 | | Vol. 15.26 – 15 July, 2020 |
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| The authors report ARID1A, a DNA-binding subunit of the SWI/SNF epigenetic complex, controlled both neurogenesis and cardiogenesis from human embryonic stem cells through distinct mechanisms.
[Genome Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators describe an in vitro platform that modeled features of human type 1 diabetes using stress-induced patient-derived endocrine cells and autologous immune cells.
[Cell Reports] |
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| To gain insight how the metabolic fluxes in pluripotent stem cells could be influenced by inactivating mutations in epigenetic enzymes, the authors generated human embryonic stem cells deficient for de novo DNA methyltransferases 3A and 3B.
[Stem Cells] |
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| Researchers found that Rad50 was highly expressed in pluripotent stem cells and that Rad50 regulated global DNA demethylation levels.
[Experimental and Molecular Medicine] |
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| Investigators report that the commonly used EF1α promoter was silenced in induced pluripotent stem cells, and that the endogenous promoter of the PPP1R12C gene was not strong enough to drive high levels of inducible caspase‐9 expression.
[Stem Cells Translational Medicine] |
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| Researchers analysed whether prolonged activation of Ca2+-activated potassium channels by zoxazolamine induces differentiation of mouse embryonic stem cells towards cardiomyocytes.
[Biochimica Et Biophysica Acta-Molecular Cell Research] |
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| The loss of C-terminal binding protein 1/2 Ctbp1/2 impaired the PRDM14-mediated transcriptional repression required for pluripotency maintenance and transition from primed to naïve pluripotency.
[Journal of Cell Science] |
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| Scientists assessed the capabilities of an open access device to support cardiac myocytes derived from human iPSCs, confirming that cells cultured under electromechanical stimulation presented a defined/mature cardiomyocyte phenotype.
[Scientific Reports] |
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| The authors discuss recent progress in understanding how interneuron subtypes are generated in vivo, and how that progress is being applied to the generation of rodent and human cortical interneurons in vitro.
[Stem Cells] |
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| Fate Therapeutics, Inc. announced that the FDA has cleared the company’s Investigational New Drug application for FT819, an off-the-shelf allogeneic chimeric antigen receptor T-cell therapy targeting CD19+ malignancies.
[Fate Therapeutics, Inc.] |
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| Lineage Cell Therapeutics, Inc. provided an update on OPC1, the company’s oligodendrocyte progenitor cell therapy for the treatment of acute spinal cord injury.
[Lineage Cell Therapeutics, Inc.] |
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| To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group.
[Science Insider] |
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| October 20 – October 21
Virtual |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Wellcome Sanger Institute – Cambridge, United Kingdom |
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| | University of Connecticut Health – Farmington, Connecticut, United States |
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| | The Babraham Institute – Cambridge, United Kingdom |
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| | Northwestern University – Chicago, Illinois, United States |
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