 | | Vol. 15.38 – 7 October, 2020 |
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| Scientists report that the molecular tweezer CLR01 decreased aggregation and toxicity in induced pluripotent stem cell-derived dopaminergic cultures treated with Parkinson’s disease brain protein extracts.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators propose that RNA cytosine 5-hydroxymethylation by Tets is a mark of transcriptome flexibility, inextricably linked to the balance between pluripotency and lineage commitment.
[Nature Communications] |
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| The authors report that a brain‐enriched long non‐coding RNA, NDIME, is located near the MEF2C locus and is required for normal neural differentiation of mouse ESCs.
[EMBO Reports] |
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| Researchers provided a high-resolution lineage map for an organoid model of embryogenesis, insights into epigenetic determinants of fate specification, and a strategy for lineage mapping of rapid differentiation processes.
[Cell Reports] |
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| In iPSC-derived human astrocytes, increasing expression of PICALM reversed endocytic disruptions. The authors identified a functional interaction between two Alzheimer’s disease genetic risk factors—APOE4 and PICALM—centered on the conserved biological process of endocytosis.
[Cell Reports] |
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| Researchers indicated that hippocampal-neural stem cells (NSCs) senescence caused cellular exhaustion, neurogenesis reduction and cognitive impairment during aging, which can be reversed by ESC-small extracellular vesicles (sEVs).
[Molecular Therapy] |
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| Scientists applied an agent-based modeling approach in order to identify plausible biological rules acting at the meso-scale within stem cell collectives that may explain spontaneous patterning of ESCs.
[Scientific Reports] |
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| 3D cortical spheroids derived from human iPSCs were used to replicate the neurodevelopmental window. Results demonstrated that hyaluronan preferentially surrounds nascent excitatory synapses.
[Scientific Reports] |
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| This study displayed histological and immunohistochemical analyses of a malignant tumor model developed from cancer stem cells converted from human iPSCs in a cancer microenvironment prepared from the conditioned medium of a pancreatic cancer cell line.
[Acta Histochemica] |
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| The author reviews two decades of research aimed at overcoming difficulties in the clinical use of ESCs and iPSCs, including practical issues that limit their use, including their inherent properties of tumorigenicity, immunogenicity, and heterogeneity.
[Cell Stem Cell] |
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| Scientists discuss the most recent production methods, challenges currently faced in organoid and spheroid production, and microfabricated and microfluidic applications for improving spheroid and organoid generation.
[Microsystems & Nanoengineering] |
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| The authors present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma.
[iScience] |
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| Allele Biotechnology and Pharmaceuticals, Inc. has been using mRNA as its core technology for creating cGMP-grade iPSC lines for regenerative medicine and oncology for over a decade. The have recently shown that mRNAs encoding the SARS-CoV-2 antigen proteins could be packaged in iPSCs and delivered in extracellular vesicles, potentially together with the viral proteins these mRNAs encode—a dual mRNA and protein vaccine, all naturally packaged in cells.
[Allele Biotechnology and Pharmaceuticals, Inc. (Businesswire, Inc.)] |
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| January 25 – January 27, 2021
Virtual |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | F. Hoffmann-La Roche AG – Basel, Switzerland |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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