Endothelial Cell News Volume 7.25 | Jul 28 2022

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    2022-07-18 | ENDOCN 7.25


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.25 – 18 July, 2022
    TOP STORY

    Immune and Endothelial Activation Markers and Risk Stratification of Childhood Pneumonia in Uganda: A Secondary Analysis of a Prospective Cohort Study

    Scientists assessed the ability of circulating host markers of immune and endothelial activation quantified at presentation, relative to currently used clinical measures of disease severity, to identify children with pneumonia who are at risk of death.
    [PLoS Medicine]

    Full Article
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    Gastric Cancer Cell-Derived Extracellular Vesicles Disrupt Endothelial Integrity and Promote Metastasis

    Cultured endothelial cells endocytosed cancer cell-derived extracellular vesicles, resulting in cytoskeletal rearrangement and low expression of the junction proteins cadherin and CD31, and formed large intercellular gaps allowing the transendothelial migration of cancer cells.
    [Cancer Letters]

    Abstract

    Synergistic Effect of VEGF and SDF-1α in Endothelial Progenitor Cells and Vascular Smooth Muscle Cells

    Endothelial progenitor cells were isolated from rat bone marrow and their morphology and function were studied.
    [Frontiers in Pharmacology]

    Full Article

    ANGPTL4 Attenuates Palmitic Acid-Induced Endothelial Cell Injury by Increasing Autophagy

    Investigators found that overexpression of ANGPTL4 in HUVECs enhanced cell proliferation and clone-forming ability in vitro, whereas knockdown of ANGPTL4 resulted in the opposite.
    [Cellular Signalling]

    Abstract

    Platycodin D Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis by Blocking the Activation of Mitogen-Activated Protein Kinases and the Production of Interleukin-8

    The authors found that platycodin D at noncytotoxic concentrations inhibited VEGF-induced proliferation, adhesion to the extracellular matrix proteins fibronectin and vitronectin, chemotactic motility, and tube formation of HUVECs.
    [American Journal of Chinese Medicine]

    Abstract

    Apolipoprotein A1 Enhances Endothelial Cell Survival in an In Vitro Model of ALS

    Researchers determined therapeutic potential of apolipoprotein A1 for endothelial cell repair under a pathological condition reminiscent of amyotrophic lateral sclerosis (ALS).
    [eNeuro]

    Abstract
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    REVIEWS

    Why Is Endothelial Resilience Key to Maintain Cardiac Health?

    The authors summarize how endothelial cells adjust to injury and how this dynamic response contributes to repair and regeneration.
    [Basic Research in Cardiology]

    Full Article

    Cerebral Malaria – Modeling Interactions at the Blood–Brain Barrier In Vitro

    Multiple in vitro models of the blood-brain barrier are available to investigate the mechanisms underlying the pathogenesis of cerebral malaria and other diseases.
    [Disease Models & Mechanisms]

    Full Article
    INDUSTRY AND POLICY NEWS

    Carl Zeiss Meditec and Precise Bio Announce Partnership in the Development and Commercialization of Tissue-Based Implants for Ophthalmology

    Carl Zeiss Meditec and Precise Bio announced that the companies have entered into a partnership to develop and commercialize fabricated corneal tissue for transplants in patients that require endothelial keratoplasty and natural lenticule transplants for treating keratoconus and vision correction.
    [Precise Bio (Cision US, Inc.)]

    Press Release
    FEATURED EVENT

    Advances in Therapeutic Applications of Stem Cells

    December 8 – 10, 2022
    Los Angeles, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Positions – Vascular Pathomechanisms

    University of Lausanne – Lausanne, Vaud, Switzerland

    Postdoctoral Fellow – Cancer Immunology

    Genentech, Inc. – South San Francisco, California, United States

    Research Associate – Cardiovascular Research

    King’s College London – London, England, United Kingdom

    Postdoctoral Position – Vascular Biology

    LMU Klinikum – München, Germany

    Postdoctoral Researcher – Translational Vascular Biology

    University Hospital of Muenster – Münster, Germany

    > See All Jobs

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