 | | Vol. 15.37 – 30 September, 2020 |
| |
|
|
| Using electrophysiology and live imaging, the authors identified defects in spontaneous neuronal activity and calcium signaling in both organoid- and 2D-derived cortical neurons.
|
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors report that multiple features of the naive state in human and mouse PSCs could be recapitulated without affecting FGF–MEK signaling or global DNA methylation.
[Nature Cell Biology] |
|
|
|
| Ready-made microvessels promoted a sixfold increase in human iPSC–derived cardiomyocyte (hiPSC-CM) survival and superior functional recovery when compared to hiPSC-CMs transplanted alone or cotransplanted with a suspension of dissociated endothelial cells in infarcted rat hearts.
[Science Translational Medicine] |
|
|
|
| Researchers investigated the role of lipoprotein receptor-related protein 6 (LRP6) in heart repair through regulation of cardiomyocyte proliferation. Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal, juvenile and adult mice.
[Cell Research] |
|
|
|
| The authors compared the editing profile of circularly permuted and domain-inlaid Cas9 base editors, and found that on-target editing is largely maintained following their intradomain insertion, but that structural permutation of the adenine base editors can affect differing RNA off-target events.
[Nature Communications] |
|
|
|
| The generation of a tightly controlled ObLiGaRe doxycycline inducible SpCas9 (ODInCas9) transgene and its use in targeted ObLiGaRe resulted in functional integration into both human and mouse cells culminating in the generation of the ODInCas9 mouse.
[Nature Communications] |
|
|
|
| Scientists used RNA‐seq and computational analysis to prioritize long non-coding RNAs that may regulate commitment of pluripotent cells to a neuronal fate and perturbed their expression prior to neuronal differentiation.
[EMBO Reports] |
|
|
|
| Investigators showed proof of concept of human glial progenitor cells (hGPCs) conversion using fetal cells and also established a renewable and reproducible stem cell-based hGPC system for direct neural conversion in vitro.
[Stem Cell Reports] |
|
|
|
| Scientists showed that chemical inhibition of the methyltransferases EHMT1 and EHMT2 counteracts iPSC formation in an enhanced reprogramming system in the presence of ascorbic acid, an effect that is dependent on EHMT1.
[Stem Cell Reports] |
|
|
|
| Researchers generated BAX/BAK double knockout human-induced pluripotent stem cells (hiPSCs), hiPSC-derived neural progenitor cells, neural rosettes, and cerebral organoids to uncover the effects of BAX and BAK deletion in an in vitro model of early human brain development.
[Cell Death & Disease] |
|
|
|
| The authors showed that 12-O-tetradecanoylphorbol-13-acetate could be applied as a cardiomyogenesis-promoting factor for the differentiation of mouse embryonic stem cells in vitro.
[Scientific Reports] |
|
|
|
| Multisite experiments confirmed that the lower limit of detection was 0.001% under various conditions to which the human iPSC lines and culture medium/substrate were subjected.
[Cytotherapy] |
|
|
|
|
| Cardiovascular cells derived from muscular dystrophy patients’ iPSCs are well suited to mimic dystrophin-associated cardiomyopathy and hold great promise for the development of future fully effective therapies. This article conveys the realities of employing precision disease models of dystrophin-associated cardiomyopathy.
[International Journal of Molecular Sciences] |
|
|
|
|
| Qihan Biotech has announced the expansion of its Scientific Advisory Board to include a total of 12 world-renowned experts in synthetic biology, regenerative medicine, transplantation immunology and cell therapy, as well as the formation of several Scientific Advisory Committees.
[Qihan Biotech (Businesswire, Inc.)] |
|
|
|
|
| July 8 – July 10, 2021
Boston, Massachusetts, United States |
|
|
|
|
|
| | Albert Einstein College of Medicine – New York, New York, United States |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| | University of Miami – Miami, Flordia, United States |
|
|
|
| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
