 | | Vol. 15.45 – 2 December, 2020 |
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| Scientists demonstrated orthogonal programming by including oligodendrocyte-inducible human (h)PSCs with unmodified hPSCs to generate cerebral organoids, which expedited in situ myelination.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Children with Fanconi anemia (FA) are a paradigm for extreme squamous cell carcinoma susceptibility caused by germline loss-of-function mutations in FA DNA repair pathway genes. To discover epidermal vulnerabilities, patient-derived PSCs conditional for the FA pathway were differentiated into epidermal stem and progenitor cells and PSC-derived epidermal organotypic rafts.
[Cell Stem Cell] |
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| Using minimal exposure to specification cues, scientists derived stem cells from formative mouse epiblast. Unlike ESCs or epiblast-derived stem cells, formative stem cells responded directly to germ cell induction.
[Cell Stem Cell] |
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| Researchers examined whether X-chromosome dampening extends to human prenatal germ cells given their similarities to naive pluripotent cells. They found that female human primordial germ cells displayed reduced X-linked gene expression before entering meiosis.
[Nature Cell Biology] |
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| Investigators generated 95,308 single-cell transcriptomes and reconstructed a lineage tree of the entire differentiation process from human embryonic stem cells to beta-like cells to study temporally regulated genes during differentiation.
[Nature Metabolism] |
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| Scientists revealed a requirement for HP1γ in faithful establishment of transcription elongation in ESCs, which regulates pluripotency.
[Nucleic Acids Research] |
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| Scientists investigated how the proteins secreted by human PSCs in response to developmental exogenous signals affect the progression from endoderm to the hepatic lineage, including their competence to generate nascent hepatic organoids.
[Cell Reports] |
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| The authors developed a high-throughput screening assay based on retinal pigment epithelium derived from human ESCs to reveal enhancers of photoreceptor outer segment phagocytosis.
[Stem Cell Reports] |
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| Investigators reprogrammed human synovial fluid‐derived mesenchymal stem cells (MSCs) into iPSCs using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation.
[Stem Cells] |
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| Scientists resolved human hematopoietic populations at the earliest hematopoiesis stage by single-cell RNA-seq. They characterized the distinct molecular profiling between early primitive and definitive hematopoiesis in both human embryonic stem cell differentiation and early embryonic development.
[Cell Discovery] |
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| The authors defined the aortic embryologic origin-specific proteome in a validated induced pluripotent stem cell smooth muscle cell model to identify novel protein markers associated with Marfan syndrome aneurysm phenotype.
[Scientific Reports] |
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| In order to evaluate the effect of chemically mimicked hypoxia on human PSCs cell survival, investigators analyzed changes in cell viability and several aspects of apoptosis triggered by CoCl2 and dimethyloxalylglycine.
[Scientific Reports] |
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| Scientists summarize the current knowledge about different human PSC-based diabetes models and how these models improved our current understanding of the pathophysiology of distinct forms of diabetes.
[Cellular and Molecular Life Sciences] |
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| The authors discuss iPSC models of autophagy-associated disorders where the disease is caused due to mutations in autophagy-related genes.
[Stem Cell Reviews and Reports] |
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| Gain Therapeutics, Inc. announced a research collaboration with the University of Maryland School of Medicine (UMSOM), to investigate Gain’s structurally targeted allosteric regulators (STARs) in cellular models of neuronopathic Gaucher disease and Parkinson’s disease. STARs are proprietary small molecules targeting novel allosteric binding sites on enzymes.
[Gain Therapeutics, Inc. (Globe Newswire, Inc.)] |
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| To mark the end of Diabetes Awareness Month, Sonia Sidhu, Member of Parliament for Brampton South, on behalf of the Honourable Patty Hajdu, Minister of Health, announced an investment of $6 million through the CIHR-JDRF Partnership to Defeat Diabetes for two Canadian research teams to accelerate the development of stem cell-based therapies for the treatment of type 1 diabetes.
[Juvenile Diabetes Research Foundation] |
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| July 18 – July 23, 2021
Holderness, New Hampshire, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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| | Stanford University – Stanford, California, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Genentech, Inc. – South San Francisco, California, United States |
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