Endothelial Cell News Volume 7.20 | Jun 13 2022

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    Danielle Corrigan
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    2022-06-13 | ENDOCN 7.20


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.20 – 13 June, 2022
    TOP STORY

    Oncostatin M Triggers Brain Inflammation by Compromising Blood–Brain Barrier Integrity

    The authors investigated oncostatin M (OSM)’s role in pathological events important for the neuro-inflammatory disorder multiple sclerosis (MS) and showed that OSM receptor expression was increased on circulating lymphocytes of MS patients, indicating their elevated responsiveness to OSM signaling.
    [Acta Neuropathologica]

    Full Article


    View-On-Demand Webinar: Therapeutic Application of Endothelial Colony-Forming Cells. Watch Now.
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    IFN-γ–Dependent Tumor-Antigen Cross-Presentation by Lymphatic Endothelial Cells Promotes Their Killing by T Cells and Inhibits Metastasis

    Scientists assessed the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response.
    [Science Advances]

    Full Article

    Gatekeeping Role of NF2/Merlin in Vascular Tip EC Induction through Suppression of VEGFR2 Internalization

    Researchers showed that Merlin, encoded by the neurofibromatosis type 2 (NF2) gene, suppressed VEGF receptor 2 (VEGFR2) internalization depending on vascular endothelial-cadherin density and inhibited tip endothelial cell (EC) induction.
    [Science Advances]

    Full Article

    Hepatitis E Virus Infects Brain Microvascular Endothelial Cells, Crosses the Blood–Brain Barrier, and Invades the Central Nervous System

    By using an in vitro blood–brain barrier (BBB) model, the authors investigated whether Hepatitis E virus (HEV) could cross the BBB and whether the quasi-enveloped HEV virions were more permissible to the BBB than the nonenveloped virions.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Mosquito Saliva Enhances Virus Infection through Sialokinin-Dependent Vascular Leakage

    Scientists showed that the enhancement of infection by saliva was dependent on vascular function and was independent of most antisaliva immune responses, including salivary microbiota.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    The Onset of PI3K-Related Vascular Malformations Occurs during Angiogenesis and Is Prevented by the AKT Inhibitor Miransertib

    Researchers demonstrated that the Pik3caH1047R activating mutation in endothelial cells triggered a transcriptome rewiring that led to enhanced cell proliferation.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Paradoxical Role of β8 Integrin on Angiogenesis and Vasculogenic Mimicry in Glioblastoma

    Co-culture assays followed by Cell Counting Kit-8, migration, Matrigel tube formation, and sprouting assays were conducted to assess the proliferative, migratory, and angiogenic capacity of glioblastoma multiforme cells and human brain microvascular endothelial cells.
    [Molecular Psychiatry]

    Full Article

    Overexpression of Alanine-Glyoxylate Aminotransferase 2 Protects from Asymmetric Dimethylarginine-Induced Endothelial Dysfunction and Aortic Remodeling

    Upregulation of alanine-glyoxylate aminotransferase 2 led to lowering of asymmetric dimethylarginine (ADMA) levels and protection from ADMA-induced vascular damage in the setting of DDAH1 deficiency.
    [Scientific Reports]

    Full Article

    A Desirable Transgenic Strategy Using GGTA1 Endogenous Promoter-Mediated Knock-In for Xenotransplantation Model

    To develop a stable and efficient transgenic system, investigators knocked in internal ribosome entry sites-mediated transgenes into the α 1,3-galactosyltransferase (GGTA1) locus so that expression of these transgenes would be controlled by the GGTA1 endogenous promoter.
    [Scientific Reports]

    Full Article

    Guide to everything you need to know about cell separation.
    REVIEWS

    Comprehensive Insight into Endothelial Progenitor Cell-Derived Extracellular Vesicles as a Promising Candidate for Disease Treatment

    Scientists summarize the biogenesis and functions of endothelial progenitor cells (EPCs) and extracellular vesicles (EVs) and the potent role of EPC-EVs in the treatment of various diseases.
    [Stem Cell Research & Therapy]

    Full Article

    Role of Platelet-Derived Growth Factor C on Endothelial Dysfunction in Cardiovascular Diseases

    The authors summarize the information on the damage that high d-glucose causes on endothelial function and the beneficial effects that platelet-derived growth factor C could exert in cardiovascular diseases.
    [Biochimica Et Biophysica Acta-General Subjects]

    Full Article

    INDUSTRY AND POLICY NEWS

    Elevar Therapeutics Shares Results of Phase II Rivoceranib Trial in Patients with Progressive Recurrent or Metastatic Adenoid Cystic Carcinoma

    Elevar Therapeutics, Inc. detailed the results of its Phase II clinical trial of rivoceranib, an orally administered tyrosine kinase inhibitor, in patients with progressive recurrent or metastatic adenoid cystic carcinoma.
    [Elevar Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Musculoskeletal Biology and Bioengineering

    August 7 – 12, 2022
    Andover, New Hampshire, United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Neurovascular Research

    Huntington Medical Research Institutes – Pasadena, California, United States

    Postdoctoral Associate – Lung and Liver Injury in Sickle Cell Disease

    University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States

    Postdoctoral Position – Synthetic Biology and Regenerative Medicine

    University Medical Center Utrecht – Utrecht, Netherlands

    Postdoctoral Fellow – Tumor Microenvironment in Metastasis

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Project Scientist – Microvascular Determinants of Dementia

    UC Davis – Davis, California, United States

    > See All Jobs

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