| Vol. 15.23 – 17 June, 2020 |
| |
|
|
| The authors showed that human ESCs could be used to generate gastruloids—three-dimensional multicellular aggregates that differentiate to form derivatives of the three germ layers organized spatiotemporally, without additional extra-embryonic tissues. [Nature] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators used a combination of patient-derived human iPSCs, Shank3Δ11(−/−) mice, and Phelan-McDermid syndrome muscle biopsies from patients of different ages to analyze the role of SHANK3 on motor unit development. [Science Translational Medicine] |
|
|
|
| Intravenous delivery of immunity- and matrix-regulatory cells, derived from human ESCs, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms. [Cell Research] |
|
|
|
| Using intracellular biopsy technique (inCell-Biopsy), scientists analyzed the temporal miRNA transcriptome over the differentiation of ESCs. The combinatorial miRNA expression patterns derived by inCell-Biopsy identified emerging cell subpopulations differentiated from ESCs and revealed the dynamic evolution of cellular heterogeneity. [Science Advances] |
|
|
|
| Researchers established a humanized transplantation model of Parkinson’s disease that better recapitulates the main disease features, obtained by coinjection of preformed human α-synuclein (α-syn) fibrils and adeno-associated virus expressing human wild-type α-syn unilaterally into the rat substantia nigra. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Scientists generated a conditional knockout of NAT1 in PSCs and used the cells for the functional analyses of NAT1. Their results showed that NAT1 was required for the self-renewal and neural differentiation of primed PSCs. [Cell Reports] |
|
|
|
| The authors focused on a well-established differentiation process to cerebral cortex neural progenitor cells and their neuronal progeny from human PSCs. [Cell Reports] |
|
|
|
| Researchers applied a modified derivation method to the PSC line and first obtained human somatic cell nuclear transfer-PSC lines derived from both donated cryopreserved oocytes and cord blood cells with a homozygous human leukocyte antigen type. [Stem Cell Reports] |
|
|
|
| Investigators differentiated human induced PSCs into insulin-producing cells in a stepwise process that recapitulated pancreas organogenesis and observed that miR-181c-5p continuously accumulated throughout the entire differentiation process. [Cell Death & Disease] |
|
|
|
| Mononuclear cells separated from the peripheral blood of O D-positive and rare blood type donors were cultured to produce and expand erythroid progenitors and reprogrammed into iPSCs. A 31-day serum-free, xeno-free erythroid differentiation protocol was used to generate reticulocytes. [Journal of Translational Medicine] |
|
|
|
| Neurons were individually induced, facilitating the regulation of the beating rates of hiPSC-derived cardiomyocytes in an antagonistic manner. [Scientific Reports] |
|
|
|
| Investigators profiled R-loops during somatic cell reprogramming and found that dynamic changes in R-loops were essential for reprogramming and occurred before changes in gene expression. [Genetics] |
|
|
|
| In dog and human, the authors describe a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits. [Molecular Therapy-Methods & Clinical Development] |
|
|
|
|
| Approaches for whole-tooth regeneration utilizing adult stem cells, iPSCs, or tooth germ cells transplantation are emerging as promising alternatives to overcome existing in vitro tissue generation hurdles. The authors discuss the most recent advances in cellular signaling guiding dental tissue genesis. [International Journal of Molecular Sciences] |
|
|
|
|
| AgeX Therapeutics, Inc. and Pluristyx, Inc. have announced they have entered into a manufacturing, marketing, and distribution agreement through which Pluristyx will undertake these activities on behalf of AgeX with respect to AgeX’s research- and clinical-grade ESI brand human ESCs. [AgeX Therapeutics Inc.] |
|
|
|
| The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022. [ScienceInsider] |
|
|
|
|
| 2020-09-08 – 2020-09-11 Virtual | |
|
|
|
|
|
| Genentech – South San Francisco, California, United States |
|
|
|
| University of California – San Francisco, California, United States |
|
|
|
| Henry Ford Health System – Detroit, Michigan, United States |
|
|
|
| Wellcome Sanger Institute – Cambridge, United Kingdom |
|
|
|
| Spanish National Center for Cardiovascular Research – Madrid, Spain |
|
|
|
| Century Therapeutics – Philadelphia, Pennsylvania, United States |
|
|
|
| Evotec SE – Hamburg, Germany |
|
|
|
| Center for Biologics Evaluation and Research – Silver Spring, Maryland, United States |
|
|
|
| The Jackson Laboratory – Ben Harbor, Maine, United States |
|
|
|
| Albert Einstein College of Medicine – New York, New York, United States |
|
|
|
| University of Illinois at Chicago – Chicago, Illinois, United States |
|
|
|
| Empyrean Therapeutics Ltd – Cambridge, United Kingdom |
|
|
|
| Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
|
|
|
|