ESC & iPSC News 13.09 March 7, 2018 | |
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TOP STORYThe authors carried out a genome-wide screen to systematically dissect the regulation of the euchromatic state of ESCs. They revealed that cellular growth pathways, most prominently translation, perpetuate the euchromatic state and hypertranscription of ESCs. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Microhomology-Assisted Scarless Genome Editing in Human iPSCs Investigators present a method for scarless selection marker excision using engineered microhomology-mediated end joining. By overlapping the homology arms of standard donor vectors, short tandem microhomologies are generated flanking the selection marker. [Nat Commun] Full Article Researchers compared reprogramming efficiency of five different retinal cell types at two different stages of development. Retinal differentiation from each iPSC line was measured using a quantitative standardized scoring system called STEM-RET and compared to the epigenetic memory. [Cell Rep] Full Article | Graphical Abstract Scientists report the role of Yin Yang 1 (YY1) and BAF complex in the OCT4-mediated pluripotency network in mouse embryonic stem cells (mESCs). The interaction between YY1 and BAF complex promotes mESC proliferation and pluripotency. [Stem Cell Reports] Full Article | Graphical Abstract Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy Using a genetic selection strategy, researchers were able to highly enrich ISL1+ cells derived from human embryonic stem cells. [Stem Cell Reports] Full Article Scientists demonstrated that changes in mitochondrial morphology from a small granular fragmented phenotype in pluripotent stem cells to a filamentous reticular elongated network in differentiated cardiomyocytes are required for cardiac mesodermal differentiation. [Cell Death Discov] Full Article Insights into the Ubiquitin-Proteasome System of Human Embryonic Stem Cells The authors defined which E3 enzymes are increased in human ESCs compared with their differentiated counterparts. Among them, they found HECT-domain E3 ligases such as HERC2 and UBE3A as well as several RING-domain E3s, including UBR7 and RNF181. [Sci Rep] Full Article | Press Release Researchers describe a growth-factor-free culture medium that uses just three chemical compounds and a lower number of recombinant proteins than used in commercially available media. They showed that the culture medium supports the long-term propagation of human PSCs, as confirmed by karyotype, the expression of pluripotency markers and the capacity to differentiate into cell types derived from the three embryonic germ layers. [Nat Biomed Eng] Abstract A human iPS cell line was generated from skin fibroblasts of a subject at the presymptomatic life stage, carrying a polyglutamine expansion in HTT gene codifying Huntingtin protein. [Stem Cell Res] Full Article | |
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REVIEWSResearchers review recent developments in iPSC research on regenerating injured heart tissue, including novel advances in cell therapy and potential strategies to overcome current obstacles in the field. [Mol Ther] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSAsterias Provides Update for Its AST-OPC1 Phase I/IIa Clinical Trial in Severe Spinal Cord Injury Asterias Biotherapeutics, Inc. provided additional data from the company’s ongoing Phase I/IIa SCiStar study designed to evaluate the safety and potential efficacy of AST-OPC1 in the treatment of severe cervical spinal cord injury. [Asterias Biotherapeutics, Inc.] Press Release BioTime Announces DSMB Approval to Proceed to Cohort 4 of the OpRegen® Clinical Trial BioTime, Inc. announced that the independent Data Safety Monitoring Board (DSMB) has approved initiation of the fourth cohort for the ongoing OpRegen® clinical trial. [BioTime, Inc.] Press Release | |
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POLICY NEWSRise of Nationalist and Populist Parties Has Italian Scientists Worried The outcome of Sunday’s parliamentary elections in Italy was a stunning victory for populist and nationalist parties, and a clear warning to Italy’s political establishment and the European Union. But some in Italy worry that the results may also have a negative impact on science. [ScienceInsider] Editorial What Researchers Can Expect from China’s Top-Level Political Meetings As Chinese leaders gather for the government’s most significant meetings of the year, researchers are anticipating major policy announcements for science and innovation that could shape the country’s research agenda for years. [Nature News] Editorial New NSF Rules on Sexual Harassment Leave Many Questions Unanswered The National Science Foundation (NSF) in Alexandria, Virginia, hopes that its new policy on sexual harassment will spur universities to deal more aggressively with the pervasive problem. But the additional reporting requirements, which will be officially published in the Federal Register, are far from a definitive statement about how NSF plans to deal with this complex and sensitive subject. [ScienceInsider] Editorial
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EVENTSNEW Gordon Research Conferences: Notch Signaling in Development, Regeneration and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Stem Cells, Development & Cancer (Albert Einstein College of Medicine) Postdoctoral Fellow – Immunology and iPSCs (Stanford University) Postdoctoral Associate – hiPSC-Based Brain Organoids (Rutgers University) Postdoctoral Fellow – Neurodegenerative Diseases (University of Alabama at Birmingham) Postdoctoral Associate – Induced Pluripotent Stem Cells (Duke University) Postdoctoral Fellow – Stem Cell Biology (City of Hope) Postdoctoral Position – Metabolic Regulation of Embryos and Stem Cells (Joslin Diabetes Center) Associate Scientific Editor – Cell Reports/Cell Stem Cell (Elsevier) Postdoctoral Position – Pancreas Development and Stem Cells (Helmholtz Zentrum München) Postdoctoral Fellowship – Neurodegeneration (Lund University) Research Scientist – Stem Cell Research (Evotec AG) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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