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Pulmonary Cell News| ESC & iPSC News 11.38 September 28, 2016 | |
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TOP STORYEfficient Derivation of Microglia-Like Cells from Human Pluripotent Stem Cells Scientists established a robust and efficient protocol for the rapid production of microglia-like cells from human embryonic stem and induced pluripotent stem cells that uses defined serum-free culture conditions. [Nat Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)MERVL/Zscan4 Network Activation Results in Transient Genome-Wide DNA Demethylation of mESCs Investigators characterized the dynamics and consequences of a transient cell state. Single-cell transcriptomics identified the earliest upregulated transcripts as cells enter the MERVL/Zscan4 state. [Cell Rep] Full Article | Graphical Abstract The authors profiled the DNA methylome, transcriptome, and global occupancy of histone modifications in a series of mouse embryonic stem cells with varying DNA methylation levels to study the effects of DNA methylation on deposition of histone modifications. [Cell Rep] Full Article | Graphical Abstract Scientists attempted to generate induced pluripotent stem cells (iPSCs) from different subtypes of B-acute myeloid or lymphoid leukemia to address the developmental impact of leukemic fusion genes. OKSM(L)-expressing mono/polycistronic-, retroviral/lentiviral/episomal-, and Sendai virus vector-based reprogramming strategies failed to render iPSCs in vitro and in vivo. [Stem Cell Reports] Full Article | Graphical Abstract Researchers demonstrated an alternative concept for xeno-free expansion and differentiation of human induced pluripotent stem cells using synthetic substrates, which hinges on the structure-function relationship between electrospun polystyrene scaffolds and pluripotent stem cell growth. [Acta Biomater] Abstract The authors developed a stem-cell-based disease model by knocking-down the expression of Fmr1 in mouse embryonic stem cells (ESCs). Repressing fragile X mental retardation protein in ESCs increased the expression of amyloid precursor protein and Ascl1. [Stem Cells] Abstract The authors showed that the BTB domain-containing zinc finger protein CIBZ is expressed in mouse embryonic stem cells (ESCs) but is dramatically downregulated during ESC differentiation. [Sci Rep] Full Article Researchers designed an unbiased method to evaluate human pluripotent stem cell colony morphology. This method involves a combination of automated non-labelled live-cell imaging and the implementation of morphological colony analysis algorithms with multiple parameters. [Sci Rep] Full Article Folic Acid Supports Pluripotency and Reprogramming by Regulating LIF-STAT3 and MAPK-ERK Signaling Investigators found that folic acid sustained mouse embryonic stem cell (ESC) pluripotency and enabled long-term maintenance of the naïve state of ESC under CHIR99021 conditions. [Stem Cells Dev] Abstract Surprisingly gene trapping by the International Mouse Knockout Consortium to generate putative glyoxalase 1 (Glo1) knockout mice produced a mouse line with phenotype characterised as normal and healthy. Scientists showed that gene trapping mutation was successful but the presence of Glo1 gene duplication, likely in the embryonic stem cells before gene trapping, maintained wild-type levels of Glo1 expression and activity and sustained the healthy phenotype. [Biochem J] Abstract Epigenetics Changes Caused by the Fusion of Human Embryonic Stem Cell and Ovarian Cancer Cells The authors observed the effect of gene expression and tumorigenicity in hybrid cells of human embryonic stem cells (hESCs) and ovarian cancer cells in vitro and in vivo using a mouse model, and determined its feasibility in reprogramming tumor cells growth and apoptosis, for a potential exploration of the role of hESCs and tumor cells fusion in the management of ovarian cancer. [Biosci Rep] Abstract | |
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REVIEWSThe authors begin by focusing on recent findings that define roles for cell surface protein and lipid glycosylation in pluripotent stem cells and their functional impact during normal development. Then, they describe how patient derived induced pluripotent stem cells are being used to model human diseases such as congenital disorders of glycosylation. [Bioessays] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSAsterias Biotherapeutics, Inc. announced that the first patient with incomplete AIS-B cervical spinal cord injury was successfully dosed with 10 million cells of AST-OPC1 in the SCiSTAR clinical trial at Shepherd Center in Atlanta. [Asterias Biotherapeutics, Inc.] Press Release Cellular Dynamics International, Inc. announced a new venture, named Opsis Therapeutics. Opsis Therapeutics is focused on discovering and developing novel medicines to treat patients suffering from retinal diseases. [Cellular Dynamics International, Inc.] Press Release Cellular Dynamics International, Inc. announced the launch of iCell® Hepatoblasts, liver progenitor cells generated from human induced pluripotent stem cells. [Cellular Dynamics International, Inc.] Press Release | |
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POLICY NEWSWhy Big Pharma Wants to Collect 2 Million Genomes Five months after announcing its intentions to gather genome sequences from 2 million people, pharmaceutical giant AstraZeneca has selected geneticist David Goldstein to head up the task. [Nature News] Editorial Encourage Governments to Heed Scientific Advice The scientific community has seen its policy making influence rise worldwide over the past two decades. Researchers advise on decisions relevant to the scientific enterprise and on key issues from agriculture and environment to security, crime and economic growth. [Nature News] Editorial Zimbabwean Scientists Fight to Preserve National Academy Following years of chronic funding shortages and political neglect, the Zimbabwe Academy of Science (ZAS) is on its knees and has made a plea for support from the large Zimbabwean diaspora. The academy has historically survived on donations and membership fees, but this is no longer sustainable, said ZAS head Christopher Mutambirwa at a meeting of Zimbabwean expatriates in Johannesburg, South Africa. At the moment, the ZAS’s activities are voluntary and unpaid. [Nature News] Editorial Four Men and Two Women Are Running for the Top Slot at the World Health Organization The World Health Organization in Geneva, Switzerland, unveiled the names of the six candidates who are vying to succeed Margaret Chan as director-general. [Science Insider] Editorial Worldwide Brain-Mapping Project Sparks Excitement — and Concern In recent years, brain-mapping initiatives have been popping up around the world. They have different goals and areas of expertise, but now researchers will attempt to apply their collective knowledge in a global push to more fully understand the brain. [Nature News] Editorial
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EVENTSNEW Advances in Cell Engineering, Imaging and Screening NEW iPS Cell Training Course: Reprogramming Somatic Cells to iPS Cells NEW Challenges, Solutions and Progress in Stem Cell Medicine NEW The Biology of Regenerative Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Stem Cell Research (Stanford University) NEW Research Fellow – Pluripotent Stem Cells (KU Leuven) Research Technologist – Pluripotent Stem Cell Biology (STEMCELL Technologies Inc.) Faculty Position – Stem Cell Research (Children’s Research Institute) Assistant or Associate Member – Stem CellGene Therapy (Fred Hutchinson Cancer Research Center) Faculty Position – Stem Cell Biology and Regenerative Medicine (The Hospital for Sick Children) Chair – Medical Biology (Masaryk University) Research Technologist – Cancer Research (Penn State College of Medicine) Group Leader – Stem Cells and Aging (University of Queensland) Assistant Professor – Developmental Biology (Washington University School of Medicine) Core Staff Scientist – Cancer Research (Moffitt Cancer Center) Postdoctoral Position – Regenerative Medicine (University of California, San Francisco) Postdoctoral Fellow – Pluripotent Stem Cell Technology (University of California, Davis) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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