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Pulmonary Cell News| ESC & iPSC News 12.28 July 19, 2017 | |
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TOP STORYInvestigators asked whether iPSC-derived primitive macrophages can terminally differentiate into specialized macrophages with the help of growth factors and organ-specific cues. [Immunity] Abstract | Graphical Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators demonstrated not only distinct energy metabolisms in primordial germ cells (PGCs) and pluripotent stem cells (PSCs), but also the essential contribution of enhanced oxidative phosphorylation and glycolysis in PGC specification from PSCs, and in reprogramming of PGCs into PSCs, respectively. [Proc Natl Acad Sci USA] Abstract Scientists performed a head-to-head comparison of ESC-cardiomyocytes and iPSC-cardiomyocytes in their ability to restore cardiac function in a rat myocardial infarction model as well as their exosomal secretome. [Stem Cells] Abstract Elimination of Undifferentiated Human Embryonic Stem Cells by Cardiac Glycosides Researchers demonstrated the cytotoxic effects of cardiac glycosides, such as digoxin, lanatoside C, bufalin, and proscillaridin A, in human embryonic stem cells. [Sci Rep] Full Article The authors investigated whether transient expression of Paired Box 7 Protein (PAX7) using minicircle DNA would enable the generation of functional pluripotent stem cell-derived myogenic progenitors, equivalent to those generated by lentivirus. [Stem Cell Res] Full Article Investigators transplanted undifferentiated human induced pluripotent and embryonic stem cells into the adult mouse brain ventricle and analyzed their fates. [Stem Cells Dev] Abstract Scientists demonstrated that aligned microfibrous scaffolds induced human induced pluripotent stem cell-derived cardiomyocytes alignment along the direction of the aligned microfibers after two days of human induced pluripotent stem cell-derived cardiomyocyte (iCM) seeding, as well as promoted greater iCM maturation by increasing the sarcomeric length and gene expression of myosin heavy chain adult isoform, in comparison to randomly oriented scaffolds. [Biomater Sci] Abstract Functional Expression of the Ca2+ Signaling Machinery in Human Embryonic Stem Cells Researchers used RT-PCR and Western blotting to analyze the expression profiles of genes encoding Ca2+-handling proteins; we also used confocal Ca2+ imaging and pharmacological approaches to determine the contribution of the Ca2+-handling machinery to the regulation of Ca2+ signaling in hESCs. [Acta Pharmacol Sin] Abstract Development of Membrane Ion Channels During Neural Differentiation from Human Embryonic Stem Cells Investigators attempted to determine the changes in expression of voltage gated channels and their electrophysiological properties during neural differentiation. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSManufacturing Cell Therapies Using Engineered Biomaterials The authors discuss the use of engineered biomaterials to control human cell manufacturing. [Trends Biotechnol] Abstract Small Molecules for Reprogramming and Transdifferentiation Investigators discuss the recent progress, new insights, and future challenges about the use of small molecules in cell fate conversion. [Cell Mol Life Sci] Abstract Application of Human Induced Pluripotent Stem Cells to Model Fibrodysplasia Ossificans Progressiva Scientists discuss how the application of hiPSCs technology to studying fibrodysplasia ossificans progressiva (FOP) has changed our perspectives on FOP disease pathogenesis. They also consider ongoing challenges and emerging opportunities for the use of human iPSCs in drug discovery and regenerative medicine. [Bone] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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SCIENCE NEWSBioTime, Inc. announced that an abstract related to the Company’s retinal tissue implant has been accepted for a paper presentation. The abstract is titled, “Phase I and IIa Study of Human Embryonic Stem Cell–Derived Retinal Pigment Epithelial Cells Transplanted Subretinally in Advanced Dry-Form AMD Patients.” [Press release from BioTime, Inc. discussing research to be presented at the American Academy of Ophthalmology (AAO) annual meeting, New Orleans] Press Release | |
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INDUSTRY NEWSISSCR Opposes U.S. Ban on Federal Funding for Fetal Tissue Research The ISSCR opposes a provision of the U.S. House of Representatives Labor-HHS-Education FY18 Appropriations bill that would ban federal funding for fetal tissue research. If enacted, this legislation would severely impede research that is necessary for the development of new treatments for a wide range of serious and incurable diseases. It would have a devastating effect on the future of biomedical advances and regenerative medicine. [International Society for Stem Cell Research] Press Release Asterias Biotherapeutics, Inc. announced completion of enrollment and dosing of the AIS-A twenty million cell cohort in the company’s ongoing SCiStar Phase I/IIa clinical study of AST-OPC1 in complete cervical spinal cord injury. [Asterias Biotherapeutics, Inc] Press Release Pairnomix Teams Up With StemoniX To Co-Develop New Epilepsy Model Pairnomix, LLC and StemoniX announced a new strategic partnership. The partnership will combine Pairnomix’s expertise in epilepsy modeling with StemoniX’s proprietary microBrain® technology to create a new in vitro seizure-in-a-dish model system. [Pairnomix, LLC (PRNewswire)] Press Release | |
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POLICY NEWSRelatively Few NIH Grantees Get Lion’s Share of Agency’s Funding The rich have been getting richer in the biomedical research enterprise, and the system favors those who are already doing pretty well, according to a new analysis of National Institutes of Health (NIH) grant recipients. [ScienceInsider] Editorial Two Female Scientists Sue Salk Institute, Alleging Discrimination at ‘Old Boys Club’ Two senior female scientists are suing their employer, the prestigious Salk Institute for Biological Studies, alleging pervasive, long-standing gender discrimination. In the pair of lawsuits, filed in California Superior Court in San Diego, plaintiffs Vicki Lundblad and Katherine Jones seek unspecified compensation for an array of harms. [ScienceInsider] Editorial Johnson Calls on House to Include Right to Try in FDA Reauthorization Bill Sen. Ron Johnson (R-Wis.) released a statement calling on House leadership to include right to try language in the House FDA Reauthorization bill. [Committee on Homeland Security and Governmental Affairs] Press Release
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EVENTSNEW Annual Congress on Tissue Engineering and Bio-Banking Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Junior Principal Investigator – Molecular Oncology (FIRC Institute of Molecular Oncology) NEW Assistant Professor – Stem Cell and Regenerative Biology (Harvard University) Doctoral Grant – 3D Culture of Pluripotent Stem Cell-Derived Brain Organoids (University of Antwerp) Postdoctoral Fellow – Stem Cell Tissue Engineering (Stanford University) Senior/Principal Scientist – Stem Cell Research (Plasticell Ltd) Laboratory Research Technician – Epigenetics of Stem Cells (Albert Einstein College of Medicine) Postdoctoral Position – Epigenetics of Pluripotent Stem Cells (Albert Einstein College of Medicine) Postdoctoral Fellow – Bioinformatics (Stanford University) Postdoctoral Fellow – Multiple Areas (University of Oklahoma) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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