ESC & iPSC News 11.28 July 20, 2016 | |
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TOP STORYResearchers Coax Human Stem Cells to Rapidly Generate Bone, Heart Muscle Researchers mapped out the sets of biological and chemical signals necessary to quickly and efficiently direct human embryonic stem cells to become pure populations of any of 12 cell types, including bone, heart muscle and cartilage. [Press release from Stanford University discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Molecular Criteria for Defining the Naive Human Pluripotent State Researchers showed that transcription of transposable elements provides a sensitive measure of the concordance between pluripotent stem cells and early human development. [Cell Stem Cell] Full Article | Graphical Abstract | Press Release Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming Investigators devised a three-dimensional porous tissue engineering scaffold that could achieve successful and efficient induction of pluripotency. [ACS Appl Mater Interfaces] Abstract Function of Human Pluripotent Stem Cell-Derived Photoreceptor Progenitors in Blind Mice Investigators assessed the therapeutic potential of photoreceptor progenitors derived from human embryonic and induced pluripotent stem cells using a protocol that is suitable for future clinical trials. [Sci Rep] Full Article Identification of MMP1 as a Novel Risk Factor for Intracranial Aneurysms in ADPKD Using iPSC Models The authors generated induced pluripotent stem cells (iPSCs) from seven autosomal dominant polycystic kidney disease (ADPKD) patients, including four with intracranial aneurysm. [Sci Rep] Full Article Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells Scientists report a three-step protocol to differentiate human pluripotent stem cells into gonadotropin-releasing hormone-secreting neurons. [Stem Cell Reports] Full Article | Graphical Abstract Transcriptional and Epigenetic Mechanisms of Cellular Reprogramming to Induced Pluripotency The authors present current knowledge on the transcriptional and epigenetic regulation of pluripotency induction and discuss how variability in epigenetic states impacts induced pluripotent stem cells’ inherent biological properties. [Epigenomics] Abstract With the purpose to identify simultaneous expression profiling of microRNA, mRNA and protein, Illumina HiSeqâ„¢ 2000 System and iTRAQ-coupled 2D LC-MS/MS analysis were utilized in systemic lupus erythematosus-specific induced pluripotent stem cells (iPSCs) and normal control-iPSCs. [BMC Genomics] Full Article Scientists characterized the functionality of a novel 967bp OCT4-short response element during pluripotency and to examine the OCT4 titer-dependent response during differentiation to human derivatives not expressing OCT4. [Mol Ther Methods Clin Dev] Full Article | |
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REVIEWSAnti-Aging Strategies Based on Cellular Reprogramming The authors discuss how cellular reprogramming allows the recapitulation of aging in a dish, describing novel experimental approaches to investigate the aging process. [Trends Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSThrive Bioscience Announces Instruments and Services Agreement with the Harvard Stem Cell Institute Thrive Bioscience and the Harvard Stem Cell Institute announced an agreement under which Thrive will develop instruments for the growth and maintenance of induced pluripotent stem cells. [Thrive Bioscience] Press Release Regeneron Announces 2016 Winners of the Regeneron Prize for Creative Innovation Regeneron Pharmaceuticals, Inc. announced the winners of the fourth annual Regeneron Prize for Creative Innovation, an award designed to acknowledge, reward and foster talented early-career biomedical scientists. This year, Regeneron awarded $155,000 in prize money to 10 awardees and two institutions. [Regeneron Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSA Week of Political Bloodletting, but U.K. Science Minister Keeps His Job For researchers worried about the future of science in the United Kingdom, the news was something to hold onto. Late on Friday, Jo Johnson announced he will remain as science minister, despite a massive shakeup of the government cabinet. [ScienceInsider] Editorial Dutch Agency Launches First Grants Program Dedicated to Replication The Netherlands has launched what researchers say is the world’s first national fund dedicated to replication studies: a pot of €3 million over the next 3 years for Dutch scientists to test whether they can reproduce important research results in social and medical sciences. [Nature News] Editorial First Greek Science Agency Is Rare Source of Joy for Beleaguered Researchers A massive loan from the European Union’s investment bank gives Greek researchers their first ray of hope since the debt crisis hit six years ago: a government-backed plan to create a Greek research agency. [Nature News] Editorial
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EVENTSNEW 11th International BMP Conference Visit our events page to see a complete list of events in the ESC & iPSC community.
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JOB OPPORTUNITIESNEW Postdoctoral Positions – Epigenetic Inheritance and Cancer Epigenetics (Columbia University) NEW Industrial Research Manager – Regenerative Medicine and Tissue Engineering (KU Leuven) NEW Research Associate – Reprogramming and Chromatin (Imperial College London) Technical Sales Representative (STEMCELL Technologies Inc.) Research Technologist – Myogenic and Progenitor Cells (STEMCELL Technologies Inc.) Faculty Position – Biochemistry and Clinical Biochemistry (University of Poitiers) Postdoctoral Fellow – Pluripotent Stem Cell Technology (University of California, Davis) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Postdoctoral Fellow – Cancer Biology and Stem Cell Biology Research (City of Hope) Postdoctoral Fellow – Bioscience Research (The University of Tennessee Health Science Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home ESC & iPSC News Volume 11.28 | Jul 20 2016