordinates Vascular and Motor Neuronal Pathfinding via sema4 during Zebrafish Development

Exosomal HMGA2 Protein from EBV-Positive NPC Cells Destroys Vascular Endothelial Barriers and Induces Endothelial-to-Mesenchymal Transition to Promote Metastasis

Single-Cell Transcriptome Analysis Reveals Aberrant Stromal Cells and Heterogeneous Endothelial Cells in Alcohol-Induced Osteonecrosis of the Femoral Head

High miR203a-3p and miR-375 Expression in the Airways of Smokers with and without COPD

Identification of Lamprey Variable Lymphocyte Receptors That Target the Brain Vasculature

Small Conductance Calcium-Activated Potassium Channels and Nitric Oxide/cGMP Pathway Mediate Cardioprotective Effects of Croton urucurana Baill. In Hypertensive Rats

Endothelial Function and Endothelial Progenitor Cells in Systemic Lupus Erythematosus

PEI Regulatory Approval Received for Government Funded (€7.4 Million) Clinical Trial Investigating Adrenomed’s Adrecizumab in Treating Endothelial Barrier Dysfunction in Hospitalized COVID-19 Patients

Acer Therapeutics’ EDSIVO™ (celiprolol) Granted FDA Breakthrough Therapy Designation for Vascular Ehlers-Danlos Syndrome

Healthy Aging

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Postdoctoral Fellow – Vascular Biology

Postdoctoral Research Fellowship – Endothelial Basis of Cardiovascular and Metabolic Disease

Postdoctoral Researcher – Renal and Cardiovascular Animal Models

Research Lead – Discovery Research

Postdoctoral Position – Vascular Biology & Immunotherapy

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