ESC & iPSC News 12.41 October 18, 2017 | |
| |
TOP STORYResearchers report that depleting Spt6 in embryonic stem cells reduced expression of pluripotency factors, increased expression of cell-lineage-affiliated developmental regulators, and induced cell morphological and biochemical changes indicative of ESC differentiation. [Mol Cell] Abstract | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)The authors profiled genome-wide transcriptional activity and a variety of epigenetic marks in the regulatory DNA elements using massive RNA-seq and ChIP-seq in human endothelial cells, cardiac progenitor cells, fibroblasts, and their respective induced pluripotent stem cells. [Circ Res] Abstract Scientists investigated the impact of reprogramming on organ-specific DNA methylation by generating human induced pluripotent stem cell (hiPSC) lines from six isogenic organs. All isogenic hiPSCs acquired DNA methylation patterns comparable to existing hPSCs. [Nat Commun] Full Article The WNT Target SP5 Negatively Regulates WNT Transcriptional Programs in Human Pluripotent Stem Cells Investigators used human pluripotent stem cells to study the dynamics of the transcriptional response to exogenous activation of the WNT pathway. They describe a mechanism involving the WNT target gene SP5 that leads to termination of the transcriptional program initiated by WNT signaling. [Nat Commun] Full Article The authors demonstrated that SIRT1-deficient mouse ESCs are hypersensitive to methionine restriction/depletion-induced differentiation and apoptosis, primarily due to a reduced conversion of methionine to S-adenosylmethionine. [EMBO J] Abstract | Graphical Abstract Gadd45a Opens up the Promoter Regions of miR-295 Facilitating Pluripotency Induction Researchers showed that growth arrest and DNA-damage-inducible protein 45a (Gadd45a) enhances reprogramming by activating miR-295. They also showed that Gadd45a binds the promoter regions of miR-295. [Cell Death Dis] Full Article Through an analysis of the PSC-secreted proteins, Activin A was found to impede epiblast (EPI) lineage development while promoting trophectoderm differentiation, resulting in replacement of the EPI lineage of host embryos with PSCs. [Protein Cell] Full Article Ctbp2-Mediated β-Catenin Regulation Is Required for Exit from Pluripotency The authors demonstrated that C-terminal-binding protein 2 (Ctbp2) associates with major components of the β-catenin destruction complex and limits the accessibility of β-catenin to core transcription factors in undifferentiated ESCs. [Exp Mol Med] Full Article Scientists provide a detailed insight into genetic and epigenetic changes associated with human ESCs differentiation into cardiac cells and a role for NR2F2 was deciphered for the first time to down-regulate OCT-4 via EZH2 during cardiac differentiation. [Sci Rep] Full Article HLA and Histo-Blood Group Antigen Expression in Human Pluripotent Stem Cells and Their Derivatives Investigators explored immune determinants of human embryonic stem cell lines and induced human pluripotent stem cell lines and hepatocyte- and cardiomyocyte-like cells derived from these cells. [Sci Rep] Full Article | |
| |
REVIEWS3D Bioprinting Using Stem Cells The authors discuss the current advances, applications, limitations and future of 3D bioprinting using stem cells, by organ systems. [Pediatr Res] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
| |
INDUSTRY NEWSPlasticell and GSK Sign Collaboration Agreement to Produce Hematopoietic Cells From iPSCs Plasticell has entered into a collaboration with GSK to use its combinatorial stem cell screening technology, CombiCult®, to optimise the directed differentiation of induced pluripotent stem cells to specific blood cell lineages for use by GSK in its therapeutic research. [Plasticell Ltd.] Press Release National Academy of Medicine Honors Three Members for Outstanding Service The National Academy of Medicine honored three members at its annual meeting for their outstanding service. The honorees were Barbara J. McNeil, Richard O. Hynes and Ruth R. Faden. Hynes co-chaired high-profile committees on two politically sensitive topics — embryonic stem cell research and human genome editing — which produced seminal reports that have, or are poised to, shape the parameters of public debate and the policies and regulation of these fields. [National Academy of Sciences] Press Release | |
| |
POLICY NEWSEfforts to Save Leading Hungarian University Hit Hurdle The threatened Central European University in Budapest has been dealt a blow in its efforts to avert possible closure in Hungary. The country’s parliament voted to postpone, for a year, a decision that would allow the university to keep operating there. [Nature News] Editorial New Definitions of Scientific Units Are on the Horizon Revamped definitions of scientific units are on their way. In the biggest overhaul of the international system of units since its inception in 1960, a committee is set to redefine four basic units — the ampere, the kilogram, the kelvin and the mole — using relationships to fundamental constants, rather than abstract or arbitrary definitions. [Nature News] Editorial Top Chinese University to Consider Social-Media Posts in Researcher Evaluations One of China’s most prestigious universities plans to give some articles in newspapers and posts on major social-media outlets the same weight as peer-reviewed publications when it evaluates researchers. [Nature News] Editorial
| |
EVENTSNEW 2018 Cell Dynamics Symposium Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Position – Bioengineering and Regenerative Medicine (Maastricht University) Research Technologist – Pluripotent Stem Cell Biology (STEMCELL Technologies Inc.) Head of Facility – Gene Editing and Embryology (European Molecular Biology Laboratory) Doctoral Grant – Pluripotent Stem Cell-Derived Brain Organoids (University of Antwerp) Faculty Positions – Stem Cells or Organoid Models (Center for Stem Cell & Organoid Medicine) Postdoctoral Position – Stem Cells, Development and Cancer (Albert Einstein College of Medicine) Postdoctoral Position – Wound Healing (University of Connecticut Health Center) Postdoctoral Fellowship – Cell Biology of Tubulogenesis (University of Copenhagen) Technical Director – Personalized Stem Cell Banking (Brilliant Research) Faculty Position – Stem Cell Research (University of Texas Southwestern Medical Center) Postdoctoral Fellow – Stem Cell Research (Tsinghua University) Postdoctoral Fellow – Stem Cell Tissue Engineering (Stanford University) Postdoctoral Fellow – Multiple Areas (University of Oklahoma) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in ESC & iPSC News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|