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Colony Stimulating Factor-1 Producing Endothelial Cells and Mesenchymal Stromal Cells Maintain Monocytes within a Perivascular Bone Marrow Niche | Scientists showed that osteolineage-derived colony-stimulating factor-1 prevented developmental abnormalities but had no effect on monopoiesis in adulthood.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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TRIM47 Is a Novel Endothelial Activation Factor That Aggravates Lipopolysaccharide-Induced Acute Lung Injury in Mice via K63-Linked Ubiquitination of TRAF2 | The authors reported that tripartite motif-containing 47 (TRIM47), an E3 ubiquitin ligase of the tripartite motif-containing protein family, was highly expressed in vascular endothelial cells.
[Signal Transduction and Targeted Therapy] |
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Transmembrane Stem Cell Factor Protein Therapeutics Enhance Revascularization in Ischemia without Mast Cell Activation | Proteoliposomal transmembrane stem cell factor (tmSCF) preferentially acted on endothelial cells to induce angiogenesis while tmSCF nanodiscs had greater activity in inducing stem cell mobilization and recruitment to the site of injury.
[Nature Communications] |
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Small-World Connectivity Dictates Collective Endothelial Cell Signaling | Distributed sensing is difficult to reconcile across large regions of the endothelium. Investigators showed that the endothelium resolved distributed sensing by using a network with scale-free and small-world properties.
[Proceedings of the National Academy of Sciences of the United States of America] |
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The C5a-C5aR1 Complement Axis Is Essential for Neutrophil Recruitment to Draining Lymph Nodes via High Endothelial Venules in Cutaneous Leishmaniasis | Cell-tracking experiments, together with intravital two-photon microscopy, indicated that neutrophil recruitment to draining lymph nodes occurred minimally through lymphatics from the infected dermis, but mostly through blood vessels via high endothelial venules.
[Cell Reports] |
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Endothelial PRMT5 Plays a Crucial Role in Angiogenesis after Acute Ischemic Injury | Researchers investigated whether protein arginine methyltransferases 5 (PRMT5), a major type II enzyme, was involved in pathological angiogenesis and elucidated the molecular mechanism involved.
[JCI Insight] |
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Laminar Shear Stress Inhibits Inflammation by Activating Autophagy in Human Aortic Endothelial Cells through HMGB1 Nuclear Translocation | Scientists found that laminar shear stress could inhibit the increased expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, cyclooxygenase-2, and matrix metallopeptidase-9 caused by TNF-α in an autophagy-dependent pathway in human aortic endothelial cells and HUVECs.
[Communications Biology] |
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LncRNA LYPLAL1-DT Screening from Type 2 Diabetes with Macrovascular Complication Contributes Protective Effects on Human Umbilical Vein Endothelial Cells via Regulating the miR-204-5p/SIRT1 Axis | The authors identified LYPLAL1-DT as having had protective effects on endothelial cells as competing endogenous RNA mediated through the miR-204-5p/SIRT1 pathway.
[Cell Death Discovery] |
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The Transcription Factor Complex LMO2/TAL1 Regulates Branching and Endothelial Cell Migration in Sprouting Angiogenesis | Knockdown of LMO2 or TAL1 inhibited capillary sprouting in spheroid-based angiogenesis assays, which was associated with decreased angiopoietin 2 secretion.
[Scientific Reports] |
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Scutellaria barbata D.Don (SBD) Extracts Suppressed Tumor Growth, Metastasis and Angiogenesis in Prostate Cancer via PI3K/Akt Pathway | A 2RRV1 mouse xenograft model was established to detect the effect of SBD on prostate cancer (PCa). Angiogenesis was analyzed by coculturing PCa cell lines and HUVECs.
[BMC Complementary and Alternative Medicine] |
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Effect of Angiogenesis in Bone Tissue Engineering | Investigators discuss promising advances of angiogenesis in bone tissue engineering by scaffold designs, angiogenic factor delivery, in vivo prevascularization, and in vitro prevascularization.
[Annals of Biomedical Engineering] |
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Advances in the Pharmacological Intervention of Endothelial Progenitor Cells in the Treatment of Ischemic Stroke | Scientists focus on the mechanism of endothelial progenitor cells (EPCs) in the treatment of ischemic stroke and the intervention of various novel drugs, including small molecules and biomolecules, which will promote the capture, proliferation, and differentiation of EPCs.
[Cerebrovascular Diseases] |
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Compass Therapeutics Reports Positive Interim Phase II Data of CTX-009 in Combination with Paclitaxel in Biliary Tract Cancers | Compass Therapeutics, Inc. reported additional interim results from a Phase II study of CTX-009, a bispecific antibody that simultaneously blocks Delta-like ligand 4/Notch and VEGF-A signaling pathways, in combination with paclitaxel in patients with biliary tract cancers.
[Compass Therapeutics, Inc.] |
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| June 15 – 18, 2022
San Francisco, California, United States |
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| | Flanders Institute for Biotechnology – Leuven, Belgium |
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| Johns Hopkins University School of Medicine – St. Petersburg, Florida, United States |
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| | New York University College of Dentistry – New York, New York, United States |
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| University of Lausanne – Lausanne, Switzerland |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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