 | | Vol. 15.30 – 12 August, 2020 |
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| Scientists used metabolic labeling with stable isotopes and mass spectrometry to quantitatively address the global turnover of genomic 5-methyl-2′-deoxycytidine, 5-hydroxymethyl-2′-deoxycytidine and 5-formyl-2′-deoxycytidine across mouse pluripotent cell states.
[Nature Chemical Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated a high-throughput 3D culture platform used to systematically screen 1200 culture conditions with varying doses, durations, dynamics, and combinations of signaling cues to derive oligodendrocyte progenitor cells and midbrain dopaminergic neurons from human PSCs.
[Science Advances] |
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| Investigators describe a medulloblastoma model using iPSC-derived human neuroepithelial stem cells generated from a Gorlin syndrome patient carrying a germline mutation in the sonic hedgehog receptor PTCH1.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers showed that the miR-290-PFN2 pathway regulates many aspects of ESC biology. In the absence of miRNAs, PFN2 was up-regulated in ESCs, with a resulting decrease in endocytosis.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors report that mouse ESCs with Wnt3a-bead induction displayed nonoverlapping preexisting (old) versus newly synthesized (new) histone H3 patterns, but mouse ESCs without Wnt3a beads had largely overlapping patterns.
[Cell Reports] |
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| To gain new insights into aberrant Down syndrome (DS) development during early stages of mesoderm formation and its possible connection to lower solid tumor prevalence, the authors developed the first model of two types of DS iPSC-derived stromal cells.
[Scientific Reports] |
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| Researchers demonstrated developmental differences in gene expression and accessible chromatin between progenitors and Müller glia (MG), primarily in neurogenic genes. Overexpression of Ascl1 was more effective in reprogramming immature MG, than mature MG, consistent with a more progenitor-like epigenetic landscape in the former.
[Scientific Reports] |
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| The authors present a scalable nano-warming technology for human iPSC cryopreservation employing inductive heating of magnetic nanoparticles under an alternating magnetic field.
[Scientific Reports] |
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| Investigators generated human ESC-derived otic neuronal progenitor spheroids—an aggregate form conducive to differentiation, transplantation, and prolonged cell survival—to optimize conditions for their transplantation.
[Tissue Engineering] |
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| The authors provide an overview of iPSC lines that have been derived from patients with specific epilepsy types. They discuss the genetic underpinnings and molecular mechanisms of each epilepsy type.
[Molecular and Cellular Neuroscience] |
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| Researchers focus on stem cell-based in vitro modeling of neurodevelopmental disorders, more specifically, the fundamentals and technical advancements in monolayer neuron and brain organoid cultures.
[Archives of Pharmacal Research] |
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| RenovaCare, Inc. has announced that the US FDA conditionally approved the company’s Investigational Device Exemption application to conduct a clinical trial to evaluate the safety and feasibility of autologous stem cells rendered by its CellMist™ System from donor skin and applied topically with the SkinGun™ spray device for treatment of burn wounds.
[RenovaCare] |
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| Cytovia Therapeutics, Inc. has announced today that it has licensed from ProteoNic BV its 2G UNic™ technology for boosting recombinant protein production, allowing for cost-effective manufacturing at large scale. Under the agreement, Cytovia gains non-exclusive, worldwide commercial rights for application of the technology to the development of a number of its proprietary NK Engager multifunctional antibodies.
[Cytovia Therapeutics (GlobeNewswire Inc.)] |
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| November 2 – November 3
Virtual |
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| | The Stem Cell Unit at the University Medical Center Göttingen – Göttingen, Germany |
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| | University of Miami Health System – Miami, Florida, United States |
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| | Swiss Federal Institute of Technology Zurich (ETH Zurich) – Schwerzenbach, Zurich, Switzerland |
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| | Wayne State University – Detroit, Michigan, United States |
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| | University Medical Centre Groningen (UMCG) – Groningen, Netherlands |
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