 | | Vol. 15.36 – 23 September, 2020 |
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| Scientists investigated the susceptibility of human iPSC-derived monolayer brain cells and region-specific brain organoids to SARS-CoV-2 infection.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors further dissected mechanisms of regulatory factors clustering and transcription activation in mouse ESCs.
[Nature Structural & Molecular Biology] |
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| Investigators examined pluripotent, primary, differentiating, and immortalized human cells, and demonstrated that a class of origins, termed core origins, is shared by different cell types and host ~80% of all DNA replication initiation events in any cell population.
[Nature Communications] |
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| Researchers established a reproducible ex vivo model of lung development using transgene‐free human iPSCs generated from fetuses and infants with Bochdalek congenital diaphragmatic hernia, a polygenic disorder associated with fetal lung compression and pulmonary hypoplasia at birth.
[Stem Cells Translational Medicine] |
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| Scientists suggested that shaking culture activated TGF-β expression and Wnt signaling to promote chondrogenic differentiation in mouse iPSCs in vitro.
[Scientific Reports] |
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| In human cardiomyocytes differentiated from iPSCs, AAV-mediated targeted integration fluorescently labeled Mlc2v protein after differentiation, independently of DNA synthesis, and enabled real-time detection of sarcomere contraction in monolayered beating cardiomyocytes.
[Scientific Reports] |
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| Scientists employed disease modeling in vitro by the use of customizable iPSCs to generate a transient abnormal myelopoiesis model.
[Molecular Therapy-Methods & Clinical Development] |
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| Researchers cloned TCR genes from WT1-specific CTLs regenerated from T-iPSCs, and then established WT1-TCR-iPSCs. They showed that the regenerated cytotoxic T lymphocytes from TCR-iPSCs exerted cytotoxic activity comparable to those from T-iPSCs against WT1 peptide-loaded cell line in in vitro model.
[Molecular Therapy-Methods & Clinical Development] |
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| To understand transcriptomic differences in iPSC-derived monolayer neuronal cultures and 3D brain organoids, investigators differentiated eight human iPSC lines from healthy control subjects to generate cerebral organoids and cortical neuron monolayer cultures from the same set of iPSC lines.
[Stem Cells and Development] |
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| The authors discuss the types of mutations acquired by human PSCs and the mechanisms that lead to their accumulation. Recent work suggests that the underlying mutation rate in PSCs is low, although they also seem to be particularly susceptible to genomic damage.
[Nature Reviews Molecular Cell Biology] |
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| Scientists provide a comprehensive overview on the progression of clinical trials for retinal degeneration treatment using four types of stem/progenitor cell-based transplantation to replace degenerative retinal cells and/or to supplement trophic factors from the aspects of safety, effectiveness and their respective advantages and disadvantages.
[Cell Death & Disease] |
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| Stemson Therapeutics announced a $7.5 million seed financing led by Allergan Aesthetics, an AbbVie Company, and impact investor Fortunis Capital to advance development of Stemson’s iPSC-based technology, which is capable of producing the cell types required to initiate hair follicle growth.
[Stemson Therapeutics (Business Wire, Inc.)] |
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| June 10-11, 2021
London, England, United Kingdom |
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| | Zhejiang University – Zhejiang, China |
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| | The University of Georgia – Athens, Georgia, United States |
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| | Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine – Guangzhou, China or Maine, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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