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Pulmonary Cell News| ESC & iPSC News 11.36 September 14, 2016 | |
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TOP STORYGlycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State Investigators showed that naive human embryonic stem cells (hESCs) exhibit increased glycolytic flux, MYC transcriptional activity, and nuclear N-MYC localization relative to primed hESCs. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists report the development of a robust embryonic stem cell-based vascular differentiation assay amenable to small-molecule screens to identify novel modulators of angiogenesis. [Stem Cell Reports] Full Article Researchers characterized embryonic stem cell lines with Down syndrome (DS-ESCs), and focus on the neural aspects of the disease. They showed that neural progenitor cells differentiated from five independent DS-ESC lines display increased apoptosis and downregulation of forehead developmental genes. [Stem Cell Reports] Full Article | Graphical Abstract Scientists have developed a novel multicellular spheroid-based hepatic differentiation protocol starting from embryoid bodies of human induced pluripotent stem cells (iPSCs) for robust mass production of human hepatocyte-like cells using two novel inhibitors of the Wnt pathway. [Sci Rep] Full Article MicroRNA-302 Switch to Identify and Eliminate Undifferentiated Human Pluripotent Stem Cells Researchers synthesized a new RNA tool, microRNA (miR)-switch, as a live-cell reporter mRNA for miR-302a activity that can specifically detect human induced pluripotent stem cells (hiPSCs) down to a spiked level of 0.05% of hiPSCs in a heterogeneous population and can prevent teratoma formation in an in vivo tumorigenicity assay. [Sci Rep] Full Article Investigators developed an innovative three-dimensional culture substrate made of “nichoid” microstructures, nanoengineered via two-photon laser polymerization. They expanded mouse embryonic stem cells on the nichoid for two weeks. They compared the expression of pluripotency and differentiation markers induced in cells with that induced by flat substrates and by a culture layer made of kidney-derived extracellular matrix. [Stem Cell Res Ther] Full Article Researchers performed gene targeting in embryonic stem (ES) cells from the Sprague-Dawley and the Fischer 344 rat strains using an optimized procedure and the self-excising neomycin (neo)-positive selection cassette ACN to successfully generate Leptin and Trp53 knockout rats that did not carry the selection gene. [FEBS Lett] Abstract Investigators created porcine induced pluripotent stem cells with the expression of six reprogramming factors. The resulting cells showed growth dependent on leukemia inhibitory factor and expression of multiple stem cell markers. [J Cell Biochem] Abstract Scientists described the development of a robust, defined and xeno-free human pluripotent stem cell (hPSC) medium that supports reliable propagation of hPSCs and generation of human induced pluripotent stem cells from multiple somatic cell types; long-term serial subculturing of hPSCs with every-other-day medium replacement; and banking fully characterized hPSCs. [PLoS One] Full Article Effects of Long-Term Endocrine Disrupting Compound Exposure on Macaca mulatta Embryonic Stem Cells Scientists exposed rhesus monkey embryonic stem cells to low levels of five endocrine disrupting chemicals for 28 days, and evaluated effects on gene expression by RNAseq transcriptome profiling. [Reprod Toxicol] Abstract | |
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REVIEWSThe authors review the available literature on very small embryonic-like stem cells, the methods of their isolation and characterization, their ontogeny, how they compare with embryonic stem cells, primordial germ cells and induced pluripotent stem cells, and their role in maintaining tissue homeostasis. [Hum Reprod Update] Abstract The reviewers consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells that impact the desirability of each of these cell types for clinical use. [Stem Cells] Abstract Current Status in Cancer Cell Reprogramming and its Clinical Implications The authors discussed the recent findings in reprogramming cancer cells with a special emphasis on similarities between cancer cells and pluripotent cells. They presented the basis of challenges in cancer cell reprogramming including the current problems in reprogramming, cancer-specific epigenetic state and chromosomal aberrations. [J Cancer Res Clin Oncol] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSAllele Receives NIH Award to Fund the Development of Large-Scale Stem Cell Production The NIH’s National Heart, Lung, and Blood Institute has awarded Allele Biotechnology and Pharmaceuticals a Phase I SBIR grant to develop a novel manufacturing system to produce stem cell-derived human tissue and cells for clinical therapy. [Allele Biotechnology and Pharmaceuticals (Business Wire)] Press Release Asterias Biotherapeutics, Inc. presented positive interim efficacy data from the 10 million cell cohort in the company’s ongoing AST-OPC1 SCiSTAR Phase I/IIa multicenter clinical study in complete cervical spinal cord injury patients. [Asterias Biotherapeutics, Inc.] Press Release Cynata and FUJIFILM Sign Non-Binding Development and Commercialization Term Sheet Cynata Therapeutics Limited announced the execution of a term sheet with FUJIFILM Corporation of Japan for the development and commercialization of certain Cynata technology, including Cynata’s lead induced pluripotent stem cell derived therapeutic mesenchymal stem cell product, CYP-001 [Cynata Therapeutics Limited] Press Release | |
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POLICY NEWSOutsourcing, Coming Soon to a Lab near You A move toward outsourcing could offer entrepreneurial opportunities for scientists who have expertise that can be applied to doing experimental work for clients. Traditionally, companies started by scientists have sold products coming out of academic research. Scientific outsourcing firms, on the other hand, would sell the research process itself. [Science Careers] Editorial A Shady Market in Scientific Papers Mars Iran’s Rise in Science Iran’s parliament, the Majlis, is expected to take up work on a bill that would outlaw shady practices in scientific publishing. [Science] Editorial Medical Nobel Prize Committee Deals with Surgical Scandal In an unprecedented move, the group that selects the winners of the Nobel Prize in Physiology or Medicine — the Nobel Assembly — has asked two of its members to resign following a scandal at the institute that supplies the assembly’s members. [Nature News] Editorial
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EVENTSNEW Cell Culture & Downstream World Congress 2017 NEW World Advanced Therapies & Regenerative Medicine Congress 2017 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Chair – Medical Biology (Masaryk University) Research Technologist – Cancer Research (Penn State College of Medicine) Group Leader – Stem Cells and Aging (University of Queensland) PhD Studentship – Fibrosis (National University of Ireland, Galway) Assistant Professor – Developmental Biology (Washington University School of Medicine) Core Staff Scientist – Cancer Research (Moffitt Cancer Center) Postdoctoral Position – Regenerative Medicine (University of California, San Francisco) Postdoctoral Position – Cardiovascular Stem Cell Biology (Yale University) Industrial Research Manager – Regenerative Medicine and Tissue Engineering (KU Leuven) Postdoctoral Fellow – Pluripotent Stem Cell Technology (University of California, Davis) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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