Endothelial Cell News Volume 7.17 | May 16 2022

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    2022-05-16 | ENDOCN 7.17


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.17 – 16 May, 2022
    TOP STORY

    ETV2 Functions as a Pioneer Factor to Regulate and Reprogram the Endothelial Lineage

    Scientists reported that ETV2 functioned as a pioneer factor that relaxed closed chromatin and regulated endothelial development.
    [Nature Cell Biology]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Mechanical Loading of Intraluminal Pressure Mediates Wound Angiogenesis by Regulating the TOCA Family of F-BAR Proteins

    Investigators demonstrated a crucial role of blood flow-driven intraluminal pressure in regulating wound angiogenesis.
    [Nature Communications]

    Full Article

    Aspartate Metabolism in Endothelial Cells Activates the mTORC1 Pathway to Initiate Translation during Angiogenesis

    The authors showed in both human cell lines and mouse models that during developmental and pathological angiogenesis, endothelial cells used glutaminolysis-derived glutamate to produce aspartate via aspartate aminotransferase.
    [Developmental Cell]

    AbstractGraphical Abstract

    Intrinsic Epigenetic Control of Angiogenesis in Induced Pluripotent Stem Cell-Derived Endothelium Regulates Vascular Regeneration

    Researchers determined the angiogenic phenotype of induced pluripotent stem cell-derived endothelial cells and the regulatory mechanism controlling their regenerative capacity.
    [NPJ Regenerative Medicine]

    Full Article

    Endothelial ETS1 Inhibition Exacerbate Blood–Brain Barrier Dysfunction in Multiple Sclerosis through Inducing Endothelial-to-Mesenchymal Transition

    Investigators demonstrated that endothelial-to-mesenchymal transition accompanied the blood–brain barrier dysfunction in several neurological disorders, especially in multiple sclerosis.
    [Cell Death & Disease]

    Full Article

    Latrophilin-2 Is a Novel Receptor of LRG1 That Rescues Vascular and Neurological Abnormalities and Restores Diabetic Erectile Function

    The authors found that the adhesion GPCR latrophilin-2 (LPHN2) was a TGF-β-independent receptor of leucine-rich ɑ-2-glycoprotein 1 (LRG1). By interacting with LPHN2, LRG1 promoted both angiogenic and neurotrophic processes in mouse tissue explants under hyperglycemic conditions.
    [Experimental & Molecular Medicine]

    Full Article

    Yeast Beta-Glucan Mediates Histone Deacetylase 5-Induced Angiogenesis in Vascular Endothelial Cells

    Scientists investigated the correlation between β-glucan and histone deacetylase 5 (HDAC5) in HUVECs, revealing the role of β-glucan in angiogenesis, and confirmed that HDAC5 was phosphorylated by β-glucan stimulation and released from the nucleus to the cytoplasm.
    [International Journal of Biological Macromolecules]

    Abstract

    Immortalized Human Choroid Plexus Endothelial Cells Enable an Advanced Endothelial-Epithelial Two-Cell Type In Vitro Model of the Choroid Plexus

    Transduction of primary human choroid plexus endothelial cells (HCPEnC) with the human telomerase reverse transcriptase resulted in immortalized HCPEnC, which grew as monolayer with contact inhibition, formed capillary-like tubes in Matrigel, and showed no colony growth in soft agar.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Sotatercept Analog Suppresses Inflammation to Reverse Experimental Pulmonary Arterial Hypertension

    Researchers determined through genome-wide expression profiling that inflammatory and immune responses were prominently upregulated in the lungs of a Sugen-hypoxia rat model of severe angio-obliterative pulmonary arterial hypertension (PAH), concordant with profiles observed in PAH patients.
    [Scientific Reports]

    Full Article

    Pro-Angiogenic Role of ZEB1 in Skin Wound Healing by Upregulating VEGFA via microRNA-206 Suppression

    Cell and animal experiments were implemented to figure out whether zinc finger E-box binding homeobox 1 (ZEB1) orchestrated angiogenesis during skin wound healing.
    [Experimental Dermatology]

    Abstract

    Apelin-Driven Endothelial Cell Migration Sustains Intestinal Progenitor Cells and Tumor Growth

    The authors reported that in colorectal cancer, expansion of the stem/progenitor pool in intestinal crypts required VEGFA-independent growth and remodeling of blood vessels.
    [Nature Cardiovascular Research]

    Abstract

    Syndecan-2 Selectively Regulates VEGF-Induced Vascular Permeability

    Researchers reported that a proteoglycan, Syndecan-2, regulated the interaction between a transmembrane phosphatase, DEP1, and VEGFR2 by controlling cell surface levels of DEP1.
    [Nature Cardiovascular Research]

    Abstract

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    REVIEWS

    Organ-Specific Endothelial Cell Heterogenicity and Its Impact on Regenerative Medicine and Biomedical Engineering Applications

    The authors highlight the main differences between different endothelial cell (EC) types, briefly summarize their different characteristics, and focus on the use of ECs in in vitro models.
    [Advanced Drug Delivery Reviews]

    Full ArticleGraphical Abstract

    New Insight into Dyslipidemia-Induced Cellular Senescence in Atherosclerosis

    Scientists summarize the current evidence for dyslipidemia-induced cellular senescence during atherosclerosis, with a focus on low-density lipoprotein and its modifications, hydrolysate of triglyceride-rich lipoproteins, and high-density lipoprotein.
    [Biological Reviews]

    Full Article

    INDUSTRY AND POLICY NEWS

    Oxurion Announces Top-Line Results from Part A of Phase II INTEGRAL Trial Evaluating THR-687 for Treatment of Diabetic Macular Edema (DME)

    Oxurion NV announced top-line results from Part A of its Phase II trial of THR-687, an integrin antagonist, for the treatment of DME.
    [Oxurion NV]

    Press Release

    FEATURED EVENT

    Endothelial Cell Phenotypes in Health and Disease

    June 26 – July 1, 2022
    Castelldefels, Spain

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    JOB OPPORTUNITIES

    Principal Investigator – Interdisciplinary Research in Biology

    CNRS – Paris, France

    Staff Scientist – Angiogenesis and Vascular Metabolism

    Flanders Institute for Biotechnology (VIB) – Leuven, Belgium

    Postdoctoral Fellow – Immuno-Oncology/Vascular Biology Research

    Johns Hopkins University School of Medicine – St. Petersburg, Florida, United States

    Tenure Track Faculty Position – Cell Signaling

    New York University College of Dentistry – New York, New York, United States

    Postdoctoral Fellowship – Microvasculature of Organs

    University of Lausanne – Lausanne, Switzerland

    > See All Jobs

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