ESC & iPSC News Volume 15.31 | Aug 19, 2020







2020-08-19 | ESC 15.31


ESC & iPSC News by STEMCELL Technologies
Vol. 15.31 – 19 August, 2020
TOP STORY

Immune-Evasive Human Islet-Like Organoids Ameliorate Diabetes

Researchers generated human islet-like organoids from iPSCs and showed that non-canonical WNT4 signaling drove the metabolic maturation necessary for robust ex vivo glucose-stimulated insulin secretion.
[Nature]

Abstract


New mTeSR™ Plus hPSC Maintenance Medium
PUBLICATIONSRanked by the impact factor of the journal

Generation
of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State

Human PSCs were subject to directed differentiation through a paraxial mesoderm progenitor state that generated brown adipocytes (BAs) at high efficiency. Molecular analysis identified potential regulatory networks for BA development, giving insight into development along this lineage.
[Cell Stem Cell]

AbstractGraphical Abstract

Naive
Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation

Researchers derived PSCs from distinct mouse strains under naive conditions and showed that lines from distinct genetic backgrounds have divergent differentiation capacity, confirming a major role for genetics in PSC phenotypic variability.
[Cell Stem Cell]

Full ArticleGraphical Abstract

Dynamic
Full-Field Optical Coherence Tomography: 3D Live-Imaging of Retinal Organoids

Investigators present dynamic full-field optical coherence tomography as a technique to noninvasively image living human iPSC-derived retinal organoids.
[Light-Science & Applications]

Full Article

Identifying
Proteins Bound to Native Mitotic ESC Chromosomes Reveals Chromatin Repressors are Important for Compaction

A quantitative proteomic comparison between metaphase-arrested cell lysates and chromosome-sorted samples revealed a cohort of proteins that were significantly enriched on mitotic ESC chromosomes.
[Nature Communications]

Full Article

Vulnerability
of Progeroid Smooth Muscle Cells to Biomechanical Forces Is Mediated by MMP13

Scientists developed a microfluidic chip formed by Hutchinson-Gilford Progeria Syndrome-Smooth muscle cells generated from iPSCs, to study their vulnerability to flow shear stress.
[Nature Communications]

Full Article

Developmental
Excitation-Inhibition Imbalance Underlying Psychoses Revealed by Single-Cell Analyses of Discordant Twins-Derived Cerebral Organoids

Brain organoids derived from iPSCs of patients are a powerful avenue to investigate the pathophysiological processes. Scientists generated iPSC-derived cerebral organoids from monozygotic twins discordant for psychosis.
[Molecular Psychiatry]

Full Article

NLRP7
Plays a Functional Role in Regulating BMP4 Signaling During Differentiation of Patient-Derived Trophoblasts

Investigators established an in vitro model of hydatidiform mole using patient-specific iPSCs derived trophoblasts harboring NLRP7 mutations.
[Cell Death & Disease]

Full Article

Aligned
Nanofiber Scaffolds Improve Functionality of Cardiomyocytes Differentiated from Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells

Researchers focused on using Wnt inhibitors to study the differentiation of human iPSC-cardiac progenitor cells under 2D or 3D culture conditions.
[Scientific Reports]

Full Article

Origin
of the Induced Pluripotent Stem Cells Affects Their Differentiation into Dopaminergic Neurons

During 3D organoid formation, the origin of iPSCs affected the levels of FOXA2 and LMX1A only in the first stages of neural differentiation, whereas in the 2D model, differences were detected at the levels of both early and late neural markers.
[International Journal of Molecular Sciences]

Full Article


Checking your cell quality doesn’t have to be difficult - Genetic screening with the hPSC Genetic Analysis Kit
REVIEWS

Induced
Pluripotent Stem Cells as a Platform to Understand Patient‐Specific Responses to Opioids and Anaesthetics

The authors examine the advantages and limitations of iPSC technology, summarize studies using iPSCs that have contributed to our current understanding of anaesthetics and opioid action on the cardiovascular and central nervous system, and describe how iPSC technology can be used to further develop personalized analgesic and sedative pharmacotherapies.
[British Journal of Pharmacology]

Abstract

Maintenance
of Genome Integrity and Active Homologous Recombination in Embryonic Stem Cells

Scientists review the fundamental links between the stem cell-specific HR process and DNA damage response as well as the different strategies employed by ESCs to maintain genomic integrity.
[Experimental and Molecular Medicine]

Full Article

Understanding
Paraxial Mesoderm Development and Sclerotome Specification for Skeletal Repair

The authors summarize the state-of-the-art understanding of mesoderm development and in vitro modeling of mesoderm development using PSCs. They also discuss future perspectives on the use of PSCs to generate skeletal tissues for basic research and clinical applications.
[Experimental and Molecular Medicine]

Full Article

INDUSTRY AND POLICY NEWS

How
Do You Separate Scientifically Sound Stem Cell Therapies from Scams?

For patients who’ve run out of other options, experimental, unproven therapies like stem cell treatments offer new hope. But how do you sort the scientifically legitimate from the dangerous?
[STAT News]

Editorial

FEATURED EVENT

8th
International Conference on Stem Cell Engineering 2021

July 8 – July 10, 2021
Boston, Massachusetts, United States


> See All Events

JOB OPPORTUNITIES

Tenure-Track Faculty Positions – Stem Cell Biology

Memorial Sloan Kettering Cancer Center – New York City, New York, United States

Postdoctoral
Research Fellow – Retinal Regeneration and Cell Transplantation.

Icahn School of Medicine at Mount Sinai – New York City, New York, United States


Assistant Scientist – Neurological Disease Modeling

University of Miami Health System – Miami, Florida, United States

Junior Research Group Leader Position – Experimental Oncology and Stem Cell Biology

Heidelberg Institute for Stem Cell Technologies and Experimental Medicine – Heidelberg, Baden-Württemberg, Germany

Postdoctoral Researcher – iPSC Technology

The Stem Cell Unit at the University Medical Center Göttingen – Göttingen, Germany

> See All Jobs

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