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Pulmonary Cell News| ESC & iPSC News 13.13 April 4, 2018 | |
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TOP STORYResearchers mapped the endogenous interactomes of Ezh2 and Suz12 in ESCs, and they combined this with a functional screen for H3K27 methylation marks. They found that Nsd1-mediated H3K36me2 co-locates with H3K27me2, and its loss leads to genome-wide expansion of H3K27me3. [Mol Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors showed that after release from pluripotency, a subpopulation of mouse ESC, kept in the naive state by 2i/LIF, expresses endothelial nitric oxide synthase (eNOS) and endogenously synthesizes NO. This eNOS/NO-positive subpopulation expressed mesendodermal markers and was more efficient in the generation of cardiovascular precursors than eNOS/NO-negative cells. [Nat Commun] Full Article Small Molecules Promote CRISPR-Cpf1-Mediated Genome Editing in Human Pluripotent Stem Cells Scientists demonstrated that the recently identified CRISPR-Cpf1 can be used to efficiently generate knockout and knockin human PSC (hPSC) lines. They developed an unbiased drug-selection-based platform feasible for high-throughput screening in hPSCs and this screening system enabled them to identify small molecules VE-822 and AZD-7762 that can promote CRISPR-Cpf1-mediated precise genome editing. [Nat Commun] Full Article Stem Cells Engineered during Different Stages of Reprogramming Reveal Varying Therapeutic Efficacies The authors explored the potential of creating induced pluripotent stem cell‐derived neural stem cells by using either unmodified or gene‐modified somatic cells and tested their fate and therapeutic efficacies in vitro and in vivo. [Stem Cells] Abstract Investigators generated c-Myc-free and non-integrating iPSCs from the urine cells of a spinal muscular atrophy patient using an episomal iPSC reprogramming vector and designed a unique crRNA that does not have similar sequences anywhere in the human reference genome. [Hum Gene Ther] Abstract The ability of label‐free quantitative coherent anti‐Stokes Raman scattering micro‐spectroscopy to identify populations of intermediate cell states during the differentiation of murine embryonic stem cells into adipocytes was assessed. [J Biophotonics] Abstract Researchers applied a bacterial type III secretion system-based protein delivery tool to directly translocate transcription factors in the form of protein into human PSCs (hPSCs). This transient protein delivery technique showed high delivery efficiency for hPSCs, and it avoids potential genetic alterations caused by the introduction of transgenes. [PLoS One] Full Article Investigators employed RNA-seq to undertake an in-depth analysis of transcriptome changes resulting from trisomy of chromosome 21, using iPSCs derived from a single individual with Down syndrome. [PLoS One] Full Article The functions of Poly (ADP-ribose) polymerase family, member 1 (Parp1) in intercellular signaling remain to be established. To examine the functions of Parp1 in intercellular signaling, scientists examined miRNA regulation in exosomes derived from Parp1-deficient embryonic stem cells. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSDisease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells The authors highlight recent advances in the 3D organoid technology for use in modeling complex hereditary diseases, cancer, host-microbe interactions, and possible use in translational and personalized medicine where organoid cultures were used to uncover diagnostic biomarkers for early disease detection via high throughput pharmaceutical screening. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSQ-State Biosciences and Vertex Pharmaceuticals Enter into Multi-Year Drug Discovery Collaboration Q-State Biosciences, Inc. announced that the company has entered into a strategic collaboration with Vertex Pharmaceuticals Incorporated to discover drugs using Q-State’s novel Optopatch™ platform. [Q-State Biosciences, Inc. (Business Wire, Inc.)] Press Release Transformational Gift Boosts Research to Generate Human Organs Scientists at Cincinnati Children’s have received an instrumental investment in their work to personalize medicine through organoid technology. The Farmer Family Foundation has pledged $5 million to advance this pioneering research, which is being conducted at Cincinnati Children’s Center for Stem Cell and Organoid Medicine. [Cincinnati Children’s Hospital Medical Center] Press Release The Human Frontier Science Program has announced the 2018 winners for the Research Grant applications – with a successful application by an MPI-CBG research group leader. Alf Honigmann has been awarded the highly prestigious and competitive Program Grant Award. [Max Planck Institute of Molecular Cell Biology and Genetics] Press Release | |
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POLICY NEWS2018 March for Science Will Be Far More than Street Protests The March for Science has matured. It may even have outgrown its name. [ScienceInsider] Editorial French Universities Cancel Subscriptions to Springer Journals French research organizations and universities have canceled their subscriptions to Springer journals, due to an impasse in fee negotiations between the publisher and Couperin.org, a national consortium representing more than 250 academic institutions in France. [The Scientist] Editorial EU Copyright Reforms Draw Fire from Scientists An influential committee of the European Parliament is due to vote on changes to copyright regulations in the European Union (EU), but the latest drafts of the rules have triggered a wave of criticism from open-science advocates. They say that the proposals will stifle research and scholarly communication. [Nature News] Editorial Cancer Researchers Push to Relax Rules for Clinical Trials US government examines whether criteria for participating in drug studies unnecessarily exclude some people. [Nature News] Editorial
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EVENTSNEW NSAS Course: Cell-Reprogramming Technology in Neuroscience Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.) NEW Senior Scientist – Stem Cells (VitroLabs Inc) Research Associate – Regulatory Dynamics and Cell Identity (Imperial College London) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Postdoctoral Fellow – Stem Cells, Development and Cancer (Albert Einstein College of Medicine) Postdoctoral Fellow – Immunology and iPSCs (Stanford University) Postdoctoral Associate – hiPSC-Based Brain Organoids (Rutgers University) Postdoctoral Associate – Induced Pluripotent Stem Cells (Duke University) Postdoctoral Fellow – Stem Cell Biology (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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