ESC & iPSC News 14.34 September 4, 2019 | |
| |
TOP STORYResearchers found that hypoxia-primed embryoid bodies efficiently differentiated into the myogenic lineage, resulting in the induction of the myogenic marker, MyoD, which was not mediated by HIF1α or HIF2α, but rather by Sp1 induction and binding to the MyoD promoter. [Mol Ther] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)APC as a Major Regulator of hESCs Self‐Renewal Scientists directly targeted adenomatous polyposis coli (APC) in human ESCs (hESCs) carrying a germline APC mutation, derived from affected blastocysts following preimplantation genetic diagnosis for familial adenomatous polyposis, in order to answer open questions regarding the role of APC in regulating pluripotency and differentiation potential of hESCs. [Stem Cells] Abstract The authors induced human embryonic stem (hES) cells to differentiate into dental epithelium using different concentrations of bone morphogenetic protein 4 (BMP4). With 1 pM BMP4, the hES cells differentiated into oral ectoderm. [Stem Cell Res Ther] Full Article Cardiac-derived mesenchymal progenitor cells, bone marrow-derived mesenchymal stem cells, and human dermal fibroblasts from the same patients were reprogrammed into iPSCs and differentiated into iPSC-derived cardiomyocytes. [Biochim Biophys Acta Mol Cell Res] Abstract Investigators developed a human iPSC line with a doxycycline-inducible expression system with the fusion gene ETV6-RUNX1 integrated into the genome. This is the most common genetic aberration found in childhood leukemia. [Stem Cell Res] Full Article To economically and efficiently produce cardiomyocytes from iPSCs through GCSFR/STAT axis activation, scientists constructed antibody/receptor chimeras that could respond to an inexpensive small molecule. [Biotechnol J] Abstract Investigators developed a 3D cell culture model for generating male germ cells from human iPSCs using a human decellularized amnion membrane scaffold. Human iPSCs were generated using retroviral vectors and characterized for pluripotency properties by immunofluorescence assay, flow cytometry, ALP staining, cytogenetic assay, and differentiation capacity. [Exp Cell Res] Abstract Researchers explored the effectiveness of decellularized amniotic membrane matrices for culturing of iPSCs and promoting their differentiation into hepatocyte‐like cells. [J Cell Biochem] Abstract Scientists used primary liver cells expanded from liver needle biopsies and reprogrammed them into liver derived iPSCs (Li-iPSCs) using a non-integrative Sendai virus-based system. Li-iPSCs were differentiated into hepatocyte-like cells using established differentiation protocols. [PLoS One] Full Article Subscribe to one of our other 19 science newsletters such as Cell Therapy News & Mesenchymal Cell News. | |
| |
REVIEWSThe Cell Cycle in Stem Cell Proliferation, Pluripotency and Differentiation The authors discuss the current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. [Nat Cell Biol] Abstract Scientists review the extant literature that has used iPSC-based modeling to understand the neuronal and glial contributions to neurodevelopmental disorders including autism spectrum disorder, Rett syndrome, bipolar disorder, and schizophrenia. [Mol Psychiatry] Abstract Pluripotent Stem Cell-Based Therapeutics for Muscular Dystrophies Researchers highlight the major research advances, challenges, and future prospects towards the development of PSC-based therapeutics for muscular dystrophies. [Trends Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
| |
INDUSTRY NEWSWoman Is First to Receive Cornea Made from ‘Reprogrammed’ Stem Cells A Japanese woman in her forties has become the first person in the world to have her cornea repaired using reprogrammed stem cells. [Nature News] Press Release Fate Therapeutics, Inc. announced that the FDA has cleared the company’s Investigational New Drug (IND) application for FT596, the company’s first off-the-shelf chimeric antigen receptor (CAR) natural killer (NK) cell cancer immunotherapy which targets multiple tumor-associated antigens. [Fate Therapeutics, Inc.] Press Release | |
| |
POLICY NEWSAs Hurricane Dorian Bears Down, Researchers Get Ready For the fourth consecutive year, scientists in Florida are preparing for a major hurricane, laying down sandbags and boarding up windows at research facilities along the state’s Atlantic coast. [ScienceInsider] Editorial Foreign Interference under the Spotlight at Australian Universities The Australian government says it will establish an expert committee to detect and respond to cyberattacks, intellectual-property theft and other strikes against universities by foreign governments or groups. The move comes amid growing concerns from some politicians and academics about foreign influence at Australian campuses. [Nature News] Editorial
| |
EVENTSNEW Precision Health: Molecular Basis, Technology and Digital Health Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Faculty Position – Stem Cell Biology (Children’s Research Institute at UT Southwestern) NEW Research Fellow – Vascular Stem Cell Biology (Queen’s University Belfast) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Postdoctoral Researcher – Cell Cycles in Stem Cells (University of California, Santa Cruz) Postdoctoral Positions – Stem Cell and Bioinformatics (Indiana University School of Medicine) Investigator – Stem Cells (GlaxoSmithKline) Assistant Specialist – Division of Cardiovascular Medicine (University of California, Davis) Biologist – Stem Cell Engineering (National Institute of Neurological Disorders and Stroke) Postdoctoral Fellow Positions – Cancer Research (Nationwide Children’s Hospital) Research Technician – Beta Cell Production from Human PSCs (Helmholtz Zentrum München) Postdoctoral Fellows – Striated Muscle Regeneration (Duke University) Postdoctoral Fellow – Genetics and Epigenomics of iPSC Biology (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in ESC & iPSC News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|