 | | Vol. 15.33 – 2 September, 2020 |
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| Using genetic lineage tracing, transcriptome, and functional studies, researchers identified mesenchymal populations with different roles during pancreatic development.
[Developmental Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors observed that human PSC-cardiomyocytes (hPSC-CMs) expressed the viral receptor ACE2 and other viral processing factors, and that SARS-CoV-2 readily infected and replicated within hPSC-CMs, resulting in rapid cell death.
[Cold Spring Harbor Perspectives in Biology] |
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| Scientists describe the efficient and accelerated generation of enteric nervous system (ENS) progenitors from human PSCs, revealing that retinoic acid was critical for the acquisition of vagal axial identity and early ENS progenitor specification.
[Stem Cell Reports] |
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| Investigators extended the characterization of iPSC‐microglia and iPSC‐macrophages with the analysis of their transcriptome profile. These cellular models were employed to evaluate neuroimmune toxicity in vitro and to investigate the immune‐modulatory properties of interleukin 13.
[Glia] |
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| Phenotypic amyotrophic lateral sclerosis (ALS) skeletal muscle models were developed from iPSCs derived from healthy individuals and ALS patients harboring mutations in the superoxide dismutase 1 gene.
[Scientific Reports] |
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| Scientists found that stepwise treatment with six signaling pathway inhibitors along with nicotinamide increased retinal pigment epithelial (RPE) differentiation efficiency, enabling the RPE sheet generation at high purity without manual selection.
[Scientific Reports] |
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| Researchers evaluated the use of a human placenta-derived extracellular matrix (ECM) hydrogel, HuGentra®, to support tri-lineage differentiation of human iPSCs.
[International Journal of Stem Cells] |
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| ESCs were differentiated into human intestinal organoids (HIOs) and HIOs from the same batch were transplanted on the same day into either the renal subcapsular space or mesentery. Ten weeks were allowed for engraftment and differentiation, at which time they were harvested and assessed.
[PLoS One] |
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| Researchers previously reported that the silk protein sericin promotes viability, maturation, and pigmentation of human fetal retinal pigment epithelial cells (RPE). They uncovered whether these effects could be seen in adult RPE cell line-19 and iPSC-derived RPE.
[Current Eye Research] |
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| The authors consider the experimental potential of various ESC populations and a number of recently identified in vitro culture systems producing states beyond pluripotency and reminiscent of those observed during pre-implantation development.
[Development] |
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| Scientists review the current knowledge on iPSC models for schizophrenia and autism spectrum disorders with emphasis on the discrimination between them.
[Stem Cells Translational Medicine] |
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| Axol Bioscience specialize in the use of stem cell technology to manufacture disease relevant assay systems for the drug discovery industry. They have announced the appointment of Liam Taylor as CEO. Liam will guide the growth of the company, and will focus on maximizing the potential of the team, and its iPSC technologies, products and services.
[Axol Bioscience Ltd.] |
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| Sep 7 – 11, 2022
Woods Hole, Massachusetts, United States |
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| | University of Saskatchewan – Saskatoon, Saskatchewan, Canada |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | Robert Wood Johnson Medical School at Rutgers – Piscataway, New Jersey, United States |
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| | Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | Columbia University – New York City, New York, United States |
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