 | | Vol. 7.27 – 8 August, 2022 |
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| The authors showed that Grb2-associated binder 2 (Gab2) facilitated the assembly of the CARD recruited membrane-associated protein 3-B cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) signalosome, which mediated the activation of Rho and NF-kB in endothelial cells.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that mice had elevated lysophosphatidic acid (LPA) level in peripheral blood, as well as increased cardiac expression of its receptor LPA2 in the early stages after myocardial infarction.
[Circulation Research] |
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| Researchers investigated the mechanoregulation of uncoupling protein 2 (UCP2) expression in endothelial cells and the effect of UCP2 on endothelial inflammation and atherogenesis.
[Circulation Research] |
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| Scientists showed that HECTD3 deficiency in vascular endothelial cells significantly reduced tumor metastasis in multiple mouse models.
[Signal Transduction and Targeted Therapy] |
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| Using HUVECs, investigators showed that SOX9 expression alone was sufficient to activate mesenchymal genes and steer endothelial cells towards a mesenchymal fate.
[Nucleic Acids Research] |
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| Researchers found in a cohort of 319 patients with chronic kidney disease that plasma angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratios were positively associated with the development of kidney failure.
[Kidney International] |
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| Scientists investigated the role of exosomes derived from endothelial cells in arterial calcification and its potential mechanisms in end-stage renal disease.
[Cell Death & Disease] |
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| The authors analyzed the effects of octylmethoxycinnamate on rat aorta vasculature and explored the modes of action implicated in these effects.
[Chemosphere] |
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| The in vitro effects of AA147 and Ceapin-A7 in lipopolysaccharides-induced endothelial barrier dysfunction were investigated in bovine pulmonary artery endothelial cells.
[Cellular Signalling] |
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| Investigators categorize the current understanding of COVID-19-associated coagulopathy into three main pathological mechanisms: first, vascular endothelial cell dysfunction; second, a hyper-inflammatory immune response; and last, hypercoagulability.
[Nature Reviews Immunology] |
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| Akari Therapeutics, Plc announced positive results from recent pre-clinical studies on the tolerability and extended dose interval of long-acting PAS-nomacopan in development for geographic atrophy in dry age-related macular degeneration.
[Akari Therapeutics, Plc] |
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| November 12 – 16, 2022
San Diego, California, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | University Hospital of Muenster – Münster, Germany |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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