ESC & iPSC News 15.01 January 15, 2020 | |
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TOP STORYMaternal Factor NELFA Drives a 2C-Like State in Mouse Embryonic Stem Cells Researchers identified a maternal factor – negative elongation factor A (NELFA) – whose heterogeneous expression in mouse ESCs was coupled to 2C gene upregulation and expanded developmental potential in vivo. [Nat Cell Biol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)On-Chip 3D Neuromuscular Model for Drug Screening and Precision Medicine in Neuromuscular Disease Scientists describe the design, fabrication and use of a 3D physiological and pathophysiological motor unit model consisting of motor neurons coupled to skeletal muscles interacting via the neuromuscular junction within a microfluidic device. [Nat Protoc] Abstract Generation of Mesenchyme Free Intestinal Organoids from Human Induced Pluripotent Stem Cells The authors report a directed differentiation protocol for the generation of mesenchyme-free human intenstinal organoids that could be primed towards more colonic or proximal intestinal lineages in serum-free defined conditions. [Nat Commun] Full Article Genetic Aberrations in iPSCs Are Introduced by a Transient G1/S Cell Cycle Checkpoint Deficiency Investigators describe efficient generation of human integration-free iPSCs using erythroblast cells, which had only a small number of point mutations and INDELs, none of which were in coding regions. [Nat Commun] Full Article Researchers successfully recapitulated early kidney tissue patterning events, exploring more than 1000 unique conditions in an unbiased and quantitative manner, and defined new media combinations that achieved near-pure renal cell type specification. [Sci Adv] Full Article Scientists uncovered a molecular relationship between p53, an abundant embryonic transcription factor, and WDR5, an essential member of the MLL chromatin modifying complex, that regulated mouse ESC fate. [Cell Rep] Full Article | Graphical Abstract DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation DDX18 bound and sequestered polycomb repressive complex 2 (PRC2) in the outer layer of the nucleolus and counteracted PRC2 complex formation in vivo and in vitro. [Cell Rep] Full Article | Graphical Abstract Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture Investigators describe the formulation of a human iPSC culture medium as a result of the exhaustive optimization of medium constituents and concentrations, establishing the necessity and relative contributions of each component to the pluripotent state and cell proliferation. [Stem Cell Reports] Full Article Modeling the Pathogenesis of X-Linked Distal Hereditary Motor Neuropathy Using Patient-Derived iPSCs Researchers generated iPSC-derived motor neurons from a patient with the p.T994I ATP7A gene mutation as an in vitro model for X-linked distal hereditary motor neuropathy. [Dis Model Mech] Full Article Subscribe to one of our other 19 science newsletters such as Cell Therapy News & Mesenchymal Cell News. | |
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REVIEWSRopinirole, a New ALS Drug Candidate Developed Using iPSCs The authors review the preclinical data, clinical research design, and rationale for ropinirole as an anti-amyotrophic lateral sclerosis (ALS) drug candidate compared with those of two other drugs. [Trends Pharmacol Sci] Full Article Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSAstellas Pharma, Inc. and Adaptimmune Therapeutics plc announced that they have entered into a co-development and co-commercialization agreement to bring new stem-cell derived allogeneic T-cell therapies to people with cancer. [Astellas Pharma, Inc.] Press Release ISSCR Announces 2020 Award Winners Stem cell scientists and leaders have earned 2020 International Society for Stem Cell Research (ISSCR) Awards for their significant contributions to the field of stem cell research. Honorees will be recognized at the ISSCR 2020 Annual Meeting in Boston. [International Society for Stem Cell Research] Press Release | |
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POLICY NEWSFDA and NIH Let Clinical Trial Sponsors Keep Results Secret, Investigation Shows For 20 years, the US government has urged companies, universities, and other institutions that conduct clinical trials to record their results in a federal database, so doctors and patients can see whether new treatments are safe and effective. [STAT News] Editorial Protect India’s Universities For several weeks the world has watched as India’s citizens – including academics and students – have taken to the streets. Tens of thousands have been gathering to read out the preamble to the Indian constitution, as a mark of protest against a discriminatory new citizenship law. [Nature News] Editorial
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EVENTSNEW Keystone Symposia: Hematopoiesis Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Position – Human Inducible Stem Cells (University of Fribourg) NEW Postdoctoral Positions – Stem Cell Biology (Albert Einstein College of Medicine) Postdoctoral Training Fellow – Drosophila Genetics (The Francis Crick Institute) Postdoctoral Fellow – Stem Cell Research (Georgetown University Medical Center) Postdoctoral Research Fellow – Endocrinology (Cedars-Sinai Medical Center) Scientist – Stem Cell Biology (Genentech, Inc.) Postdoctoral Fellowship – Organ Progenitor Fate (University of Copenhagen) Postdoctoral Fellow Positions – Cardiac iPSCs (Stanford Cardiovascular Institute) Postdoctoral Fellow – iPSC Heart Cells (Stanford University) Assistant Specialist – Division of Cardiovascular Medicine (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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