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Pulmonary Cell News| ESC & iPSC News 12.32 August 16, 2017 | |
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TOP STORYResearchers describe how to efficiently direct hPSCs differentiation into self-renewing epicardial cells in a completely defined, xeno-free system by temporal modulation of regulators of canonical Wnt signaling. [Nat Protoc] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)A p53-Dependent Response Limits the Viability of Mammalian Haploid Cells A substantial proportion of the haploids die at or shortly after the last mitosis through activation of a p53-dependent cytotoxic response. Investigators showed that p53 deletion stabilizes haploidy in human HAP1 cells and haploid mouse embryonic stem cells. [Proc Natl Acad Sci USA] Abstract Mobilization of LINE-1 Retrotransposons Is Restricted by Tex19.1 in Mouse Embryonic Stem Cells Loss of Tex19.1 increased LINE-1 (L1)-ORF1p levels and L1 mobilization in pluripotent mouse embryonic stem cells, implying that Tex19.1 prevented de novo retrotransposition in the pluripotent phase of the germline cycle. [eLife] Full Article Adoption of the Q Transcriptional System for Regulating Gene Expression in Stem Cells Researchers established a novel genetic tool, called LacQ, that functions to regulate gene expression in Chinese hamster ovarian cells, human embryonic kidney 293 cells, and in mouse ESCs. [ACS Synth Biol] Abstract | Graphical Abstract Scientists describe the first nuclear interactor of ARF and Mdm2 (Niam) embryonic stem cell interactome, which includes proteins with roles in DNA replication and repair, transcription, splicing and ribosome biogenesis. [Sci Rep] Full Article Totipotency Segregates between the Sister Blastomeres of Two-Cell Stage Mouse Embryos Investigators achieved reliable quantification of the prevalence of dual totipotency among mouse two-cell stage blastomeres. [Sci Rep] Full Article Epigenetic Barrier against the Propagation of Fluctuating Gene Expression in Embryonic Stem Cells Correlation between Pou5f1 and Zfp42 fluctuations was demonstrated in ESCs containing a knockout in the NuRD component Mbd3. ESCs containing a triple knockout in the DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b showed correlation between the fluctuation of Pou5f1, Zfp42 and Nanog gene expression. [FEBS Lett] Abstract Researchers developed a novel protocol to differentiate hESCs into corneal epithelial progenitor cells, with similar features to primary cultured human limbal stem cells, using a medium composed of DMEM/F12 and defined keratinocyte serum-free medium under different carbon dioxide levels in culture. [PLoS One] Full Article Purification of Functional Reprogramming Factors in Mammalian Cell Using FLAG-Tag Scientists previously generated human iPSCs using cell extracts with cell penetration peptide for the delivery of reprogramming proteins. Here, they showed that the expression of reprogramming factors in mammalian cells and subsequent purification of these factors by FLAG-Tag could reprogram fibroblasts into iPSCs. [Biochem Biophys Res Commun] Full Article | |
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REVIEWSThe Interplay of Epigenetic Marks during Stem Cell Differentiation and Development New advances in genome-wide technologies have paved the way towards an integrative view of epigenome dynamics during cell state transitions, and recent findings in embryonic stem cells highlight how the interplay between different epigenetic layers reshapes the transcriptional landscape. [Nat Rev Genet] Abstract Signaling Networks in the Control of Pluripotency The authors discuss signaling networks in both mouse and human ESCs, focusing on signals involved in the control of self-renewal and differentiation. The modulation of signaling pathways by pluripotency-associated transcription factors is also summarized. [Curr Opin Genet Dev] Abstract Human Induced Pluripotent Stem Cells as a Research Tool in Alzheimer’s Disease Researchers review current literature using iPSCs to study Alzheimer’s disease, describe drug discovery efforts using this platform, and discuss the future potential for this technology in psychiatry research. [Psychol Med] Abstract The miR-290-295 Cluster as Multi-Faceted Players in Mouse Embryonic Stem Cells Scientists review the research progress of the function of the miR-290-295 cluster in embryonic stem cells. The miR-290-295 cluster is involved in regulating embryonic stem cell pluripotency maintenance, self-renewal, and reprogramming somatic cells to an embryonic stem cell-like state. [Cell Biosci] Full Article Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSBlueRock Therapeutics announced the expansion of the company’s presence in Toronto with a research, development and manufacturing site in the MaRS Discovery District. [BlueRock Therapeutics] Press Release BioTime Announces $2 Million Grant for Further Development of OpRegen® for Dry-AMD BioTime, Inc. has been awarded a new grant for 2017 of up to 7.2 million Israeli New Shekels from the Israel Innovation Authority (IIA). The grant provides funding for the continued development of OpRegen®, and to date the IIA has provided annual grants totaling approximately $12 million. [BioTime, Inc.] Press Release | |
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POLICY NEWSChina’s Embrace of Embryo Selection Raises Thorny Questions Fertility centers are making a massive push to increase preimplantation genetic diagnosis in a bid to eradicate certain diseases. [Nature News] Editorial Americans Are Becoming More Open to Human Genome Editing, Survey Finds, but Concerns Remain Earlier surveys of Americans found a reluctance to support human genome editing, with many respondents expressing ethical and other concerns about such intentional tinkering. A new survey found that two-thirds of the 1600 respondents thought genome editing was generally “acceptable.” But that acceptance was qualified, and colored by religious beliefs and scientific knowledge. [ScienceInsider] Editorial Budget Cuts Fuel Frustration among Japan’s Academics Japan’s premier scientific research institution, RIKEN, turned 100 this year, and celebrated with a grand ceremony attended by the empress and emperor. But not everybody was in the mood to party. In the old days, RIKEN was known as a paradise for scientists because of its generous funding. No longer: as Japan cuts off funds in the face of continuing financial uncertainty, the cracks are starting to show. [Nature News] Editorial New FDA Security Rules Will Bar Agency from Hiring Some Foreign Nationals The FDA is moving to adopt a new policy on security background checks that is sowing confusion and alarm among some of its scientists. The change, described in a “communications plan” shared with the agency’s senior staff in recent weeks, appears to effectively bar the agency from hiring—as employees or contractors—foreign nationals who have not lived in the United States for a total of three out of the last five years. [ScienceInsider] Editorial
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EVENTSNEW Keystone Symposia: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering NEW EBiSC Workshop on “Scalability of the iPSC Technology for Future Drug Discovery & Therapy” Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Cellular Neuroscience/Stem Cell (UC San Diego) Postdoctoral Position – Mammalian Stem Cell Biology (New York University, School of Medicine) Assistant Professor – Human Anatomy and Cell Science (University Of Manitoba) Assistant Professor – Stem Cell and Regenerative Biology (Harvard University) Post-Doctoral/PhD Position – Stem Cell Biology & Metabolism (University of Freiburg) Junior Principal Investigator – Molecular Oncology (FIRC Institute of Molecular Oncology) Assistant Professor – Stem Cell and Regenerative Biology (Harvard University) Postdoctoral Fellow – Stem Cell Tissue Engineering (Stanford University) Laboratory Research Technician – Epigenetics of Stem Cells (Albert Einstein College of Medicine) Postdoctoral Position – Epigenetics of Pluripotent Stem Cells (Albert Einstein College of Medicine) Postdoctoral Fellow – Multiple Areas (University of Oklahoma) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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