ESC & iPSC News 13.14 April 11, 2018 | |
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TOP STORYMechanism Vital to Keeping Blood Stem Cells Functional Uncovered Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function – and defective regulation of protein production is common in certain types of aggressive human blood cancers. Now, a research team at Lund University in Sweden has uncovered a completely new mechanism that controls how proteins are produced to direct stem cell function. [Press release from Lund University discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that the RNA binding protein HTATSF1 controls embryonic stem cell differentiation by regulating multiple aspects of RNA processing during ribosome biogenesis. HTATSF1-dependent protein synthesis was essential for naive pre-implantation epiblast to transition into post-implantation epiblast, a stage with transiently low protein synthesis, and further differentiation toward neuroectoderm. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency The authors report the development of an efficient two-step serum- and replating-free chemical induction of pluripotency protocol and the associated chromatin accessibility dynamics by assay for transposase-accessible chromatin-seq. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract Investigators present a cellular-state landscape for human PSC early differentiation that covers multiple cellular lineages, including neural, muscle, endothelial, stromal, liver, and epithelial cells. [Genome Biol] Full Article Simultaneous Reprogramming and Gene Editing of Human Fibroblasts Researchers describe a one-step protocol for reliable generation of clonally derived gene-edited iPSC lines from human fibroblasts in the absence of drug selection or FACS enrichment. [Nat Protoc] Abstract Scientists report that MYC rescues early human cells undergoing reprogramming from a proliferation pause induced by OCT3/4, SOX2, and KLF4 (OSK). They identified ESRG as a marker of early reprogramming cells that is expressed as early as day three after OSK induction. [Cell Rep] Full Article | Press Release | Graphical Abstract Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation The authors compared the success of chimera formation following injection of primary neural crest cells (NCCs) into blastocysts or of ESCs into E8.5 embryos (heterochronic injection) with that of injecting ESCs cells into the blastocyst or NCCs into the E8.5 embryos (isochronic injection). Chimera formation was efficient when donor and host were matched, but no functional chimeric contribution was found in heterochronic injections. [Stem Cell Reports] Full Article | Graphical Abstract To study the effects of short-term altered gravity on embryonic development processes, investigators exposed mouse ESCs to phases of hypergravity and microgravity and studied the differentiation potential of the cells using wide-genome microarray analysis. [Stem Cells Dev] Abstract To demonstrate the feasibility of the application of leukemia inhibitory factor (LIF) to marmoset iPSCs, scientists assessed these cells in the presence of LIF. The results showed that LIF significantly promoted the number of proliferating cells, but had no effect on apoptosis. [Int J Mol Med] Abstract | |
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REVIEWSHuman Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications The authors describe recent advances in methods for generating endodermal cell types from human pluripotent stem cells and their use for disease modeling and cell-based therapy. [Cell Stem Cell] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSAllele Receives Tissue Bank License for Manufacturing and Distribution of cGMP-Compliant iPSCs Allele Biotechnology & Pharmaceuticals Inc. has received a Tissue Bank License from the California Department of Public Health, making it the world’s first establishment to collect tissue for the manufacture and banking of iPSCs for commercial applications. [Allele Biotechnology & Pharmaceuticals Inc. (Business Wire, Inc.)] Press Release UMN Receives $42.6 Million to Expand Impact on Scientific Health Research The University of Minnesota’s Clinical and Translational Science Institute received more than $42 million in renewed National Institutes of Health funding through the National Center for Advancing Translational Sciences’ Clinical and Translational Science Award program. [University of Minnesota] Press Release | |
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POLICY NEWSSpanish Research Gets a Nice Budget Boost—but Scientists Say It Will Be of Little Help The Spanish government has announced plans to raise the country’s overall public R&D budget by 8.3% in 2018, from €6.5 billion to €7 billion—the biggest hike since the economic crisis hit Spain in 2008. [ScienceInsider] Editorial New Awards Aim to Celebrate Women in Science The two annual awards will recognize inspirational early-career female researchers and those who have worked to champion young women’s and girls’ participation in science. [Nature News] Editorial
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EVENTSNEW 3D Cell Culture 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESResearch Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.) Research Associate – Regulatory Dynamics and Cell Identity (Imperial College London) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Postdoctoral Fellow – Stem Cells, Development and Cancer (Albert Einstein College of Medicine) Postdoctoral Fellow – Immunology and iPSCs (Stanford University) Postdoctoral Associate – hiPSC-Based Brain Organoids (Rutgers University) Postdoctoral Associate – Induced Pluripotent Stem Cells (Duke University) Postdoctoral Fellow – Stem Cell Biology (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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