 | | Vol. 15.28 – 29 July, 2020 |
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| The authors showed that core pluripotency factors OCT4 and SOX2 suppress chaperone-mediated autophagy, a selective form of autophagy, until the initiation of differentiation.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report directed self-organization of human iPSCs in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
[Nature Communications] |
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| Scientists describe a method for rapid, consistent, and highly efficient generation of human iPSC–derived endothelial cells. The protocol entailed the delivery of modified mRNA encoding the transcription factor ETV2 at the intermediate mesodermal stage of differentiation.
[Science Advances] |
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| The authors found that the paired‐less PAX 6, PAX 6D, was expressed in neural retina cells during human eye development and along human embryonic stem cell specification to retinal cells.
[EMBO Reports] |
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| Following the establishment of an inducible Dux transgenic mouse model, investigators demonstrated that transient overexpression of Dux not only improves somatic cell nuclear transfer efficiency but also increased that of chemically iPSC reprogramming.
[EMBO Reports] |
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| Using CYP4V2 mutant PSCs as disease models, scientists demonstrated that retinal pigmented epithelial cells with CYP4V2 mutations presented a disrupted fatty acid homeostasis, which were characterized with excessive accumulation of poly-unsaturated fatty acid.
[Molecular Therapy] |
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| Leukemia inhibitory factor (LIF) is a cytokine essential for maintaining pluripotency of mouse ESCs. Scientists found that LIF was present in the intestinal stem cell (ISC) niche in crypts and critical for the function of ISCs in maintaining the intestinal epithelial homeostasis and regeneration.
[Cell Death & Disease] |
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| Researchers used channelrhodopsin-2 transfected mouse ESC-derived motor neurons to explore short and long-term programming of neural networks by using optical stimulation implemented during neurogenesis and synaptogenesis.
[Scientific Reports] |
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| Investigators established the induction protocol of immunosuppressive cells from common marmoset ESCs. Although similar immunosuppressive macrophages could not be induced by same protocol as that for mouse pluripotent stem cells, they employed an inhibitor for histone methyltransferase, DZNep, and succeeded to induce them.
[Scientific Reports] |
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| Researchers used targeted gene editing to introduce the inducible Caspase-9 system into human iPSCs, and then interrogated the efficiency of inducible apoptosis with normal iPSCs as well as diseased iPSCs derived from patients with acute myeloid leukemia.
[Gene Therapy] |
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| The authors summarize the updated knowledge, perspectives, and limitations of PSC-derived cardiomyocytes for heart regeneration.
[Journal of Cardiology] |
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| Scientists describe the characteristics of natural killer (NK) cells from multiple cell sources, including PSCs, the chimeric antigen receptor-modification method and strategy for these NK cells.
[International Journal of Hematology] |
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| As deaths from COVID-19 approach 150,000 in the United States and cases continue to rise alarmingly in many regions of the country, there are strong signs that the government is suppressing a public-health approach to controlling the pandemic.
[Nature News] |
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| As soon as the first COVID-19 vaccines get approved, a staggering global need will confront limited supplies. Many health experts say it’s clear who should get the first shots: health care workers around the world, then people at a higher risk of severe disease, then those in areas where the disease is spreading rapidly, and finally, the rest of us.
[ScienceInsider] |
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| Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist] |
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| February 28 – March 3 2021
Schöntal Monastery, Germany |
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| | Institute of Molecular Biology – Mainz, Germany |
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| | Oklahoma Medical Research Foundation (OMRF) – Oklahoma City, Oklahoma, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | University of Connecticut Health – Farmington, Connecticut, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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