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Pulmonary Cell News| ESC & iPSC News 13.01 January 10, 2018 | |
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TOP STORYEngineers Grow Functioning Human Muscle from Skin Cells Biomedical engineers have grown the first functioning human skeletal muscle from induced pluripotent stem cells. [Press release from Duke University discussing online prepublication in Nature Communications] Press Release | Full Article | Video | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that transfection of adult fibroblasts with specific LNA Gapmers induces a robust downregulation of Zeb2-NAT transcripts and Zeb2 protein and enhances the reprogramming of old fibroblasts into pluripotent cells. [Nat Commun] Full Article Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids The authors describe the derivation of skin organoids, constituting epidermal and dermal layers, from a homogeneous population of mouse pluripotent stem cells in a 3D culture. They showed that skin organoids spontaneously produce de novo hair follicles in a process that mimics normal embryonic hair folliculogenesis. [Cell Rep] Full Article | Press Release | Graphical Abstract Researchers showed that a null mutation in TRIM28 causes significant alterations in transposable element expression in both the naive and primed states of human pluripotency, and phenotypically this has limited effects on self-renewal, instead causing a loss of germline competency. They discovered that TRIM28 regulates paternal imprinting control region (ICR) methylation and chromatin accessibility in the primed state, with no effects on maternal ICRs. [Stem Cell Reports] Full Article | Graphical Abstract Investigators demonstrated that distinct mesenchymal subpopulations co-emerge from mesoderm during human PSC differentiation. Despite co-expression of common mesenchymal markers, a subset of cells defined as CD146hiCD73hi expressed genes associated with the hematopoietic stem/progenitor cell (HSPC) niche and supported the maintenance of functional HSPCs ex vivo, while CD146loCD73lo cells supported differentiation. [Stem Cell Reports] Full Article Transient MicroRNA Expression Enhances Myogenic Potential of Mouse Embryonic Stem Cells Investigators analyzed differentiation of two ESC lines – D3 and B8, and observed significant differences in the expression of miRNAs and genes involved in pluripotency and differentiation. They also examined if transient miRNA overexpression could serve as a sufficient impulse modulating differentiation of mouse ESCs. [Stem Cells] Abstract Scientists explored the two antagonistic effects of retinoic acid (RA) on human iPSCs. Although RA has been widely described as a pharmacological agent with a critical role in initiating differentiation of pluripotent stem cells, they demonstrated that short-term RA exposure not only antagonizes cell differentiation and sustains pluripotency of human iPSCs, but it also boosts and improves their properties and characteristics. [Cell Death Dis] Full Article Differentiation Potential of Pluripotent Stem Cells Correlates to the Level of CHD7 The authors showed the differentiation potential and growth rate of ESC correlates positively with the expression level of the gene encoding chromodomain helicase DNA binding protein 7 (CHD7). [Sci Rep] Full Article Researchers used mouse ESCs to study the function of tousled-like kinase 1 (Tlk1) in pluripotent cells. The knockdown-based Tlk1-deficient cells showed that Tlk1 is not essential for ESC self-renewal in an undifferentiated state. [Sci Rep] Full Article The authors report the effect of multivariate perturbations on human ESC differentiation, enabled by the development of high throughput 3D alginate array platform. Specifically, the sensitivity of human ESC propagation and pancreatic differentiation to substrate properties and cell culture configuration was analyzed. [Biotechnol J] Abstract Scientists investigated the effect of HO-1 (Hmox1) or Nrf2 (Nfe2l2), two major cytoprotective genes. Hmox1–/– fibroblasts demonstrated decreased reprogramming efficiency in comparison to Hmox1+/+ cells. Decreased reprogramming efficiency was also observed in Nrf2-lacking fibroblasts. [IUBMB Life] Abstract | |
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REVIEWSTowards Stem Cell Based Therapies for Parkinson’s Disease Now it is possible to generate authentic midbrain dopaminergic neurons from pluripotent stem cells and clinical trials using such cells are rapidly approaching. [Development] Full Article Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSGenCure, a subsidiary of BioBridge Global, opened the first phase of a new biomanufacturing center designed to address a critical roadblock slowing the advancement of cellular therapies and the field of regenerative medicine: A lack of access to large-scale stem cell manufacturing and support services required for Current Good Manufacturing Process-compliant production of biologics for use in human clinical trials and commercial manufacturing. [GenCure (GlobeNewswire, Inc.)] Press Release The FDA has agreed to allow Mayo Clinic to use an automated bioreactor-based stem cell production platform on its campus in Jacksonville, Florida. This enables the Mayo Clinic Center for Regenerative Medicine to produce cells from the bone marrow of a stem cell donor in quantities large enough to make several doses that can be used as treatments in clinical trials. [Mayo Clinic] Press Release Cellular Dynamics International (CDI) announced that its iCell® Cardiomyocytes were launched into space via SpaceX’s 13th commercial resupply services mission to the International Space Station. The purpose of the scientific research project utilizing CDI’s iCell Cardiomyocytes in space is to validate the function of NASA’s new Bioculture System for automated cell culture on the International Space Station and to study human cardiac cell function in microgravity. [Cellular Dynamics International (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSKoch-Backed Groups Urge Congress to Pass Right-to-Try Legislation Several deep-pocketed political advocacy groups founded by Charles and David Koch are ramping up their advocacy before Congress on a niche issue: access to experimental drugs. [STAT News] Editorial Faced with Public Pressure, Research Institutions Step Up Reporting of Clinical Trial Results The reporting of clinical trial results to a public database — mandated by a ten-year-old federal law — has improved sharply in the last two years, with universities and other nonprofit research centers leading the way. [STAT News] Editorial
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EVENTSNEW Pluripotent Stem Cell Training Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Scientist – Stem Cell Research (Evotec AG) Postdoctoral Research Fellows – Bioengineering and Nanotechnology (The University of Queensland) Postdoctoral Position – Regenerative Medicine (University of Pennsylvania) Investigator – Stem Cell (Blood Research Institute) Postdoctoral Fellows – Stem Cell Biology and Regenerative Medicine (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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