ESC & iPSC News 11.44 November 9, 2016 | |
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TOP STORYThe authors showed that transient promotion of cell survival through expression of the anti-apoptotic gene BCL2 enables EpiSCs and Sox17+ endoderm progenitors to integrate into blastocysts and contribute to chimeric embryos. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Cardiac Repair in Guinea Pigs with Human Engineered Heart Tissue from Induced Pluripotent Stem Cells Researchers created human engineered heart tissue strips from human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes and hiPSC-derived endothelial cells. [Sci Transl Med] Abstract Scientists demonstrated that growth-arrest-specific transcript 5 (GAS5), a known tumor suppressor and growth arrest-related long non-coding RNA, is highly expressed and directly regulated by pluripotency factors OCT4 and SOX2 in human embryonic stem cells. [Nat Commun] Full Article Synthetic Genome Readers Target Clustered Binding Sites Across Diverse Chromatin States The authors used cross-linking of small molecules to isolate chromatin coupled to sequencing to map the binding of two bioactive and structurally distinct polyamides to genomes directly within live H1 human embryonic stem cells. [Proc Natl Acad Sci USA] Abstract Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells Researchers performed mixing experiments to mimic the naturally occurring mosaicism in human pluripotent stem cell cultures and have assessed the sensitivity of chromosome banding, qPCR, fluorescence in situ hybridization, and digital droplet PCR in detecting variants. [Stem Cell Reports] Full Article CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells Scientists investigated the role of CITED2 in the specification of cardiac cell fate from mouse embryonic stem cells. [Stem Cell Reports] Full Article | Graphaical Abstract CRISPR/Cas9 Editing of Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues Researchers developed an imaging mass spectrometry method to enable simultaneous mass spectrometry in situ analysis of differentiated and undifferentiated induced pluripotent stem cell colonies in culture. [Arthritis Rheumatol] Abstract Scientists identified altered N-glycoproteins that significantly regulate cell adhesion processes in human induced pluripotent stem cells compared to human embryonic stem cells. [Sci Rep] Full Article Laminin-Guided Highly Efficient Endothelial Commitment from Human Pluripotent Stem Cells Investigators demonstrated that the directed switching of defined extracellular matrices robustly yields highly-purified endothelial progenitor cells without cell sorting from human pluripotent stem cells in an integrin-laminin axis-dependent manner. [Sci Rep] Full Article USP21 Deubiquitylates Nanog to Regulate Protein Stability and Stem Cell Pluripotency Stabilization of Nanog proteins is essential for embryonic stem cells. The ubiquitin–proteasome pathway mediated by E3 ubiquitin ligases and deubiquitylases is one of the key ways to regulate protein levels and functions. The authors identified the ubiquitin-specific peptidase 21 (USP21) as a deubiquitylase for Nanog, but not for Oct4 or Sox2. [Signal Transduct Target Ther] Full Article | |
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REVIEWSNeural Subtype Specification from Human Pluripotent Stem Cells Substantial progress has been made in guiding human pluripotent stem cells to regionally and functionally specialized neural subtypes. In this review scientists analyze the differentiation processes to reveal general principles and common strategies for specification of neural subtypes. [Cell Stem Cell] Abstract Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells The authors summarize the expanding field of pluripotent derived mesenchymal stem cells. [Stem Cell Rev] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSAxiogenesis and Metrion Biosciences Announce Stem Cell Collaboration Axiogenesis AG and Metrion Biosciences Ltd have signed a collaboration agreement to validate, optimize and commercialize iPSC-derived cell based assays to facilitate drug discovery and more accurately predict cardiac arrhythmia and neuronal risk. [Axiogenesis (PR Newswire Association LLC)] Press Release BioInvent Reports Clinical Hold on BI-505 Phase II Study BioInvent International has received verbal notice from the U.S. Food and Drug Administration that a full clinical hold has been placed on their current clinical Phase II study with the antibody BI-505 in patients with multiple myeloma undergoing autologous stem cell transplantation with high-dose melphalan. [BioInvent International] Press Release | |
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POLICY NEWSDonald Trump’s US Election Win Stuns Scientists Republican businessman and reality-television star Donald Trump will be the United States’ next president. Although science played only a bit part in this year’s dramatic, hard-fought campaign, many researchers expressed fear and disbelief as Trump defeated former secretary of state Hillary Clinton. [Nature News] Press Release Big Brain Projects Urged to Aid Public Health Major brain-mapping projects have multiplied in recent years, as neuroscientists develop new technologies to decipher how the brain works. These initiatives focus on understanding the brain, but the World Health Organization wants to ensure that they work to translate their early discoveries and technological advances into tests and treatments for brain disorders. [Nature News] Editorial Hard Work, Little Reward: Nature Readers Reveal Working Hours and Research Challenges A poll answered by thousands of Nature readers suggests that nearly two-thirds have considered quitting research, and that almost 40% work more than 60 hours in a week. The fight for funding is the greatest challenge facing early-career scientists, readers said. [Nature News] Editorial Twitterstorm Shows Why Scientific Evidence Matters Grammar and Twitter rarely sit happily, so it would be churlish to point out that when the Welsh MP Glyn Davies tweeted at the weekend: “Nothing more irritating than academics rubbishing the efforts of those operating at the sharp end, without facing up to the hard decisions”, he was inadvertently complaining that people at the sharp end (himself included presumably) do not confront hard decisions. [Nature News] Editorial
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EVENTSNEW 19th International Conference on Clinical Application of Adult Stem Cells Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Bioinformatics and Stem Cell Biology (Lund University) NEW Research Fellow – Metabolic Diseases (The Singapore Bioimaging Consortium) Postdoctoral Position – Human Pluripotent Stem Cells (University of Sheffield) NYSCF Investigator – Stem Cell And Neuroscience (New York Stem Cell Foundation) Postdoctoral Fellow – Neural Stem/Progenitor Cells (University of California – San Francisco) Research Fellow – Pluripotent Stem Cells Self-Renewal Program and Cell Cycle (KU Leuven) Faculty Position – Stem Cell Research (Stanford University) Faculty Position – Stem Cell Research (Children’s Research Institute) Assistant or Associate Member – Stem CellGene Therapy (Fred Hutchinson Cancer Research Center) Faculty Position – Stem Cell Biology and Regenerative Medicine (The Hospital for Sick Children) Postdoctoral Fellow – Pluripotent Stem Cell Technology (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home ESC & iPSC News Volume 11.44 | Nov 9 2016