ESC & iPSC News 14.47 December 4, 2019 | |
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TOP STORYNeuronal Impact of Patient-Specific Aberrant NRXN1α Splicing Scientists established that human induced pluripotent stem cell (hiPSC)-derived neurons well represented the diversity of NRXN1α alternative splicing observed in the human brain, cataloguing 123 high-confidence in-frame human NRXN1α isoforms. [Nat Genet] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists demonstrated that the induction of mesoderm and definitive endoderm (ME) gene programs critically relied on the T-box transcription factors Eomesodermin (also known as Eomes) and Brachyury, which concomitantly repressed pluripotency and neuroectoderm gene programs. [Nat Cell Biol] Abstract Investigators demonstrated the utility of the exc+/int− transposase in cassette removal for the generation of reprogramming factor-free induced PSCs. [Nucleic Acids Res] Full Article Researchers transplanted microglial precursors derived in vitro from human iPSCs into neonatal mouse brains and found that the cells acquired characteristic microglial morphology and gene expression signatures that closely resembled primary human microglia. [Proc Natl Acad Sci USA] Abstract The authors found that OCT4 and SOX2 operated in a largely independent manner even at co-occupied sites, and that their cooperative binding was mostly mediated indirectly through regulation of chromatin accessibility. [eLife] Full Article Scientists used human iPSC-derived astrocytes from amyotrophic lateral sclerosis (ALS) patients carrying C9orf72 mutations and non-affected donors. They utilized these cells to investigate astrocytic induced neuronal toxicity, changes in astrocyte transcription profile as well as changes in secretome profiles. [EBioMedicine] Full Article Overexpression of miR-10b promoted cardiomyocyte (CM) proliferation, while knockdown of miR-10b suppressed CM proliferation. [Mol Ther Nucleic Acids] Abstract | Full Article Investigators found that linc1557 was highly expressed in mouse ESCs and required for the initiation of ESC differentiation. Knockdown of linc1557 increased the expression and phosphorylation levels of STAT3, a key factor in the LIF/STAT3 signaling pathway. [Stem Cells] Abstract Graft Immaturity and Safety Concerns in Transplanted Human Kidney Organoids Scientists purified kidney organoids and transplanted them beneath the kidney capsules of immunodeficient mice to test their safety and maturity. Kidney organoid grafts survived for months after transplantation and became vascularized from host mouse endothelial cells. [Exp Mol Med] Full Article Co-cultures of the interneurons with excitatory cortical pyramidal neurons from schizophrenia iPSCs showed reduced synaptic puncta density and lower action potential frequency. NLGN2 overexpression in schizophrenia neurons rescued synaptic puncta deficits while NLGN2 knockdown in healthy neurons resulted in reduced synaptic puncta density. [Transl Psychiatry] Full Article Researchers showed the link between changes in cell identity with the regulation of integrin α5 expression through the alteration of early stages of mesoderm commitment. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Cell Therapy News & Mesenchymal Cell News. | |
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REVIEWSOrganoids – New Models for Host–Helminth Interactions The authors discuss the applicability of organoid technology to helminth infection research, including strategies of co-culture of helminths or their products with organoids and the challenges, advantages, and drawbacks of the use of organoids for these studies. [Trends Parasitol] Abstract Recapitulating Human Tissue Damage, Repair and Fibrosis with hPSC-Derived Organoids: Concise Review Recent studies have shown that organoid tissue injury recapitulates major events and histopathological features of damaged human tissues. In particular, major mechanisms of parenchyma cell damage and interstitial fibrosis can be reproduced with remarkable faithfulness. [Stem Cells] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSStemoniX, Inc. and Atomwise Inc. announced a joint venture that combines StemoniX’s human microOrgan® platform with Atomwise’s AI technology to enable the rapid discovery and development of novel small molecule therapies. [StemoniX, Inc. (PR Newswire Association LLC)] Press Release The National Stem Cell Foundation announced that research teams from Aspen Neuroscience and the New York Stem Cell Foundation Research Institute will send a first-in-kind study of neurodegenerative disease to the International Space Station. [The National Stem Cell Foundation] Press Release | |
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POLICY NEWSCrack Down on Genomic Surveillance Concerns about the potential downsides of governments being able to interrogate people’s DNA have been voiced since the early 2000s1 by activist groups, such as the non-profit organization GeneWatch UK, and some geneticists. [Nature News] Editorial Elsevier Progresses in Open-Access Deal Making The scholarly publisher has announced several new licensing agreements in both Europe and the US, but some major academic groups are still without contracts and access to journals. [The Scientist] Editorial
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EVENTSNEW FGF Signaling: Understanding Function and Devising Therapeutic Tools Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow Positions – Cardiac iPSCs (Stanford Cardiovascular Institute) Postdoctoral Fellow – iPSC Heart Cells (Stanford University) Research Techician – iPSC Culture Lab (University of Luxembourg) Postdoctoral Associate – Stem Cell Research (University of Minnesota Twin Cities) Faculty Position – Stem Cell Research (Yale University School of Medicine) Multiple Positions – Stem Cell Biology (NIH NCATS Stem Cell Translation Laboratory) Research Assistant – Stem Cells and Engineering (New York Blood Center) Postdoctoral Researcher – CRISPR/Cas9 in ESCs (Institute of Molecular Biology GmbH) Postdoctoral Researcher – iPSC Models in Neurology (IRIBHM) Postdoctoral Scientist – Regenerative Medicine (Cedars-Sinai Medical Center) PhD Position – Human Inducible Stem Cells (University of Fribourg) Assistant Specialist – Division of Cardiovascular Medicine (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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