 | | Vol. 7.26 – 25 July, 2022 |
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| Scientists developed a microfluidics-enabled molding technique combined with coaxial bioprinting to fabricate anatomically relevant, cell-laden vascular models consisting of hydrogels.
[Small] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that inhibition of WNK1 promoted TGF-β–dependent degradation of the tyrosine kinase receptor AXL, which was involved in TGF-β–mediated cell migration and angiogenesis.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists reported distinct crosstalk between the insulin receptor and endoglin/activin receptor-like kinase 1, an endothelial cell-specific TGF-β receptor complex essential for angiogenesis.
[Journal of Biological Chemistry] |
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| Researchers showed that either the endothelium-specific deletion of Mtor to inhibit both mammalian target of rapamycin (mTOR) complexes, or depletion of Raptor or Rictor to disrupt mTORC1 or mTORC2, caused impaired endothelial-dependent vasodilatation.
[Communications Biology] |
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| Scientists experimentally investigated the SARS-CoV-2 infection in cultured human endothelial cells (ECs), and performed a comparative analysis for post-infection molecular events using early passage and replicative senescent ECs.
[Scientific Reports] |
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| Investigators elucidated the effect of combination therapy on gene and protein expression of HUVECs.
[Oncology Reports] |
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| Researchers investigated whether Astragalus polysaccharide promoted angiogenesis or vascularization via the TLR4 signaling pathway in a co-culture of outgrowth endothelial cells and primary human osteoblasts.
[Journal of Food Biochemistry] |
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| The authors review the pathogenesis and research progress of vascular calcification (VC), expound the role of endothelial cells in VC, and focus on the regulatory factors underlying endothelial-to-mesenchymal transition, with a view to providing new concepts for VC prevention and treatment.
[Frontiers in Cardiovascular Medicine] |
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| Lehigh University’s Aurelia Honerkamp-Smith, Assistant Professor of Physics, and Damien Thévenin, Associate Professor of Chemistry, have been awarded a National Institutes of Health (NIH) grant to test whether flow transport of a membrane protein triggers intracellular signaling in endothelial cells.
[Lehigh University] |
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| | Ohio State University Wexner Medical Center – Columbus, Ohio, United States |
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| | Goethe University – Frankfurt, Germany |
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| | University of Lausanne – Lausanne, Switzerland |
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| | Fralin Biomedical Research Institute at Virginia Tech Carilion – Roanoke, Virginia, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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