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ETV2 Functions as a Pioneer Factor to Regulate and Reprogram the Endothelial Lineage | Scientists reported that ETV2 functioned as a pioneer factor that relaxed closed chromatin and regulated endothelial development. [Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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Mechanical Loading of Intraluminal Pressure Mediates Wound Angiogenesis by Regulating the TOCA Family of F-BAR Proteins | Investigators demonstrated a crucial role of blood flow-driven intraluminal pressure in regulating wound angiogenesis. [Nature Communications] |
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Aspartate Metabolism in Endothelial Cells Activates the mTORC1 Pathway to Initiate Translation during Angiogenesis | The authors showed in both human cell lines and mouse models that during developmental and pathological angiogenesis, endothelial cells used glutaminolysis-derived glutamate to produce aspartate via aspartate aminotransferase. [Developmental Cell] |
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Intrinsic Epigenetic Control of Angiogenesis in Induced Pluripotent Stem Cell-Derived Endothelium Regulates Vascular Regeneration | Researchers determined the angiogenic phenotype of induced pluripotent stem cell-derived endothelial cells and the regulatory mechanism controlling their regenerative capacity. [NPJ Regenerative Medicine] |
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Endothelial ETS1 Inhibition Exacerbate Blood–Brain Barrier Dysfunction in Multiple Sclerosis through Inducing Endothelial-to-Mesenchymal Transition | Investigators demonstrated that endothelial-to-mesenchymal transition accompanied the blood–brain barrier dysfunction in several neurological disorders, especially in multiple sclerosis. [Cell Death & Disease] |
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Latrophilin-2 Is a Novel Receptor of LRG1 That Rescues Vascular and Neurological Abnormalities and Restores Diabetic Erectile Function | The authors found that the adhesion GPCR latrophilin-2 (LPHN2) was a TGF-β-independent receptor of leucine-rich ɑ-2-glycoprotein 1 (LRG1). By interacting with LPHN2, LRG1 promoted both angiogenic and neurotrophic processes in mouse tissue explants under hyperglycemic conditions. [Experimental & Molecular Medicine] |
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Yeast Beta-Glucan Mediates Histone Deacetylase 5-Induced Angiogenesis in Vascular Endothelial Cells | Scientists investigated the correlation between β-glucan and histone deacetylase 5 (HDAC5) in HUVECs, revealing the role of β-glucan in angiogenesis, and confirmed that HDAC5 was phosphorylated by β-glucan stimulation and released from the nucleus to the cytoplasm. [International Journal of Biological Macromolecules] |
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Immortalized Human Choroid Plexus Endothelial Cells Enable an Advanced Endothelial-Epithelial Two-Cell Type In Vitro Model of the Choroid Plexus | Transduction of primary human choroid plexus endothelial cells (HCPEnC) with the human telomerase reverse transcriptase resulted in immortalized HCPEnC, which grew as monolayer with contact inhibition, formed capillary-like tubes in Matrigel, and showed no colony growth in soft agar. [iScience] |
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Sotatercept Analog Suppresses Inflammation to Reverse Experimental Pulmonary Arterial Hypertension | Researchers determined through genome-wide expression profiling that inflammatory and immune responses were prominently upregulated in the lungs of a Sugen-hypoxia rat model of severe angio-obliterative pulmonary arterial hypertension (PAH), concordant with profiles observed in PAH patients. [Scientific Reports] |
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Pro-Angiogenic Role of ZEB1 in Skin Wound Healing by Upregulating VEGFA via microRNA-206 Suppression | Cell and animal experiments were implemented to figure out whether zinc finger E-box binding homeobox 1 (ZEB1) orchestrated angiogenesis during skin wound healing. [Experimental Dermatology] |
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Apelin-Driven Endothelial Cell Migration Sustains Intestinal Progenitor Cells and Tumor Growth | The authors reported that in colorectal cancer, expansion of the stem/progenitor pool in intestinal crypts required VEGFA-independent growth and remodeling of blood vessels. [Nature Cardiovascular Research] |
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Syndecan-2 Selectively Regulates VEGF-Induced Vascular Permeability | Researchers reported that a proteoglycan, Syndecan-2, regulated the interaction between a transmembrane phosphatase, DEP1, and VEGFR2 by controlling cell surface levels of DEP1. [Nature Cardiovascular Research] |
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Organ-Specific Endothelial Cell Heterogenicity and Its Impact on Regenerative Medicine and Biomedical Engineering Applications | The authors highlight the main differences between different endothelial cell (EC) types, briefly summarize their different characteristics, and focus on the use of ECs in in vitro models. [Advanced Drug Delivery Reviews] |
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New Insight into Dyslipidemia-Induced Cellular Senescence in Atherosclerosis | Scientists summarize the current evidence for dyslipidemia-induced cellular senescence during atherosclerosis, with a focus on low-density lipoprotein and its modifications, hydrolysate of triglyceride-rich lipoproteins, and high-density lipoprotein. [Biological Reviews] |
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Oxurion Announces Top-Line Results from Part A of Phase II INTEGRAL Trial Evaluating THR-687 for Treatment of Diabetic Macular Edema (DME) | Oxurion NV announced top-line results from Part A of its Phase II trial of THR-687, an integrin antagonist, for the treatment of DME. [Oxurion NV] |
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| June 26 – July 1, 2022 Castelldefels, Spain |
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| Flanders Institute for Biotechnology (VIB) – Leuven, Belgium |
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| Johns Hopkins University School of Medicine – St. Petersburg, Florida, United States |
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| New York University College of Dentistry – New York, New York, United States |
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| University of Lausanne – Lausanne, Switzerland |
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