 | | Vol. 15.24 – 24 June, 2020 |
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| Differentiation assays revealed that developmental pluripotency associated 2 and 4 (Dppa2/4) double knockout mouse ESCs failed to exit pluripotency and differentiate efficiently.
[Nature Structural & Molecular Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers provided novel insights into understanding the functions of Brpf3 in proper differentiation as well as cell-cycle progression of ESCs via regulation of Myst2 stability by obstructing Huwe1-mediated ubiquitination.
[Cell Death & Differentiation] |
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| Scientists generated human iPSC-derived neurons exhibiting spontaneous oscillatory activity after cultivation of up to six months, which resembled early oscillations observed in rodent neurons. This behavior was found in neurons generated using a more “native” embryoid body protocol, in contrast to a “fast” protocol based on NGN2 overexpression.
[Stem Cell Reports] |
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| The authors examined the effect of mutations in 703 genes from nearly 70 chromatin-modifying complexes on human ESC growth. While the vast majority of chromatin-associated complexes were essential for ESC growth, the only complexes that conferred growth advantage upon mutation of their members, were the repressive complexes LSD-CoREST and BHC.
[Stem Cell Reports] |
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| Electrophysiological whole-cell voltage- and current-clamp recordings were performed on two control and three fragile X syndrome patient lines of human cortical neurons derived from iPSCs.
[Molecular Autism] |
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| Investigators provided the first research finding on a venom-based peptide that works on the FGF and TGF-β signaling pathways to maintain the self-renewal of human ESCs.
[Stem Cell Research & Therapy] |
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| Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports] |
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| Scientists demonstrated that goat putative ESCs were successfully in vitro differentiated into primordial germ cells and oocyte-like cells using bone morphogenetic protein-4 and trans-retinoic acid.
[Scientific Reports] |
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| Investigators demonstrated that an adeno-associated viruses-coupled CRISPR/Cas9 system was able to target and correct Forkhead Box G1 (FOXG1) variants in patient-derived fibroblasts, iPSCs and iPSC-derived neurons.
[European Journal of Human Genetics] |
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| The authors report an electroporation-mediated plasmid CRISPR/Cas9 delivery approach for genome editing in iPSCs. With this approach, an edited iPSC cell line could be obtained within two weeks.
[Acta Pharmacologica Sinica] |
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| Researchers successfully converted three in-house-derived primed human PSC lines (H10, H24, and iPS) to a naive state and an expanded PSC (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[PLoS One] |
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| The authors highlight the current sources for natural killer (NK) therapies and their respective constraints, discuss recent developments in the manufacturing and genetic engineering of iPSC-NK cells, and provide an overview of ongoing clinical trials using NK cells.
[Stem Cell Research & Therapy] |
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| Century Therapeutics has announced its acquisition of Empirica Therapeutics to leverage its iPSC-derived allogeneic cell therapies against glioblastoma.
[Businesswire (Century Therapeutics)] |
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| With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News] |
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| 2020-07-09 – 2020-07-09
Virtual |
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| | The Babraham Institute – Cambridge, United Kingdom |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Sup’Biotech Engineering School – Villejuif, Lyon, France |
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| | Genentech – South San Francisco, California, United States |
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| | Henry Ford Health System – Detroit, Michigan, United States |
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