ESC & iPSC News 15.09 March 11, 2020 | |
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TOP STORYMutations in enzymes that modify histone H3 at lysine 4 (H3K4) or lysine 36 (H3K36) have been linked to human disease, yet the role of these residues in mammals is unclear. The authors mutated K4 or K36 to alanine in the histone variant H3.3 and showed that the K4A mutation in mouse ESCs impaired differentiation and induced widespread gene expression changes. [Nat Genet] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators report that the functionality of vascular progenitors generated from normal and disease-primed conventional human iPSCs could be significantly improved by reversion to a tankyrase inhibitor-regulated human naïve epiblast-like pluripotent state. [Nat Commun] Full Article Polycomb Regulation Is Coupled to Cell Cycle Transition in Pluripotent Stem Cells Scientists found that polycomb repressive complex 2 subunits were differentially recruited to lineage specifier gene promoters across cell cycle in mouse ESCs. [Sci Adv] Full Article MicroRNAs Organize Intrinsic Variation into Stem Cell States Researchers found that ESCs exhibited intrinsic heterogeneity in the absence of external gradients by forming interconverting cell states. States varied in developmental gene expression programs and displayed distinct activity of miRNAs. [Proc Natl Acad Sci USA] Full Article Investigators describe the generation and molecular characterization of human iPSC-derived retinal sheets from controls, and Meckel-Gruber and Bardet-Biedl cases. [Stem Cell Reports] Full Article | Graphical Abstract The authors demonstrated that the long non-coding RNA (lncRNA) 5430416N02Rik gene locus maintained the fast proliferation of ESCs by activating the expression of Mid1 through chromatin interaction. [Stem Cell Reports] Full Article Scientists report the generation of two iPSC-lines from patients with radiographic hand osteoarthritis. [Sci Rep] Full Article Transplantation of a 3D-Printed Tracheal Graft Combined with IPS Cell-Derived MSCs and Chondrocytes Investigators designed an artificial trachea with mechanical properties similar to native trachea that could enhance the regeneration of tracheal mucosa and cartilage through the optimal combination of a two-layered tubular scaffold and human iPS-derived cells. [Sci Rep] Full Article Researchers demonstrated that Daxx knockout promoted the expression of rDNA, pluripotency, and neurodevelopment genes. [Cell Reprogram] Abstract Subscribe to one of our other 19 science newsletters such as Cell Therapy News & Mesenchymal Cell News. | |
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REVIEWSMulti-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery The authors discuss recent advances in generating more complex human iPSC-based systems using 3D organoids, tissue-engineering, microfluidic organ-chips, and humanized animal systems. [Cell Stem Cell] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSNanoSurface Bio Executes Exclusive License of Heart-on-Chip Technology Launched into Space NanoSurface Biomedical announced that it has executed an exclusive IP license agreement related to innovative heart-on-chip technology developed by researchers at the University of Washington. An experimental system built from the same heart-on-chip technology was launched into space aboard SpaceX’s 20th resupply mission to the International Space Station as part of the Tissue Chips in Space initiative conducted in partnership between the National Center for Advancing Translational Sciences and the ISS US National Laboratory. [NanoSurface Biomedical] Press Release Century Therapeutics Announces Opening of Seattle Innovation Hub Century Therapeutics announced the opening of its Seattle-based Innovation Hub to develop next-generation product candidates that overcome barriers that have limited the effectiveness of cell therapies in solid tumor cancers. [Century Therapeutics (Business Wire, Inc.)] Press Release | |
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POLICY NEWSHundreds of Scientists Have Peer-Reviewed for Predatory Journals Hundreds of scientists who post their peer-review activity on the website Publons say they’ve reviewed papers for journals termed ‘predatory’, an analysis has found. The site hosts at least 6,000 records of reviews for more than 1,000 predatory journals. [Nature News] Editorial New Trump Rules Aim to Fuel Sharing of Patient Health Records by Smartphone President Trump’s top health care aides said they will finalize federal rules requiring health providers and insurers to make health records available to patients in an easily accessible electronic format, a policy shift aimed at fueling broader efforts to use patient data to develop new software tools and services. [STAT News] Editorial
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EVENTSNEW Tissue Engineering and Regenerative Medicine Asia-Pacific Conference 2020 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Specialist – Stem Cells for Regenerative Medicine (University of Illinois at Chicago) Head – Automated Stem Cell and Organoid Facility (Fondazione Human Technopole) Postdoctoral Scholarship – Non-Coding RNAs (University of Gothenburg) Postdoctoral Associate – Cerebral Organoids (Weill Cornell Medicine) Postdoctoral Fellowship – Stem Cell Niche Biology (University of California, San Francisco) Postdoctoral Positions – Create ‘Foie Gras’ in Vitro from Stem Cells (KU Leuven) PhD Position – Human Inducible Stem Cells (University of Fribourg) Assistant Specialist – Division of Cardiovascular Medicine (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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