 | | Vol. 15.27 – 22 July, 2020 |
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| The authors showed that resetting from primed to naïve human pluripotency resulted in acquisition of a DNA methylation landscape mirroring the cancer DNA methylome, with gradual hypermethylation of bivalent developmental genes.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that β-catenin, stabilized by GSK3 inhibition in medium with 2i, supplied transcriptional coregulators at pluripotency loci. This selectively strengthened pluripotency loci and rendered them addicted to transcription initiation for productive gene body elongation in detriment to promoter-proximal paused RNA polymerase II pause release.
[Science Advances] |
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| Scientists analyzed whether defects in DNA replication contributed to genomic instability and the diverse differentiation potentials of reprogrammed pluripotent stem cells.
[Journal of Cell Biology] |
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| Researchers investigated whether combined modulation of BMP, FGF, and RA signaling pathways could enrich the differentiation of sinoatrial node-like cells from human pluripotent stem cells.
[Stem Cell Research & Therapy] |
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| To understand the mechanisms of disturbed differentiation and development by radiation, murine CGR8 embryonic stem cells were exposed to ionizing radiation and differentiated by forming embryoid bodies.
[Cells] |
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| Scientists generated combinations of Tet knockout embryonic stem cells and systematically measured protein and DNA modification levels at the transition from naive to primed pluripotency.
[Scientific Reports] |
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| Investigators identified the reference genes best suited for experiments that induce osteogenic differentiation from human induced pluripotent stem cells.
[Scientific Reports] |
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| How rapamycin affects cardiomyocyte differentiation of induced pluripotent stem cells is still not fully understood. The authors investigated the effect of rapamycin on cardiomyocyte differentiation based on the embryoid body method.
[Stem Cells and Development] |
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| Researchers demonstrated interfacing of cardiomyocytes derived from human induced pluripotent stem cells, which were engineered to express Channelrhodopsin-2.
[npj Flexible Electronics] |
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| The authors summarize the latest advances in the understanding of PI3K/AKT/SOX2-driven stemness and its intertwined relations to p53-signaling in DNA damage response under conditions of pluripotency, reprogramming, and transformation.
[International Journal of Molecular Sciences] |
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| Scientists summarize the updated knowledge, perspectives, and limitations of pluripotent stem cell-derived cardiomyocytes for heart regeneration.
[Journal of Cardiology] |
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| Notch Therapeutics Inc. announced the appointment of David Main as President and Chief Executive Officer.
[Notch Therapeutics Inc.] |
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| A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News] |
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| August 27 – August 29
Virtual |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Wellcome Sanger Institute – Cambridge, United Kingdom |
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| | University of Connecticut Health – Farmington, Connecticut, United States |
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| | The Babraham Institute – Cambridge, United Kingdom |
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| | Northwestern University – Chicago, Illinois, United States |
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