ESC & iPSC News 14.40 October 16, 2019 | |
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TOP STORYOrganoid Single-Cell Genomic Atlas Uncovers Human-Specific Features of Brain Development Researchers analyzed stem cell-derived cerebral organoids using single-cell transcriptomics and accessible chromatin profiling to investigate gene-regulatory changes that were specific to humans. Brain-region composition varied in organoids from different iPSC lines, but regional gene-expression patterns remained largely reproducible across individuals. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)After short-term exposure of iPSCs to GSK3i there was a significant change in cell morphology, primitive streak mesoderm markers were upregulated and markers of pluripotency were downregulated, both compared to the control group. [Theranostics] Full Article Scientists investigated the utility of a tailored poly(ethylene glycol) diacrylate-crosslinked porous polymeric tissue engineering scaffold, with mechanical properties specifically optimized to be comparable to that of mammalian brain tissue for three-dimensional human neural cell culture. [Acta Biomater] Abstract Investigators sequentially generated primitive streak, definitive endoderm, hepatoblasts and hepatocyte-like cells from human ESCs in different stages with completely defined reagents. [Cell Death Dis] Full Article The differentiation potential of iPSCs and mesenchymal stem cells into insulin producing cells was compared to each other while cultured on poly(lactic-co-glycolic) acid/polyethylene glycol nanofibrous scaffold as a 3D substrate and tissue culture polystyrene as a 2D substrate. [J Cell Physiol] Abstract CDK11 Safeguards the Identity of Human Embryonic Stem Cells via Fine-Tuning Signaling Pathways The authors report that CDK11, a member of the CDK family, was required for the maintenance of human (h) ESC self-renewal. The authors showed that, among the three main isoforms of CDK11, CDK11p46 was the main isoform safeguarding the hESC identity. [J Cell Physiol] Abstract From a human PSC line carrying an isochromosome 20, 56 single cells were analyzed and found to carry a total of 50 aberrations, across 23% of cells, which could not be detected by bulk analysis. [Sci Rep] Full Article By comparing the effects of two molecules on different cell types that may be considered to be non-relevant for Friedreich ataxia, such as fibroblasts, or more relevant to the disease, such as neurons differentiated from iPSCs, a differential response was observed. [Sci Rep] Full Article Transcriptomic Insight into Cadmium-Induced Neurotoxicity in Embryonic Neural Stem/Progenitor Cells In vitro experiments using cultured neural stem/progenitor cells verified that cadmium exposure reduced cell viability, proliferation, neurosphere formation and caused cell cycle arrest at low concentrations, while inducing cell apoptosis at high concentrations. [Toxicol In Vitro] Abstract Subscribe to one of our other 19 science newsletters such as Cell Therapy News & Mesenchymal Cell News. | |
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REVIEWSMany models of differentiation and modeling have relied on two-dimensional monocultures of specific cell types, which are not representative of the complexity of the human retina and optic nerve. Three-dimensional organoids and emerging cell culture methods may provide more physiologically relevant models to study developmental biology and pathology of the retina and optic nerve. [Curr Opin Pharmacol] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSReNeuron Shares Clinical Data on Stem Cell Vision Loss Therapy ReNeuron presented detailed data from a Phase I/IIa clinical trial of its stem cell treatment for retinitis pigmentosa. Shares in ReNeuron fell more than one-third after the release of top-line data at the start of the month, but the biotech argued the detailed results are positive for its prospects. [ReNeuron (FierceBiotech)] Press Release Medicine by Design is strengthening the University of Toronto as a global leader in regenerative medicine with a new investment of as much as $20 million in research that will accelerate stem cell and gene therapy, advance understanding of how the body repairs itself, and generate new technologies that will propel the field for decades. [Medicine by Design] Press Release | |
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POLICY NEWSRussian Authorities Seek to Ease Fears of a Scientist Going Rogue In a statement issued last week to Russian wire services, the health ministry here said it fully supports the World Health Organization position against making changes to the human germline – the genome of eggs, sperm, and embryos – that would be inherited by future generations “until its implications have been properly considered.” The ministry said it views any clinical use of genome-editing technologies on human embryos “premature.” [STAT News] Editorial German Lab Faces Criminal Charges after Undercover Investigation Charges have been lodged with a state prosecutor after the release of undercover video brought attention to the conditions under which animals are kept at the Laboratory of Pharmacology and Toxicology near Hamburg, The Guardian reported on October 15. [The Scientist] Editorial
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EVENTSNEW Keystone Symposia: Stromal Cells in Immunity and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scientist – Regenerative Medicine (Cedars-Sinai Medical Center) PhD Position – Human Inducible Stem Cells (University of Fribourg) Postdoctoral Position – Nuclear RNA Decay and Stem Cell Differentiation (Aarhus University) Research Associate – Computational Image Analysis and AI (University of Bristol) Research Associate – Human IPSC Culture (Bayer) Group Leader – Stem Cell Science (University of Cambridge) Faculty Position – Stem Cell Biology (Children’s Research Institute at UT Southwestern) Postdoctoral Positions – Stem Cell and Bioinformatics (Indiana University School of Medicine) Assistant Specialist – Division of Cardiovascular Medicine (University of California, Davis) Postdoctoral Fellows – Striated Muscle Regeneration (Duke University) Postdoctoral Fellow – Genetics and Epigenomics of iPSC Biology (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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